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The map label for this gene is phoQ [H]

Identifier: 84622043

GI number: 84622043

Start: 418011

End: 419426

Strand: Direct

Name: phoQ [H]

Synonym: XOO_0386

Alternate gene names: 84622043

Gene position: 418011-419426 (Clockwise)

Preceding gene: 84622042

Following gene: 84622044

Centisome position: 8.46

GC content: 63.84

Gene sequence:

>1416_bases
GTGCCGGGCCGCTCCAAGTGGTATAGACGCTGGCGGCCGCGCTCGTTGCAGGCCCGCCAGCTGCTGGCCGCCAGCCTCAG
TCTGGTGGCCTTCCTGGCGCTGGCGGGTTACGCGCTGGATGTGGCGTTTGCCGACACCGCCGAAAAGAATCTGCGCGAGC
GGCTGAAGAACTACGCTTCCGCGTATGCGGCCAATATCGATTTCGTACGCGACGGCTCGCTGTACATCGGCGGGCAACCG
CCCGACCCGCGTTTCGATGTGCCTGGCGGCGGGCTCTATGTCGAAGTTGTACGTCCCGACGAAAGCTGGACCTCGATGTC
GGCCGAAGGCCCGAATATTCCGCACGGCCGCATGCTGGAGCCGCGCCAGGAAGAGTTCATCGGCCCGCTGGAAATGACCC
AGATCGACGGCAGCCTGGGCCAGCTGTATCGCTACGGCCTGGGCGTGAGTTATGTCGAACGCGAACACGGTGGCGAGATT
CCGTACACCATCTATGTGATGGAAGATGCGCGCTCGATGGGCGCGCAGCTGCGCGTGTTCCGTGGTGCGGTGTGGTTCTA
CCTCGGTAGCGCTGGCGTGGTGTTGCTGGTGTTGCAGGCCTTCATTCTGCAATGGAGCCTGCGTCCGCTGCGGCGGGTCA
TCAACGAGCTGACCAAGGTGCAGCGCGGCGAGATCCAGCGCATGAGCGAGCAGCATCCGCGCGAGCTGGAGCCGCTGACC
GACAGCATCAATGCCTTTATCGAGAGCGAGCGCGACAACCTGGAGCGCCAGCGCAATACGCTGGCCGATCTGGCGCATAG
CCTCAAGACACCCATCGCCGTCTTGCGCACGCAATTGGATAGCGGCGCGTCCGAGCGCGATCTGCATGAAGAAATGGATG
TGCAGCTGCGCCGCATGAACGATCTGGTGTCTTACCAGCTGGCACGCGCCGCTTCCAGCGGGCACAAGTTATTCGCCGCG
CCTTTGCCGATCGAGCCGACCGCCGAAGAAATCGTGCGTGGTCTGGAGAAGGTGTATTCGGTCAAGGGCGTGCTGTGCGA
GTTCGATATTTCCCCCGAAGCGCGCTTTCACGGTGAGCCGGGCGATTTGCAGGAGCTGCTCGGCAATTTGCTGGAAAACG
GCTTCAAGTGGGCGCTTAGCCGCGTGCTGTTGACCGCACAACCGGGACCCACGACCGGTAGCCGTCGTGCCGGGTTGATC
CTGTCGGTGGAAGACGACGGCCCCGGCATCGCGCCGGAAGACGTGGCCAAGATCCTGCAGCGCGGTGTGCGTGGCGATGA
GCGCGTGCAAGGGCACGGTATCGGCATGTCGATCGTGCAGGATCTGATCAAGGCCTACCGCGGCGAGTTGCAGGTGGTGC
GCTCGCAGGAACTGGGCGGCGCCCGCTTCGACGTGACCATGCCGCCGGGATTGTGA

Upstream 100 bases:

>100_bases
GTGAGCTCAAGCCGATCGAAACCGTCCGTGGTCGCGGCTACCGCTTCGCCATTCCGCGTACCGAAGGCTGAGTCCGCGCG
TCAACGAACGGGAAGACCAC

Downstream 100 bases:

>100_bases
CCAGCGGGAGTGGCCCGATAAACACCTGGTCAATGTCCACAGGCCTTCCGACAACCGTTTAACCCCGCATGCGTTGGCTT
GCCCATACTGGGTCGGTACG

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWALSRVLLTAQPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKAYRGELQVVRSQELGGARFDVTMPPGL

Sequences:

>Translated_471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWALSRVLLTAQPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKAYRGELQVVRSQELGGARFDVTMPPGL
>Mature_470_residues
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQPP
DPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIP
YTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLTD
SINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAAP
LPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWALSRVLLTAQPGPTTGSRRAGLIL
SVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKAYRGELQVVRSQELGGARFDVTMPPGL

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=288, Percent_Identity=35.4166666666667, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=28.0120481927711, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=23.5507246376812, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=26.8965517241379, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=23.2727272727273, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=29.3388429752066, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52428; Mature: 52296

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCCEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWALSRVLLTAQPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKAYRGELQVVRSQELGGARFDVTMPPGL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure 
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCCEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWALSRVLLTAQPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKAYRGELQVVRSQELGGARFDVTMPPGL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]