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The map label for this gene is phoP [H]

Identifier: 84622042

GI number: 84622042

Start: 417298

End: 417981

Strand: Direct

Name: phoP [H]

Synonym: XOO_0385

Alternate gene names: 84622042

Gene position: 417298-417981 (Clockwise)

Preceding gene: 84622041

Following gene: 84622043

Centisome position: 8.45

GC content: 59.94

Gene sequence:

>684_bases
ATGCGTATCCTTTTGGTCGAAGACGAAGCTCCGCTGCGCGAAACCCTTGCGGCGCGTCTGAAGCGTGAAGGTTTTGCGGT
TGACGCTGCACAGGACGGCGAAGAAGGCCTCTACATGGGCCGTGAAGTGCCGTTCGACGTTGGCATCATCGATCTTGGCT
TGCCCAAGATGTCGGGCATGGAGCTGATCAAGGCCCTGCGCGATGAAGGCAAGAAATTTCCGGTGCTGATCCTGACCGCG
CGTTCGAGCTGGCAGGACAAGGTCGAAGGCCTCAAGCAGGGCGCCGACGATTACTTGGTCAAGCCGTTCCATGTCGAAGA
GCTGCTGGCGCGCGTCAACGCCTTGCTGCGACGTGCTGCTGGCTGGAGCAAGCCCACGCTGGAATGCGGTCCGGTTGCGC
TGGATCTGGCAGCACAGACGGTGAGCGTCAACGGCGCCAACGTGGATCTGACCAGCTACGAGTACAAGGTGCTTGAGTAC
TTGATGATGCATGCCGGCGAATTGGTCTCCAAGGCCGACCTCACCGAGCACATCTACCAGCAGGACTTCGACCGCGATTC
GAACGTGCTGGAAGTGTTCATCGGTCGTCTGCGCAAGAAGCTCGATCCCGATGGTGAGCTCAAGCCGATCGAAACCGTCC
GTGGTCGCGGCTACCGCTTCGCCATTCCGCGTACCGAAGGCTGA

Upstream 100 bases:

>100_bases
ACGCGCCACCACGCGACGATAACCGCTGAACGTAGACAGTTCTACGTTCAGTCTTATAAATTCCCCGGCCACTGGCCGAC
AACGTAACTAGGAAGAGTGC

Downstream 100 bases:

>100_bases
GTCCGCGCGTCAACGAACGGGAAGACCACGTGCCGGGCCGCTCCAAGTGGTATAGACGCTGGCGGCCGCGCTCGTTGCAG
GCCCGCCAGCTGCTGGCCGC

Product: two-component system regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGLYMGREVPFDVGIIDLGLPKMSGMELIKALRDEGKKFPVLILTA
RSSWQDKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGPVALDLAAQTVSVNGANVDLTSYEYKVLEY
LMMHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDPDGELKPIETVRGRGYRFAIPRTEG

Sequences:

>Translated_227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGLYMGREVPFDVGIIDLGLPKMSGMELIKALRDEGKKFPVLILTA
RSSWQDKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGPVALDLAAQTVSVNGANVDLTSYEYKVLEY
LMMHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDPDGELKPIETVRGRGYRFAIPRTEG
>Mature_227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGLYMGREVPFDVGIIDLGLPKMSGMELIKALRDEGKKFPVLILTA
RSSWQDKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGPVALDLAAQTVSVNGANVDLTSYEYKVLEY
LMMHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDPDGELKPIETVRGRGYRFAIPRTEG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=42.6008968609865, Blast_Score=189, Evalue=9e-50,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.7321428571429, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=40, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=39.9082568807339, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.322869955157, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=40.7239819004525, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.9140271493213, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.0044052863436, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.2775330396476, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.7433628318584, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.8695652173913, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=30.8370044052863, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=33.8983050847458, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.3261802575107, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=37.962962962963, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=32.6732673267327, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=30.5785123966942, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788905, Length=153, Percent_Identity=31.3725490196078, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25388; Mature: 25388

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGLYMGREVPFDVGIIDLGLPKMSGM
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCCCCCCEEECCCCCCCHH
ELIKALRDEGKKFPVLILTARSSWQDKVEGLKQGADDYLVKPFHVEELLARVNALLRRAA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHC
GWSKPTLECGPVALDLAAQTVSVNGANVDLTSYEYKVLEYLMMHAGELVSKADLTEHIYQ
CCCCCCCCCCCEEEEEHHEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNVLEVFIGRLRKKLDPDGELKPIETVRGRGYRFAIPRTEG
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGLYMGREVPFDVGIIDLGLPKMSGM
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCCCCCCEEECCCCCCCHH
ELIKALRDEGKKFPVLILTARSSWQDKVEGLKQGADDYLVKPFHVEELLARVNALLRRAA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHC
GWSKPTLECGPVALDLAAQTVSVNGANVDLTSYEYKVLEYLMMHAGELVSKADLTEHIYQ
CCCCCCCCCCCEEEEEHHEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNVLEVFIGRLRKKLDPDGELKPIETVRGRGYRFAIPRTEG
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA