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The map label for this gene is nuoM [H]

Identifier: 83719938

GI number: 83719938

Start: 1215534

End: 1217024

Strand: Direct

Name: nuoM [H]

Synonym: BTH_I1073

Alternate gene names: 83719938

Gene position: 1215534-1217024 (Clockwise)

Preceding gene: 83720737

Following gene: 83718846

Centisome position: 31.91

GC content: 63.38

Gene sequence:

>1491_bases
ATGCACTCTTTTCCGATTCTCAGTACCGCGATCTGGTTGCCGATCGTGTTCGGCCTCGTCGTGCTCGCGGTCGGCTCCGA
CAAGAATCCCGGCGCGGCGCGCTGGATCGCGCTGATCGGCTCGCTCGCGGGCCTGGCCGTGACGATTCCGCTGATCACGG
GCTTTGACTCGAGCACCGCCGCGCTGCAGTTCGTCGAGCAAACGACTTGGATCGAACGTTTCAACATCTCGTATCACCTG
GGCGTCGACGGCATCTCGATGTGGTTCGTCGTGTTGACCGCGCTCATCACGGTGATCGTCGTGATCGCCGGCTGGGAGGT
GATCACCGAGAACGTGTCGCAGTATCTCGCCGCGTTCCTGATCCTGTCGGGGATCATGATCGGCGTGTTCTCGGCGGCTG
ACGGCCTGCTGTTCTACGTGTTCTTCGAGGCGACGCTGATCCCGATGTACATCATCATCGGCGTGTGGGGCGGCCCGAAC
CGCGTGTACGCGGCGTTCAAGTTCTTCCTGTACACGCTCGCCGGCTCGCTGCTGATGCTGGTCGCGCTGATCTACCTGTA
CACGCAGACGCACTCGTTCGATCTCGCGACGTGGCAGAACGCGAAGATCGCGATGACGCCGCAGGTGCTGCTCTTCATCG
CGTTCTTCCTCGCGTTCGCGGTGAAGGTGCCGATGTGGCCGGTGCACACCTGGCTGCCGGACGCGCACGTCGAAGCGCCG
ACGGGCGGCTCGGTCGTGCTGGCCGCGATCATGCTGAAGCTCGGTGCGTACGGCTTCCTGCGCTTCTCGCTGCCGATCAC
GCCGGACGCGAGCCACTTCTTCGCGCCCGTCGTGATCGCGCTGTCGCTGACCGCGGTGATCTACATCGGCCTCGTCGCGA
TGGTGCAGGCGGACATGAAGAAGCTCGTCGCCTATTCGTCGATCGCGCACATGGGCTTCGTCACGCTCGGCTTCTTCATC
TTCAACCAGCTCGGCGTCGAGGGCGCGATCGTCCAGATGATCTCGCACGGCTTCGTGTCGGGCGCGATGTTCCTCTGCAT
CGGTGTGCTGTACGACCGCCTGCACTCGCGCCAGATCGCCGATTACGGCGGCGTCGTCAACGTGATGCCGAAGTTCGCCG
CGTTCGCGATGCTGTTCTCGATGGCCAACTGCGGCCTGCCGGGCACGTCGGGCTTCGTCGGTGAGTTCATGGTGATCCTC
GCGGCGGTTCAGTACAACTTCTGGATCGCGTTCGGCGCGGCGTTCACGCTGATTCTCGGCGCGGCGTACACGCTGTGGAT
GTACAAGCGCGTGTACTTCGGCGCGGTGACGAGCGACAAGGTCGCGAAGCTGTCGGACATCAGCCGTCGCGAATTCACGA
TGCTCGCCGTGCTCGCCGCGTTCACGCTGCTGATGGGCCTCTATCCGAAGCCCTTCACCGACGTGATGCACGTTTCCGTG
GAAAACCTCCTCTCCCACGTCGCGCAGTCGAAACTGCCGCTGGCCCAGTAA

Upstream 100 bases:

>100_bases
CGGTTACATCTATCACTACGCGTTCGCCATGATCATCGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCA
AATAAGGCGGGGGACGACTA

Downstream 100 bases:

>100_bases
GCCCGAGCGGAGGATACAAAGATCATGCAAAACGCACCTATGAATGTCCTGTTGCCTGATGCGCTGGTGATGGCCGCCAT
CATCGTCGCCTGGCTGAACG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKNPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQTTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVIALSLTAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQYNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVTSDKVAKLSDISRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ

Sequences:

>Translated_496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKNPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQTTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVIALSLTAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQYNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVTSDKVAKLSDISRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ
>Mature_496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKNPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQTTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVIALSLTAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQYNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVTSDKVAKLSDISRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=363, Percent_Identity=35.2617079889807, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI251831117, Length=409, Percent_Identity=24.9388753056235, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788613, Length=468, Percent_Identity=39.5299145299145, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=24.2957746478873, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788831, Length=316, Percent_Identity=25, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788829, Length=340, Percent_Identity=28.5294117647059, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI145693160, Length=450, Percent_Identity=23.7777777777778, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788614, Length=383, Percent_Identity=27.154046997389, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54053; Mature: 54053

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFPILSTAIWLPIVFGLVVLAVGSDKNPGAARWIALIGSLAGLAVTIPLITGFDSSTA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALQFVEQTTWIERFNISYHLGVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFL
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPNRVYAAFKFFLYTLAGSLLML
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
HHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVIALSLTAVIYIGLVAMVQADMK
CCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVAYSSIAHMGFVTLGFFIFNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVILAAVQYNFWIAFGAAFTLILG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYTLWMYKRVYFGAVTSDKVAKLSDISRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ENLLSHVAQSKLPLAQ
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHSFPILSTAIWLPIVFGLVVLAVGSDKNPGAARWIALIGSLAGLAVTIPLITGFDSSTA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALQFVEQTTWIERFNISYHLGVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFL
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPNRVYAAFKFFLYTLAGSLLML
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
HHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVIALSLTAVIYIGLVAMVQADMK
CCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVAYSSIAHMGFVTLGFFIFNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVILAAVQYNFWIAFGAAFTLILG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYTLWMYKRVYFGAVTSDKVAKLSDISRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ENLLSHVAQSKLPLAQ
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]