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The map label for this gene is yleA [C]

Identifier: 84489190

GI number: 84489190

Start: 442682

End: 443956

Strand: Direct

Name: yleA [C]

Synonym: Msp_0376

Alternate gene names: 84489190

Gene position: 442682-443956 (Clockwise)

Preceding gene: 84489189

Following gene: 84489191

Centisome position: 25.05

GC content: 29.88

Gene sequence:

>1275_bases
ATGAAAATATATTTAGAAACACATGGATGTACATTTAATCAAGCAGATACTGATATTATGGCTAATATCTTAGCTAAGAA
GTATGATATTGTTTATGATGTAGAAGAAGCTGATGTAATTATACTAAATACATGTTATGTAAAACTTCCTACTGAACAGA
AGATGATTACTAAAATTCGTAAATATAAAACCGAGTTTCCAGATAAGAAATTAATTATTGGGGGATGTATGGTTGAAGTT
GATGATAAGAGACTTGAAAAATTTGCTGGTGATGATTGCTGGATTGGACCACATAAACTTGATAAAGTGGATGAGGTGGT
TGAAAAAGCAATAAATGGTGAAGTAGTACATGAATATGGAAAAACTAGGGCTATTAAAGCTGGTAAGGGTAAAAAAAATT
CTGAAAGTTTGGTTCATATTCTTCAAATTTGTGAAGGATGTAATGGTCAATGTACCTTTTGTTGTACAAGAATAGCTCGT
GGTTTTTTAATAAGTTATCCAATTGATGTTATTGTTGAGGAAGCAAAAGATGCAGTTGAACATGGCTGTAAAGAATTACA
AGTCACTGCTCAGGATACTGCATGTTTTGGTATGGATACTGGTGAATCCTTTGCTGATTTACTAAATAAGTTAGGTGCAA
TTGAGGGTGATTTTCGTATTCGTGTAGGTATGATGAATCCACAAAGTATTAAAAATCAATTACATGAAGTAATAGATGCA
TTTAAAAATAATGATAAGATATTTAACTTTGTACATCTACCAATACAATCAGGTAGTCCTAAGGTATTAAAAGAAATGAA
TAGAAAACATACACTAGATGAATATAAATACATACTTAATGAATTTAGAAAAGAAATTCCTCAAATGTCTCTTGCCACTG
ATATTATAGTTGGTTATCCAACAGAAACTGAAGAAGACTTTAATCAAACACTAGAATTACTTAAAGAAATAAAACCTGAT
ATTGTACATATATCAAAGTATATGCACAGGCCTGGTGCAAAATCAAATCATCTTAAAGAAATTGATCATAATATTATGAA
GAATAGATCACATAGAGTAAATCAAGTAAAAACAGAGGTCATGCTAGAGAAAAATAAAGAATATGAAAATACCATTCAAA
ATGTTTTAATTACATCTAAGGGATCCTCTGGTGGATATGTTGGCTACACTGATTCATATAAAAATGTAATAGTGGATGAA
GCTGAAATTGGTTCATTTATGGATGTAAAAATAATTGAAGGTAAAAGAACATATCTCTTAGCACAAAGAATATAA

Upstream 100 bases:

>100_bases
ATGATAAATCTAAAGTTAAATATGATTTATCTGAGTATGTTATTAAAACAACAATTAAAGAAAAAGATTATAATTAAAAT
TTAATATTTTTTGTGATAAC

Downstream 100 bases:

>100_bases
TATGTATAATTAATTAAAAGAGTAAATAAATAAAAAAATAGAAAAGATTTGATATTATGAATTATATAGTATGTCGAAAT
TGTAAAAGAGTTATTGAGGT

Product: 2-methylthioadenine synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKIYLETHGCTFNQADTDIMANILAKKYDIVYDVEEADVIILNTCYVKLPTEQKMITKIRKYKTEFPDKKLIIGGCMVEV
DDKRLEKFAGDDCWIGPHKLDKVDEVVEKAINGEVVHEYGKTRAIKAGKGKKNSESLVHILQICEGCNGQCTFCCTRIAR
GFLISYPIDVIVEEAKDAVEHGCKELQVTAQDTACFGMDTGESFADLLNKLGAIEGDFRIRVGMMNPQSIKNQLHEVIDA
FKNNDKIFNFVHLPIQSGSPKVLKEMNRKHTLDEYKYILNEFRKEIPQMSLATDIIVGYPTETEEDFNQTLELLKEIKPD
IVHISKYMHRPGAKSNHLKEIDHNIMKNRSHRVNQVKTEVMLEKNKEYENTIQNVLITSKGSSGGYVGYTDSYKNVIVDE
AEIGSFMDVKIIEGKRTYLLAQRI

Sequences:

>Translated_424_residues
MKIYLETHGCTFNQADTDIMANILAKKYDIVYDVEEADVIILNTCYVKLPTEQKMITKIRKYKTEFPDKKLIIGGCMVEV
DDKRLEKFAGDDCWIGPHKLDKVDEVVEKAINGEVVHEYGKTRAIKAGKGKKNSESLVHILQICEGCNGQCTFCCTRIAR
GFLISYPIDVIVEEAKDAVEHGCKELQVTAQDTACFGMDTGESFADLLNKLGAIEGDFRIRVGMMNPQSIKNQLHEVIDA
FKNNDKIFNFVHLPIQSGSPKVLKEMNRKHTLDEYKYILNEFRKEIPQMSLATDIIVGYPTETEEDFNQTLELLKEIKPD
IVHISKYMHRPGAKSNHLKEIDHNIMKNRSHRVNQVKTEVMLEKNKEYENTIQNVLITSKGSSGGYVGYTDSYKNVIVDE
AEIGSFMDVKIIEGKRTYLLAQRI
>Mature_424_residues
MKIYLETHGCTFNQADTDIMANILAKKYDIVYDVEEADVIILNTCYVKLPTEQKMITKIRKYKTEFPDKKLIIGGCMVEV
DDKRLEKFAGDDCWIGPHKLDKVDEVVEKAINGEVVHEYGKTRAIKAGKGKKNSESLVHILQICEGCNGQCTFCCTRIAR
GFLISYPIDVIVEEAKDAVEHGCKELQVTAQDTACFGMDTGESFADLLNKLGAIEGDFRIRVGMMNPQSIKNQLHEVIDA
FKNNDKIFNFVHLPIQSGSPKVLKEMNRKHTLDEYKYILNEFRKEIPQMSLATDIIVGYPTETEEDFNQTLELLKEIKPD
IVHISKYMHRPGAKSNHLKEIDHNIMKNRSHRVNQVKTEVMLEKNKEYENTIQNVLITSKGSSGGYVGYTDSYKNVIVDE
AEIGSFMDVKIIEGKRTYLLAQRI

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=441, Percent_Identity=31.9727891156463, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI28872784, Length=446, Percent_Identity=29.1479820627803, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI28872782, Length=446, Percent_Identity=29.1479820627803, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1786882, Length=436, Percent_Identity=27.5229357798165, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1787057, Length=383, Percent_Identity=29.7650130548303, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71996771, Length=347, Percent_Identity=29.971181556196, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17553146, Length=466, Percent_Identity=25.7510729613734, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19922432, Length=435, Percent_Identity=31.4942528735632, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI21356207, Length=442, Percent_Identity=28.2805429864253, Blast_Score=155, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006466
- InterPro:   IPR007197
- InterPro:   IPR002792 [H]

Pfam domain/function: PF04055 Radical_SAM; PF01938 TRAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 48274; Mature: 48274

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50926 TRAM ; PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYLETHGCTFNQADTDIMANILAKKYDIVYDVEEADVIILNTCYVKLPTEQKMITKIR
CEEEEEECCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEEEEEECCCHHHHHHHHH
KYKTEFPDKKLIIGGCMVEVDDKRLEKFAGDDCWIGPHKLDKVDEVVEKAINGEVVHEYG
HHHHCCCCCEEEEEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCC
KTRAIKAGKGKKNSESLVHILQICEGCNGQCTFCCTRIARGFLISYPIDVIVEEAKDAVE
CCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHH
HGCKELQVTAQDTACFGMDTGESFADLLNKLGAIEGDFRIRVGMMNPQSIKNQLHEVIDA
CCHHHEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
FKNNDKIFNFVHLPIQSGSPKVLKEMNRKHTLDEYKYILNEFRKEIPQMSLATDIIVGYP
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHEEEECC
TETEEDFNQTLELLKEIKPDIVHISKYMHRPGAKSNHLKEIDHNIMKNRSHRVNQVKTEV
CCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
MLEKNKEYENTIQNVLITSKGSSGGYVGYTDSYKNVIVDEAEIGSFMDVKIIEGKRTYLL
HHHCCCHHHHHHHHEEEEECCCCCCEEEECCCCCCEEEEHHHCCCEEEEEEECCCCEEEE
AQRI
EECC
>Mature Secondary Structure
MKIYLETHGCTFNQADTDIMANILAKKYDIVYDVEEADVIILNTCYVKLPTEQKMITKIR
CEEEEEECCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEEEEEECCCHHHHHHHHH
KYKTEFPDKKLIIGGCMVEVDDKRLEKFAGDDCWIGPHKLDKVDEVVEKAINGEVVHEYG
HHHHCCCCCEEEEEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCC
KTRAIKAGKGKKNSESLVHILQICEGCNGQCTFCCTRIARGFLISYPIDVIVEEAKDAVE
CCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHH
HGCKELQVTAQDTACFGMDTGESFADLLNKLGAIEGDFRIRVGMMNPQSIKNQLHEVIDA
CCHHHEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
FKNNDKIFNFVHLPIQSGSPKVLKEMNRKHTLDEYKYILNEFRKEIPQMSLATDIIVGYP
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHEEEECC
TETEEDFNQTLELLKEIKPDIVHISKYMHRPGAKSNHLKEIDHNIMKNRSHRVNQVKTEV
CCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
MLEKNKEYENTIQNVLITSKGSSGGYVGYTDSYKNVIVDEAEIGSFMDVKIIEGKRTYLL
HHHCCCHHHHHHHHEEEEECCCCCCEEEECCCCCCEEEEHHHCCCEEEEEEECCCCEEEE
AQRI
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]