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The map label for this gene is aroE [H]

Identifier: 84622029

GI number: 84622029

Start: 405272

End: 406123

Strand: Direct

Name: aroE [H]

Synonym: XOO_0372

Alternate gene names: 84622029

Gene position: 405272-406123 (Clockwise)

Preceding gene: 84622027

Following gene: 84622030

Centisome position: 8.2

GC content: 67.84

Gene sequence:

>852_bases
ATGCCCGTATCCCGTTATGCCGTGTTCGGTCACCCCGTCGCCCATTCGCTGTCGCCGGCTATCCATGCCGACTTCGGGAA
GCAGACCGGCATTGTGCTGGACTACACCGCCATCGATGCGCCGCCGGAGGACTTCAGTGCCGCGCTGCAACGCTTCGCCG
ATGGAGGCGGCAAGGGTGCGAACGTCACCCTGCCGTTGAAAGAAGCGGCCTGTGCGCTGGCCAGTAGCCTCAGCGATCGC
GCGCGGCTGGCCGGGGCGGTGAACACCCTGGTGCGTCACGAGGGCCAGTGGCAGGGCGAGAACACCGACGGTATTGGCCT
GGTACGTGATCTCACCGATCGTCATGGCCTGGATCTGCGCGGTCGCCGCGTCCTGCTGCTGGGCGCCGGCGGCGCTGCAC
GCGGCGTGGCGCCGGCACTGCTGCAAGCCGGCATTACCGAAATGGTGGTGGTGAACCGCTCGCCCGAGCGCGCCGATGCG
TTGTGCGATACATTGGGCGAACCCGGGCGCGTGGTGTCGCGTTACATCGAAGACCTGCGCGATCTGGGCGACTTCGAGCT
GATCGTCAACGCCACCGCCGCTGGCCGCGACCGCGACGCTGGGGCATTCGCGATGCCGCTGGGGCTGGTCAACAGTCTTA
CCGCTGCGGTCGATCTGAACTATGGCGCCACTGCCATCGCGTTCCTGGCGTGGGCGCGTTCGGCGCAATGCCGGTACGCC
ATCGACGGCTTGGGCATGCTGGTAGAGCAGGCCGCCGAAAGCTTCGCGCTGTGGCATGGCGTGCGCCCAGATACCGACCC
GGTCTACGCCGCGCTGCGCGCGCGCGAGGCCGTGCTGGTCAGTGCCGACTGA

Upstream 100 bases:

>100_bases
GCAGAGTAGACTTGCCGCCAGCGTGAGCAGCGTCCATCGATCGTGCATGCGGTGTTCCTGCCTCAAGTCGCGCACAGTCT
AGTCAACCAGAGAGCGTTTC

Downstream 100 bases:

>100_bases
CGTGAACAGCCCCGATGCCACCGCGATCCTGCTGACCCTGGTCACCAGCCTGCTGTCGCGCGTGCCGATGCTGATTGCCG
TGCTGCTTGGCCTGGTCCTG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIVLDYTAIDAPPEDFSAALQRFADGGGKGANVTLPLKEAACALASSLSDR
ARLAGAVNTLVRHEGQWQGENTDGIGLVRDLTDRHGLDLRGRRVLLLGAGGAARGVAPALLQAGITEMVVVNRSPERADA
LCDTLGEPGRVVSRYIEDLRDLGDFELIVNATAAGRDRDAGAFAMPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD

Sequences:

>Translated_283_residues
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIVLDYTAIDAPPEDFSAALQRFADGGGKGANVTLPLKEAACALASSLSDR
ARLAGAVNTLVRHEGQWQGENTDGIGLVRDLTDRHGLDLRGRRVLLLGAGGAARGVAPALLQAGITEMVVVNRSPERADA
LCDTLGEPGRVVSRYIEDLRDLGDFELIVNATAAGRDRDAGAFAMPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
>Mature_282_residues
PVSRYAVFGHPVAHSLSPAIHADFGKQTGIVLDYTAIDAPPEDFSAALQRFADGGGKGANVTLPLKEAACALASSLSDRA
RLAGAVNTLVRHEGQWQGENTDGIGLVRDLTDRHGLDLRGRRVLLLGAGGAARGVAPALLQAGITEMVVVNRSPERADAL
CDTLGEPGRVVSRYIEDLRDLGDFELIVNATAAGRDRDAGAFAMPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYAI
DGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=44.1176470588235, Blast_Score=202, Evalue=1e-53,
Organism=Escherichia coli, GI1787983, Length=272, Percent_Identity=29.4117647058824, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=279, Percent_Identity=23.6559139784946, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29754; Mature: 29623

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIVLDYTAIDAPPEDFSAALQRFADGGGKGA
CCCCCEEEECCCHHHHCCCHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
NVTLPLKEAACALASSLSDRARLAGAVNTLVRHEGQWQGENTDGIGLVRDLTDRHGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLQAGITEMVVVNRSPERADALCDTLGEPGRVVSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHH
DLGDFELIVNATAAGRDRDAGAFAMPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYA
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCEEH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC
>Mature Secondary Structure 
PVSRYAVFGHPVAHSLSPAIHADFGKQTGIVLDYTAIDAPPEDFSAALQRFADGGGKGA
CCCCEEEECCCHHHHCCCHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
NVTLPLKEAACALASSLSDRARLAGAVNTLVRHEGQWQGENTDGIGLVRDLTDRHGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLQAGITEMVVVNRSPERADALCDTLGEPGRVVSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHH
DLGDFELIVNATAAGRDRDAGAFAMPLGLVNSLTAAVDLNYGATAIAFLAWARSAQCRYA
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCEEH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]