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The map label for this gene is uvrB

Identifier: 84489383

GI number: 84489383

Start: 663237

End: 665186

Strand: Direct

Name: uvrB

Synonym: Msp_0573

Alternate gene names: 84489383

Gene position: 663237-665186 (Clockwise)

Preceding gene: 84489381

Following gene: 84489384

Centisome position: 37.53

GC content: 30.97

Gene sequence:

>1950_bases
ATGTCAAAATTCAATTTATATTCTGATTATAAACCATTAGGTGATCAGCCAAAAGCAATAAAATCACTTGTTGAACATTA
TAAAGATGGAATTAAAGAACAAACACTTGAAGGAGTAACAGGTTCTGGAAAAACTTTTACAATGGCAAATGTTATTGAAC
AATTAGACAAACCAACACTTGTAATGTCACATAATAAAACATTAGCAGCTCAATTATATGAGGAATTTAAAGAATTTTTT
CCAGATAATGCAGTGGAATACTTTGTTAGCTACTATGATTACTACCAACCAGAGGCATATGTAGCACAAACTGATACATT
TATTGACAAGGAATCAGCTATTAATGAGGAAATTGATAGATTAAGACACTCTGCCACACAATCATTACTTACAAGAGATG
ATGTAATTGTAGTATCTAGTGTTTCATGTATCTATGGTATAGGTTCACCTGAAGATTATGCACAATTTACACTAACACTA
CAAACACAACAAGAAATATCAAGGGAAGATATTCTTAAAGAATTAGTGAAAATGCAATACTCACGTAATGATATTGAATT
TATAAGGGGACAATTCAGAGTTAGAGGGGACGTTATTGAAATATTTCCAATAAATGCAAATTATGCTCTACGTATTGAAC
TATGGGGTGATGAAATAGATGTTATCTACAAAATAGATGCATTGAAAGGGGATATTATTGAAGAATTACAAAAAGTGATC
ATATTTCCTGCAAAACACTTCGTAATTGCAAAGGAAAAACAAGAAACAGCCATAGCAAACATAAAAAAAGAACTTAAAGA
AAGAGTGGATACATTTAAGGCAACAGGAAAATATGTTGAAGCTCAAAGAATTGAACAAAGAACGAACTTTGATATGGAAA
TGTTACAAGAAATTGGTTACTGTTCTGGAATAGAAAATTATTCCATGCACATGAATGGTCGTAAATGGGGTGAAACACCA
TACTCATTACTAAGATATTTTCCAGATGATTATCTAACAATTATTGATGAATCACATGTAACAGTACCTCAAATACGTGG
AATGTATGAGGGAGATAGGGCAAGAAAAGAAAATCTAATACAGTATGGTTTTAGATTACCTAGTGCAAAGGAAAATAGAC
CACTTCGTTTTGATGAATTTATGAGGGCACAAAATCAAGTATTATATGTTTCAGCAACACCTGCAGCATTTGAATTAGGA
AGAAGTAAAAATAAGGTGGAACAAATTATTAGGCCAACAGGCCTTGTAGATCCAGAGCCTATTGTAAGACCAATAAAAAA
TCAAGTTGATGATTTATTGGGTGAAATAAGAAAATGTGTAGATAATAATCAAAGAGTACTTGTAACATCATTAACTAAGA
AGATGGCAGAGGATTTAACAGATTATTATATTAAGATGAATGTTAAGGCAAGATATTTGCATTCAGAAATTTCAACACTT
GAAAGAACAGAAATTATTGATGAATTACGTCGTGGAGACTTTGATTGTCTAGTTGGAGTAAATCTTCTAAGGGAAGGATT
GGATTTACCAGAAGTTGCACTAGTTGCTATTTTAGATGCTGATAAGGAAGGATTCCTACGTTCTCAAACTTCTCTTATAC
AGACTATTGGTAGAGCTGCACGTAATGTTAATGGTAGAGTAATATTATATGCTGATAATATAACAGATTCTGTAAGAAAT
GCTGTAAATATAACAAAACATAGACGTAAAATACAAATTGCCTATAACAATGATCATAATATTACACCTAGAAGTGTTGT
ACGTAAACTTAAAGATAAAAAGATTGAAGAGAAAGTTGATGATATTCAAGAAATTGATAATATTACAACAGATGAAATTG
ATGAAATAATAAAAGAACTTGAAAAAGAAATGAAACAAGCTGCAAAAGATCTTAACTTTGAAAAGGCTGCAAAACTAAGA
GATAGGATAATGGAATTAAAAGAGGAATAA

Upstream 100 bases:

>100_bases
ATTTATTAATAGATATATTATATATGAAATATATTATACTAACTTTATTATATTGTGTTATGTATAAAAGTTATCAATTA
GTTTTAAGAGAATTATTATT

Downstream 100 bases:

>100_bases
ATAATGGAATCCAAGGAAGAAATAAGAAATAGAGCTATAAAAGATAGAAAAATAATTATAAAAGGAGCAAGAGAACATAA
TCTTCAAAATATTGATGTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSKFNLYSDYKPLGDQPKAIKSLVEHYKDGIKEQTLEGVTGSGKTFTMANVIEQLDKPTLVMSHNKTLAAQLYEEFKEFF
PDNAVEYFVSYYDYYQPEAYVAQTDTFIDKESAINEEIDRLRHSATQSLLTRDDVIVVSSVSCIYGIGSPEDYAQFTLTL
QTQQEISREDILKELVKMQYSRNDIEFIRGQFRVRGDVIEIFPINANYALRIELWGDEIDVIYKIDALKGDIIEELQKVI
IFPAKHFVIAKEKQETAIANIKKELKERVDTFKATGKYVEAQRIEQRTNFDMEMLQEIGYCSGIENYSMHMNGRKWGETP
YSLLRYFPDDYLTIIDESHVTVPQIRGMYEGDRARKENLIQYGFRLPSAKENRPLRFDEFMRAQNQVLYVSATPAAFELG
RSKNKVEQIIRPTGLVDPEPIVRPIKNQVDDLLGEIRKCVDNNQRVLVTSLTKKMAEDLTDYYIKMNVKARYLHSEISTL
ERTEIIDELRRGDFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSQTSLIQTIGRAARNVNGRVILYADNITDSVRN
AVNITKHRRKIQIAYNNDHNITPRSVVRKLKDKKIEEKVDDIQEIDNITTDEIDEIIKELEKEMKQAAKDLNFEKAAKLR
DRIMELKEE

Sequences:

>Translated_649_residues
MSKFNLYSDYKPLGDQPKAIKSLVEHYKDGIKEQTLEGVTGSGKTFTMANVIEQLDKPTLVMSHNKTLAAQLYEEFKEFF
PDNAVEYFVSYYDYYQPEAYVAQTDTFIDKESAINEEIDRLRHSATQSLLTRDDVIVVSSVSCIYGIGSPEDYAQFTLTL
QTQQEISREDILKELVKMQYSRNDIEFIRGQFRVRGDVIEIFPINANYALRIELWGDEIDVIYKIDALKGDIIEELQKVI
IFPAKHFVIAKEKQETAIANIKKELKERVDTFKATGKYVEAQRIEQRTNFDMEMLQEIGYCSGIENYSMHMNGRKWGETP
YSLLRYFPDDYLTIIDESHVTVPQIRGMYEGDRARKENLIQYGFRLPSAKENRPLRFDEFMRAQNQVLYVSATPAAFELG
RSKNKVEQIIRPTGLVDPEPIVRPIKNQVDDLLGEIRKCVDNNQRVLVTSLTKKMAEDLTDYYIKMNVKARYLHSEISTL
ERTEIIDELRRGDFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSQTSLIQTIGRAARNVNGRVILYADNITDSVRN
AVNITKHRRKIQIAYNNDHNITPRSVVRKLKDKKIEEKVDDIQEIDNITTDEIDEIIKELEKEMKQAAKDLNFEKAAKLR
DRIMELKEE
>Mature_648_residues
SKFNLYSDYKPLGDQPKAIKSLVEHYKDGIKEQTLEGVTGSGKTFTMANVIEQLDKPTLVMSHNKTLAAQLYEEFKEFFP
DNAVEYFVSYYDYYQPEAYVAQTDTFIDKESAINEEIDRLRHSATQSLLTRDDVIVVSSVSCIYGIGSPEDYAQFTLTLQ
TQQEISREDILKELVKMQYSRNDIEFIRGQFRVRGDVIEIFPINANYALRIELWGDEIDVIYKIDALKGDIIEELQKVII
FPAKHFVIAKEKQETAIANIKKELKERVDTFKATGKYVEAQRIEQRTNFDMEMLQEIGYCSGIENYSMHMNGRKWGETPY
SLLRYFPDDYLTIIDESHVTVPQIRGMYEGDRARKENLIQYGFRLPSAKENRPLRFDEFMRAQNQVLYVSATPAAFELGR
SKNKVEQIIRPTGLVDPEPIVRPIKNQVDDLLGEIRKCVDNNQRVLVTSLTKKMAEDLTDYYIKMNVKARYLHSEISTLE
RTEIIDELRRGDFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSQTSLIQTIGRAARNVNGRVILYADNITDSVRNA
VNITKHRRKIQIAYNNDHNITPRSVVRKLKDKKIEEKVDDIQEIDNITTDEIDEIIKELEKEMKQAAKDLNFEKAAKLRD
RIMELKEE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=54.4227886056971, Blast_Score=699, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_METST (Q2NGT1)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447615.1
- HSSP:   P56981
- ProteinModelPortal:   Q2NGT1
- STRING:   Q2NGT1
- GeneID:   3854824
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0573
- NMPDR:   fig|339860.6.peg.554
- eggNOG:   arNOG04992
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   MSTA339860:MSP_0573-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75082; Mature: 74951

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFNLYSDYKPLGDQPKAIKSLVEHYKDGIKEQTLEGVTGSGKTFTMANVIEQLDKPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCE
VMSHNKTLAAQLYEEFKEFFPDNAVEYFVSYYDYYQPEAYVAQTDTFIDKESAINEEIDR
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCHHHHCHHHHHHHHHHH
LRHSATQSLLTRDDVIVVSSVSCIYGIGSPEDYAQFTLTLQTQQEISREDILKELVKMQY
HHHHHHHHHHCCCCEEEEECCHHHEECCCCCCCEEEEEEEECHHHCCHHHHHHHHHHHHH
SRNDIEFIRGQFRVRGDVIEIFPINANYALRIELWGDEIDVIYKIDALKGDIIEELQKVI
CCCHHHHHHHHHEEECCEEEEEEECCCEEEEEEEECCCEEEEEEEEHHCCHHHHHHHHHH
IFPAKHFVIAKEKQETAIANIKKELKERVDTFKATGKYVEAQRIEQRTNFDMEMLQEIGY
CCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCHH
CSGIENYSMHMNGRKWGETPYSLLRYFPDDYLTIIDESHVTVPQIRGMYEGDRARKENLI
HCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCHHHHHHHH
QYGFRLPSAKENRPLRFDEFMRAQNQVLYVSATPAAFELGRSKNKVEQIIRPTGLVDPEP
HHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHCCCCCCCCHH
IVRPIKNQVDDLLGEIRKCVDNNQRVLVTSLTKKMAEDLTDYYIKMNVKARYLHSEISTL
HHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHH
ERTEIIDELRRGDFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSQTSLIQTIGRAA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHHH
RNVNGRVILYADNITDSVRNAVNITKHRRKIQIAYNNDHNITPRSVVRKLKDKKIEEKVD
HCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DIQEIDNITTDEIDEIIKELEKEMKQAAKDLNFEKAAKLRDRIMELKEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKFNLYSDYKPLGDQPKAIKSLVEHYKDGIKEQTLEGVTGSGKTFTMANVIEQLDKPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCE
VMSHNKTLAAQLYEEFKEFFPDNAVEYFVSYYDYYQPEAYVAQTDTFIDKESAINEEIDR
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCHHHHCHHHHHHHHHHH
LRHSATQSLLTRDDVIVVSSVSCIYGIGSPEDYAQFTLTLQTQQEISREDILKELVKMQY
HHHHHHHHHHCCCCEEEEECCHHHEECCCCCCCEEEEEEEECHHHCCHHHHHHHHHHHHH
SRNDIEFIRGQFRVRGDVIEIFPINANYALRIELWGDEIDVIYKIDALKGDIIEELQKVI
CCCHHHHHHHHHEEECCEEEEEEECCCEEEEEEEECCCEEEEEEEEHHCCHHHHHHHHHH
IFPAKHFVIAKEKQETAIANIKKELKERVDTFKATGKYVEAQRIEQRTNFDMEMLQEIGY
CCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCHH
CSGIENYSMHMNGRKWGETPYSLLRYFPDDYLTIIDESHVTVPQIRGMYEGDRARKENLI
HCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCHHHHHHHH
QYGFRLPSAKENRPLRFDEFMRAQNQVLYVSATPAAFELGRSKNKVEQIIRPTGLVDPEP
HHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHCCCCCCCCHH
IVRPIKNQVDDLLGEIRKCVDNNQRVLVTSLTKKMAEDLTDYYIKMNVKARYLHSEISTL
HHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHH
ERTEIIDELRRGDFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSQTSLIQTIGRAA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHHH
RNVNGRVILYADNITDSVRNAVNITKHRRKIQIAYNNDHNITPRSVVRKLKDKKIEEKVD
HCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DIQEIDNITTDEIDEIIKELEKEMKQAAKDLNFEKAAKLRDRIMELKEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA