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The map label for this gene is nuoL [H]

Identifier: 83720737

GI number: 83720737

Start: 1213470

End: 1215518

Strand: Direct

Name: nuoL [H]

Synonym: BTH_I1072

Alternate gene names: 83720737

Gene position: 1213470-1215518 (Clockwise)

Preceding gene: 83718586

Following gene: 83719938

Centisome position: 31.86

GC content: 62.91

Gene sequence:

>2049_bases
ATGTCAACGACACTCAATGAAAACCTGCTGCTGGCGATTCCGCTCGCTCCGCTGGCCGGCTCGCTGATCGCGGGGCTGTT
CGGCAATGCGGTGGGGCGCAAGGGCGCACATCGCGTGACGATTCTCGGCGTCGCGGTCTCGTTCATTCTTTCCGCGATGG
TGTTCTTCCAGGTACTGGGCGGCGCGAGCTACAACGCGACGGTCTACGAATGGATGAACGTCGGCTCGCTGAAGCTCGAG
GTGGGCTTCCTCGTCGACACGCTGACCGCGATGATGATGGTCGTCGTCACGTTCGTGTCGCTGATGGTGCACATCTACAC
GATCGGCTACATGTCGGAAGAGGACGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGATGC
TCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTCGTGTCGTACCTGCTGATCGGCTTC
TACTTCACGCGTGAGAGCGCGATCTACGCGAACATGAAGGCGTTCCTCGTGAATCGCGTGGGCGACTTCGGCTTCCTGCT
CGGCATCGGCCTCATCCTGGCGTACGCCGGCTCGATGAACTACGGCGAAGTGTTCGCGAAGCGCGCGGAGCTCGCGGCGC
TGAATTTTCCGGGCACTCAGTGGGGTTTGCTGACCGTCGCTTGCATTTGCCTCTTCATCGGCGCGATGGGTAAGTCCGCA
CAGTTCCCGCTGCACGTGTGGCTGCCCGACTCGATGGAAGGCCCGACGCCGATCTCCGCGCTGATTCACGCGGCGACGAT
GGTGACGGCCGGCATCTTCATGGTCACCCGCATGTCGCCGCTGTTCGAGCTGTCCGACGCCGCGCTGTCGTTCATCACGG
TGATCGGCGCGATCACGGCGCTCTTCATGGGCTTCCTCGGCATTGTCCAGAACGACATCAAGCGCGTCGTCGCGTATTCG
ACGCTGTCGCAGCTCGGCTACATGACGGTCGCGCTCGGCGTGTCCGCGTACCCGGTCGCCGTGTTCCATCTGATGACGCA
CGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCGGGCTCGGTGATCATCGGCATGCACCACGATCAGGACATGCGCAACA
TGGGCGGCCTGCGCAAGTACATGCCGATCACGTGGATCACGTCGCTCGTCGGCTCGCTCGCGCTGATCGGCACGCCGTTC
TTCTCGGGCTTCTACTCGAAGGACTCGATCATCGACGCGGTGAAGCTGTCGCACCTGCCGGGCTCGGGCTTCGCGTACTT
CGCGGTTGTCGCGAGCGTGTTCGTCACGGCGCTGTACTCGTTCCGGATGTACTTCCTCGTGTTCCACGGCGAGGAGCGTT
TCCGCCATCCGAAGGCGTTCGGCAACAACCACGGCGCCGAATCGGCCGCGCATCACGGCCATGACGACGACCACGGCCAC
GGCCATGCGCACGAGCCGCACGAAACGCCTTGGGTCGTCTGGGTGCCGCTCGTGCTGCTTGCGATTCCGTCGGTCATCAT
CGGTGCGATCGCGATCGGCCCGATGCTGTACGGCGATTTCTTCCAGCACGGCGTCGCGTTCGACAAGGTGATCTTCATCG
GCCAGAACCACCCGGCGCTCGCCGAGATGGCGGAGGAATTCCACGGCTGGACGGCGATGGGGCTGCACTCGGTGTCGGGC
CTGCCCGTGTGGCTCGCGCTCGCGGGCGTCGTCGTCGCGTGGTTCCTGTACCTGAAGCGCCCGGATCTGCCGGCTGCGAT
CCGTCGTGCGTTCGGCCCGATCTACACGCTGCTCGACAACAAGTACTACATGGACAAGATCAACGAGGTCGTGTTCGCGA
AGGGCTCGATCGCGATCGGCCGCGGTCTGTGGAAGGAAGGCGACGTCGTGGTGATCGACGGCCTCGTCAACGGCAGCGCG
CGCTTCATCGGCTGGTTCGCCGGCGTGATCCGCTTCCTCCAATCCGGTTACATCTATCACTACGCGTTCGCCATGATCAT
CGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
CAATCGGCCTCGCGATTCTGGTGACTCTGTTCCGCAAGCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGT
TAATTTCAGGCAACGCTGTT

Downstream 100 bases:

>100_bases
GGCGGGGGACGACTAATGCACTCTTTTCCGATTCTCAGTACCGCGATCTGGTTGCCGATCGTGTTCGGCCTCGTCGTGCT
CGCGGTCGGCTCCGACAAGA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 682; Mature: 681

Protein sequence:

>682_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVAVSFILSAMVFFQVLGGASYNATVYEWMNVGSLKLE
VGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELAALNFPGTQWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKAFGNNHGAESAAHHGHDDDHGH
GHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSG
LPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPIYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSA
RFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_682_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVAVSFILSAMVFFQVLGGASYNATVYEWMNVGSLKLE
VGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELAALNFPGTQWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKAFGNNHGAESAAHHGHDDDHGH
GHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSG
LPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPIYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSA
RFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_681_residues
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVAVSFILSAMVFFQVLGGASYNATVYEWMNVGSLKLEV
GFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFY
FTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELAALNFPGTQWGLLTVACICLFIGAMGKSAQ
FPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYST
LSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFF
SGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKAFGNNHGAESAAHHGHDDDHGHG
HAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSGL
PVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPIYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSAR
FIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=396, Percent_Identity=39.6464646464646, Blast_Score=291, Evalue=2e-78,
Organism=Escherichia coli, GI1788614, Length=614, Percent_Identity=38.2736156351792, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1788829, Length=421, Percent_Identity=28.2660332541568, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=30.7471264367816, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788827, Length=462, Percent_Identity=27.7056277056277, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1788613, Length=384, Percent_Identity=24.4791666666667, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693160, Length=318, Percent_Identity=25.1572327044025, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI2367154, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74508; Mature: 74376

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVAVSFILSAMVFFQVLG
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GASYNATVYEWMNVGSLKLEVGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLILAYAGSMNYGEVFAKRAELAALNFPGTQWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKAFGNNHGAESAAHHGHDDDHGH
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCHHHCCCCCCCCCC
GHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCHH
AEMAEEFHGWTAMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPIYTLLDN
HHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
KYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYIYH
CHHHHHHHHHHEECCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
YAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVAVSFILSAMVFFQVLG
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GASYNATVYEWMNVGSLKLEVGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLILAYAGSMNYGEVFAKRAELAALNFPGTQWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKAFGNNHGAESAAHHGHDDDHGH
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCHHHCCCCCCCCCC
GHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCHH
AEMAEEFHGWTAMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPIYTLLDN
HHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
KYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYIYH
CHHHHHHHHHHEECCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
YAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]