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The map label for this gene is kbl [C]

Identifier: 83721386

GI number: 83721386

Start: 1516809

End: 1518131

Strand: Direct

Name: kbl [C]

Synonym: BTH_I1343

Alternate gene names: 83721386

Gene position: 1516809-1518131 (Clockwise)

Preceding gene: 83718597

Following gene: 83721576

Centisome position: 39.82

GC content: 69.46

Gene sequence:

>1323_bases
ATGGGACTGGGTGATCACCTGCGCCAGCAACTCGCGGCGAAAGCACTGAAGCGGCAACTGGACCGCGTGTCCGACGACGG
CGCCGCGCGTCGCGCGCCGCTTTCCGCCACTCTCCAGGCGACGGGCGATCCGCGCAGCTGGTTCGAGGCGATGCCGCAAT
ACCAGCAGGTCAAGATCATCCGTGAGATGGGCGAGAAGCTGCGCGTCGAATCGCCGTTCTTTCGCGTGCACGAGGGCGTC
GCCGGCGCGACGACGCACATCGGCGGGCGCGAATACCTGAACTACGCGAACTACAACTACCTGGGCCTCGCGGGCGACCC
TGTCGTGTCGGCGCGCGCGAAGGAGGCGATCGATCGCTACGGCACGTCGGCGTCGGCGAGCCGGATGGTCGCGGGCGAGC
GGCCCGTGCAGCGCGAGCTCGAGCGCGGCCTCGCGTCGTTCTACGAGACCGACGACTGCGTCGCGTTCGTGAGCGGCCAC
GCGACGAACGTGACCGTGATCGGCGCGCTGTTCGGCCCGGGCGACCTCGTCGTGCACGACGCGCTCGCGCACAACAGCAT
CGTGCAGGGCGCGCAGTTGAGCGGTGCGAAGCGGCTGAGCTTCGCGCACAACGACTGGCGCGCGCTCGACGCGCTGCTCG
CGCGCGCGCGGCGCGAATACCGGCACGTGCTCGTCGCGATCGAGGGGCTCTACAGCATGGACGGCGATATGCCGGACCTC
GCACGCTTCGTCGAGATCAAGCAGCGCTACGGTGCGTTCCTGATGGTCGACGAAGCGCATTCGCTCGGCGTGCTGGGCAA
GCATGGCAAAGGCATCCGCGAGCACTGCGGCGTGCCGTCCGCCGACGTCGATCTGTGGATGGGAACGCTGAGCAAGGTGC
TCGCCGGGTGCGGCGGCTTCATCGCCGGCTGCCAGCCGCTCATCGACATCCTGCGCCATCTCGCGCCGGGCTTCCTGTAC
AGCGTCGGGCTGTCGCCCGTGCTCGCGGCCGCGTCGCTCGCCGCGCTCGAGCGCATGCAGGCCGAGCCGCAGCGGATCGC
GACGCTGCGCGAGCGCGGGCTGCAGTTCCTCACGCAGGCGCGCGAGGCCGGCCTCAACACGGGCACGAGCGAAGGTTACG
CGGTCGTGCCCGTCATCACCGGCAGCTCGCTGAAGGCCGCGCAATGGGCGAACGCGCTCTTCGACGAAGGCATCAACGTG
CAGCCGATCTTCTATCCGGCCGTCGAGGAGAAGGCCGCGCGGCTGCGCTTTTTCATCTGCTCGACGCACGAACCCGAGCA
GATCGAGCGCACGATCGCGGCGCTCGTGCGGCTCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCTGATCGAGGCGCTGCTGTCTACCGCTGGCGCCTGGGAATGGGCCGAGTTCGTCGCGTAATATGTGAGCTTCATCGACA
AAAACAGGCGACTTGTTCAG

Downstream 100 bases:

>100_bases
TCGCGGCAATGGCGATTCCGCCCGTCGCCAGCGCGCTCCGCGCTTCGAGCGAAGCGGCGCCGCGCCCGTCGCCGTGGCGT
TTTCGCGCGGCCGCCGCGAG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGLGDHLRQQLAAKALKRQLDRVSDDGAARRAPLSATLQATGDPRSWFEAMPQYQQVKIIREMGEKLRVESPFFRVHEGV
AGATTHIGGREYLNYANYNYLGLAGDPVVSARAKEAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGH
ATNVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFAHNDWRALDALLARARREYRHVLVAIEGLYSMDGDMPDL
ARFVEIKQRYGAFLMVDEAHSLGVLGKHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLY
SVGLSPVLAAASLAALERMQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINV
QPIFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR

Sequences:

>Translated_440_residues
MGLGDHLRQQLAAKALKRQLDRVSDDGAARRAPLSATLQATGDPRSWFEAMPQYQQVKIIREMGEKLRVESPFFRVHEGV
AGATTHIGGREYLNYANYNYLGLAGDPVVSARAKEAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGH
ATNVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFAHNDWRALDALLARARREYRHVLVAIEGLYSMDGDMPDL
ARFVEIKQRYGAFLMVDEAHSLGVLGKHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLY
SVGLSPVLAAASLAALERMQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINV
QPIFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR
>Mature_439_residues
GLGDHLRQQLAAKALKRQLDRVSDDGAARRAPLSATLQATGDPRSWFEAMPQYQQVKIIREMGEKLRVESPFFRVHEGVA
GATTHIGGREYLNYANYNYLGLAGDPVVSARAKEAIDRYGTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHA
TNVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFAHNDWRALDALLARARREYRHVLVAIEGLYSMDGDMPDLA
RFVEIKQRYGAFLMVDEAHSLGVLGKHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGFIAGCQPLIDILRHLAPGFLYS
VGLSPVLAAASLAALERMQAEPQRIATLRERGLQFLTQAREAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQIERTIAALVRLAR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=385, Percent_Identity=32.7272727272727, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI7657118, Length=372, Percent_Identity=31.7204301075269, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=32.0916905444126, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=31.0055865921788, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=28.7323943661972, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=28.7323943661972, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=28.7323943661972, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI5454084, Length=286, Percent_Identity=34.965034965035, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=28.4507042253521, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=28.4507042253521, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=35.5932203389831, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=31.1428571428571, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=32.5, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=401, Percent_Identity=29.6758104738155, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=416, Percent_Identity=28.8461538461538, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=416, Percent_Identity=28.8461538461538, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=31.7073170731707, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=31.7073170731707, Blast_Score=152, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=417, Percent_Identity=29.0167865707434, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320438, Length=349, Percent_Identity=30.3724928366762, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=26.4925373134328, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=32.112676056338, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=29.7520661157025, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=28.3667621776504, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653280, Length=299, Percent_Identity=29.4314381270903, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653276, Length=299, Percent_Identity=29.4314381270903, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653278, Length=299, Percent_Identity=29.4314381270903, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47847; Mature: 47716

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGDHLRQQLAAKALKRQLDRVSDDGAARRAPLSATLQATGDPRSWFEAMPQYQQVKII
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEECCCCCHHHHHHCCCHHHHHHH
REMGEKLRVESPFFRVHEGVAGATTHIGGREYLNYANYNYLGLAGDPVVSARAKEAIDRY
HHHHHHHCCCCCHHHHHCCCCCCHHCCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHHC
GTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHD
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCEEEEEEEECCCHHHHHH
ALAHNSIVQGAQLSGAKRLSFAHNDWRALDALLARARREYRHVLVAIEGLYSMDGDMPDL
HHHHHHHHCCCHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ARFVEIKQRYGAFLMVDEAHSLGVLGKHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGF
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
IAGCQPLIDILRHLAPGFLYSVGLSPVLAAASLAALERMQAEPQRIATLRERGLQFLTQA
HHCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
REAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQPIFYPAVEEKAARLRFFIC
HHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEE
STHEPEQIERTIAALVRLAR
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLGDHLRQQLAAKALKRQLDRVSDDGAARRAPLSATLQATGDPRSWFEAMPQYQQVKII
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEECCCCCHHHHHHCCCHHHHHHH
REMGEKLRVESPFFRVHEGVAGATTHIGGREYLNYANYNYLGLAGDPVVSARAKEAIDRY
HHHHHHHCCCCCHHHHHCCCCCCHHCCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHHC
GTSASASRMVAGERPVQRELERGLASFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHD
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCEEEEEEEECCCHHHHHH
ALAHNSIVQGAQLSGAKRLSFAHNDWRALDALLARARREYRHVLVAIEGLYSMDGDMPDL
HHHHHHHHCCCHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ARFVEIKQRYGAFLMVDEAHSLGVLGKHGKGIREHCGVPSADVDLWMGTLSKVLAGCGGF
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
IAGCQPLIDILRHLAPGFLYSVGLSPVLAAASLAALERMQAEPQRIATLRERGLQFLTQA
HHCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
REAGLNTGTSEGYAVVPVITGSSLKAAQWANALFDEGINVQPIFYPAVEEKAARLRFFIC
HHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEE
STHEPEQIERTIAALVRLAR
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA