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The map label for this gene is hisI

Identifier: 84489458

GI number: 84489458

Start: 758952

End: 759341

Strand: Direct

Name: hisI

Synonym: Msp_0649

Alternate gene names: 84489458

Gene position: 758952-759341 (Clockwise)

Preceding gene: 84489457

Following gene: 84489459

Centisome position: 42.94

GC content: 29.49

Gene sequence:

>390_bases
ATGATAAAACCAAACTTTAGACATATTATAAATGGTAAAAGATTAGCAACTGCCATAGCCCAAGATTATAAAACAGGTGA
AATATTAATGGTTGCATTTATAGATGAAGAAGCTTTTAATAAAACCATACAAACAAGAAAAGCTCACTACTATAGTACAA
GTAGAAATATGATTTGGTATAAGGGAGAAGAATCAGGACATATTCAAGAGATAAAAGAGGTTCTTCTAGATTGTGATGAA
GATGCAATAATATTTAAAGTAAAACAAGTAGGTGGAGCATGTCATACAGGACATTATTCTTGTTTTTATAAGAAATTATC
AGATGATGGAGAAGTTGTGACTGAATATGAAGATAAGGTATTTGACCCTGAAGATGTATATGAAAAATAA

Upstream 100 bases:

>100_bases
TTGAAGATGAAACAGTAACAATTAAGGATATGGATTCTGGATGTCAGGAAACAATACCACAAAATACTGTTGTATCTGAA
TTACTAAAATAGGGATAAAC

Downstream 100 bases:

>100_bases
GGAGATGTTTTATTGGTTAAAATAGTGCCAGATACTAGTATAATTATAGATCAACAAGTAAGTGTTTTAGTTCAAGATTT
ATATAAAGGTGCAGAAGTAT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MIKPNFRHIINGKRLATAIAQDYKTGEILMVAFIDEEAFNKTIQTRKAHYYSTSRNMIWYKGEESGHIQEIKEVLLDCDE
DAIIFKVKQVGGACHTGHYSCFYKKLSDDGEVVTEYEDKVFDPEDVYEK

Sequences:

>Translated_129_residues
MIKPNFRHIINGKRLATAIAQDYKTGEILMVAFIDEEAFNKTIQTRKAHYYSTSRNMIWYKGEESGHIQEIKEVLLDCDE
DAIIFKVKQVGGACHTGHYSCFYKKLSDDGEVVTEYEDKVFDPEDVYEK
>Mature_129_residues
MIKPNFRHIINGKRLATAIAQDYKTGEILMVAFIDEEAFNKTIQTRKAHYYSTSRNMIWYKGEESGHIQEIKEVLLDCDE
DAIIFKVKQVGGACHTGHYSCFYKKLSDDGEVVTEYEDKVFDPEDVYEK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=34.0909090909091, Blast_Score=77, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_METST (Q2NGK6)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447690.1
- ProteinModelPortal:   Q2NGK6
- SMR:   Q2NGK6
- STRING:   Q2NGK6
- GeneID:   3855438
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0649
- NMPDR:   fig|339860.6.peg.629
- eggNOG:   arNOG12274
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   MSTA339860:MSP_0649-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14950; Mature: 14950

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPNFRHIINGKRLATAIAQDYKTGEILMVAFIDEEAFNKTIQTRKAHYYSTSRNMIWY
CCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHEEECCCCEEEE
KGEESGHIQEIKEVLLDCDEDAIIFKVKQVGGACHTGHYSCFYKKLSDDGEVVTEYEDKV
ECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECHHHCC
FDPEDVYEK
CCHHHHCCC
>Mature Secondary Structure
MIKPNFRHIINGKRLATAIAQDYKTGEILMVAFIDEEAFNKTIQTRKAHYYSTSRNMIWY
CCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHEEECCCCEEEE
KGEESGHIQEIKEVLLDCDEDAIIFKVKQVGGACHTGHYSCFYKKLSDDGEVVTEYEDKV
ECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECHHHCC
FDPEDVYEK
CCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA