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The map label for this gene is lpxC [H]

Identifier: 83718597

GI number: 83718597

Start: 1515855

End: 1516769

Strand: Direct

Name: lpxC [H]

Synonym: BTH_I1342

Alternate gene names: 83718597

Gene position: 1515855-1516769 (Clockwise)

Preceding gene: 83721152

Following gene: 83721386

Centisome position: 39.79

GC content: 72.79

Gene sequence:

>915_bases
ATGAGCGCGCCGGCCGGCTGGCAGGCGCGCGAAGGCACCCTCGCGCGCGAGCTCGCGCTGTCGGGCCACGGGCTGCACAC
CGGGCGGCGCGTGCGCGTGCGGATCGCGCCCGCCGACGGCGGCGCGCATGCGCGCGGCATCGTGTTCAGGCGCGTGTGGG
ACGGGCGCGTGCTCGCGACGCTCGCGGCCGGCCCGGCGCTGCGCCGCGCGCAGCCGCTTTGCACGATGCTGCGCAATGAG
GATGGTGTCGGCGTGCGCACGGTCGAGCATCTGCTCGCGTCGCTGCTCGCGTGCGAGATCGATCACGCCATTGTCGAGCT
CGATGCGGAAGAAGTGCCGATTTTGGACGGCAGCGCGCTGCCGTGGGTCGACGCGCTGCGCGCGTGCGGCCGCGTGGCGC
TGCCGGCGCCGAAGCGCTTCATTCGCGTGCTGAAGCCCGTCGTCGTGACGGACGGCGACGGCGCCGCGCGCCGCGAGATG
CGCGTCGAGCCCGCCGCGCGCTACGAGCTCAGCGTGCGCAATGATCTGAAAGGCTTTGGCGACATGCACTGGGGCGGCGT
GCTCACGCCCGACGTGTTCGCCGCCGAGATCGCGCCGTCGCGCTCATACGGGCGAATCAAATGGGCGATTCCCGCGATCG
TCGCCGGCTACTTGCGCGGCGTGCCGATCCTGCGCGGCGCGCGGCCGTCGTGCACCGCGTCGATCGTCGGCTCGCGTGTC
GTCGGCGGCTTGCGGCAGCCGGACGAGTTCGTTCGCCACCGCGTGCTCGACCTGGTCGGCGATCTCGCGCTCGCCGGCGC
GCCGCTGCTCGGCCGCGTATCGGCGTTCCGGCCGAGCCATGAGATGAACTTCCGGCTGATCGAGGCGCTGCTGTCTACCG
CTGGCGCCTGGGAATGGGCCGAGTTCGTCGCGTAA

Upstream 100 bases:

>100_bases
CGCAGCATGCGCTCGACGGCGATGCGCGCCGGGCGCTGAATGTCGGCGACGGCAAGCCCGCCGACGCCGCGCCGGCCACG
CCGAAAACGCTGGTGACCGC

Downstream 100 bases:

>100_bases
TATGTGAGCTTCATCGACAAAAACAGGCGACTTGTTCAGATGGGACTGGGTGATCACCTGCGCCAGCAACTCGCGGCGAA
AGCACTGAAGCGGCAACTGG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSAPAGWQAREGTLARELALSGHGLHTGRRVRVRIAPADGGAHARGIVFRRVWDGRVLATLAAGPALRRAQPLCTMLRNE
DGVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSALPWVDALRACGRVALPAPKRFIRVLKPVVVTDGDGAARREM
RVEPAARYELSVRNDLKGFGDMHWGGVLTPDVFAAEIAPSRSYGRIKWAIPAIVAGYLRGVPILRGARPSCTASIVGSRV
VGGLRQPDEFVRHRVLDLVGDLALAGAPLLGRVSAFRPSHEMNFRLIEALLSTAGAWEWAEFVA

Sequences:

>Translated_304_residues
MSAPAGWQAREGTLARELALSGHGLHTGRRVRVRIAPADGGAHARGIVFRRVWDGRVLATLAAGPALRRAQPLCTMLRNE
DGVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSALPWVDALRACGRVALPAPKRFIRVLKPVVVTDGDGAARREM
RVEPAARYELSVRNDLKGFGDMHWGGVLTPDVFAAEIAPSRSYGRIKWAIPAIVAGYLRGVPILRGARPSCTASIVGSRV
VGGLRQPDEFVRHRVLDLVGDLALAGAPLLGRVSAFRPSHEMNFRLIEALLSTAGAWEWAEFVA
>Mature_303_residues
SAPAGWQAREGTLARELALSGHGLHTGRRVRVRIAPADGGAHARGIVFRRVWDGRVLATLAAGPALRRAQPLCTMLRNED
GVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSALPWVDALRACGRVALPAPKRFIRVLKPVVVTDGDGAARREMR
VEPAARYELSVRNDLKGFGDMHWGGVLTPDVFAAEIAPSRSYGRIKWAIPAIVAGYLRGVPILRGARPSCTASIVGSRVV
GGLRQPDEFVRHRVLDLVGDLALAGAPLLGRVSAFRPSHEMNFRLIEALLSTAGAWEWAEFVA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=299, Percent_Identity=32.4414715719064, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 32760; Mature: 32629

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPAGWQAREGTLARELALSGHGLHTGRRVRVRIAPADGGAHARGIVFRRVWDGRVLAT
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHEEEEEECCCEEEEH
LAAGPALRRAQPLCTMLRNEDGVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSAL
HHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCC
PWVDALRACGRVALPAPKRFIRVLKPVVVTDGDGAARREMRVEPAARYELSVRNDLKGFG
CHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHCCCCCHHEEEEHHHHHCCCC
DMHWGGVLTPDVFAAEIAPSRSYGRIKWAIPAIVAGYLRGVPILRGARPSCTASIVGSRV
CCCCCCCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
VGGLRQPDEFVRHRVLDLVGDLALAGAPLLGRVSAFRPSHEMNFRLIEALLSTAGAWEWA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHH
EFVA
HHCC
>Mature Secondary Structure 
SAPAGWQAREGTLARELALSGHGLHTGRRVRVRIAPADGGAHARGIVFRRVWDGRVLAT
CCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHEEEEEECCCEEEEH
LAAGPALRRAQPLCTMLRNEDGVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSAL
HHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCC
PWVDALRACGRVALPAPKRFIRVLKPVVVTDGDGAARREMRVEPAARYELSVRNDLKGFG
CHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHCCCCCHHEEEEHHHHHCCCC
DMHWGGVLTPDVFAAEIAPSRSYGRIKWAIPAIVAGYLRGVPILRGARPSCTASIVGSRV
CCCCCCCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
VGGLRQPDEFVRHRVLDLVGDLALAGAPLLGRVSAFRPSHEMNFRLIEALLSTAGAWEWA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHH
EFVA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA