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The map label for this gene is dxs

Identifier: 83590354

GI number: 83590354

Start: 1555787

End: 1557709

Strand: Reverse

Name: dxs

Synonym: Moth_1511

Alternate gene names: 83590354

Gene position: 1557709-1555787 (Counterclockwise)

Preceding gene: 83590355

Following gene: 83590353

Centisome position: 59.26

GC content: 60.79

Gene sequence:

>1923_bases
ATGAGCCTGCTAGAAAAAATCAACGAACCGGCAGCCATAAAAAAATTTACCCTTGCCGAGCTTGATATACTCGCCAGGGA
AATCCGCCAGGAACTGGTCCAGACGGTCGCCCGCACGGGCGGTCACCTGGCCCCCAACCTTGGGGTTGTGGAGCTGACCC
TGGCCCTGCACAGCGTCTTTGATCTACCCCGGGATAAAATCATCTGGGACGTCGGCCACCAGTGCTACGTTCATAAGATC
CTTACCGGACGGCGCCAGGAAATGACCAGCCTGCGTCAGTTCGGGGGCCTGAGCGGTTTTCCCAAGCGGGCCGAAAGCCC
CTACGACGCCTTTGATACCGGGCATAGCAGCACCTCGATCTCGGCTGCCCTGGGGATGGCCCTGGCCCGGGACTTAAAGG
GAGAAGACTACCAGGTGGTGGCTGTTATCGGCGATGGTGCCCTGACGGGCGGGATGGCTTTCGAAGCCATGAACCATGCC
GGCCACCTGCAGGCCAACTTGATTGTTGTCTTAAATGATAATGAGATGTCTATCGCCCCTCCGGTTGGTGGCCTGGCGGC
CTATCTTTCCCGCCTGCGGACGGACCCCATGTATTCCCGAGGTAAGGAAGAGCTGGAGAATCTTCTCAACCGGCTCCCCC
ATTTAGGTCCCCGGGTGCTCAAGGTAATTGATCGCCTCAAGGACAGCTTTAAATATCTGGTCGTTCCAGGCATGTTTTTC
GAAGAGATTGGTTTTACCTACCTGGGGCCCATTGAAGGTCACAATATTGCCCGGTTAAAAGAGGTCCTCCAGCATGCCCG
GAATACCAGAGGCCCGGTCCTGGTACATGTAATTACCACCAAGGGGAAGGGTTACCAGCCGGCCGAGGACCATCCCGACC
GCTTCCACGGCATAGGCCCCTTTGATCCGGCAACAGGGGAACCCCTGGCCGGAGGAGGGCCGCCGACCTACACCTCTGTT
TTTGGTGCCGAACTGGTGCGCCAGGGGGAAAAGAACAACCGCCTGGTGGCCATAACGGCTGCCATGCCCGATGGCACCGG
CCTGACGCCCTTTGCCCGGCGCTTCCCCAAACGCTTTTTTGATGTCGGCATCGCCGAGCAGCACGCCCTGACCCTGGCCG
CCGGCCTGGCCGCTGCCGGGATGCACCCTGTAGTAGCCATCTATTCTACTTTTTTACAGCGGGCCATTGACCAGGTAATC
CACGATATCGCCTTAATGGAGCTGCCGGTGGTCCTGGCCATTGACCGGGCCGGCCTGGTAGGTGAAGACGGTGAAACCCA
CCAGGGTCTCTTTGATGTGTCCCTGTTGCGTTGTGTTCCCGGCCTGGTCCTCATGGCACCCAAGGATGAACAGGAACTGC
GCCACATGCTGGTAACCGCCCTCCAGTACCAAGGACCGGCGGCGCTGCGCTACCCCCGGGGCGCCGGTATGGGTGTGCCC
CTGACGGGAACGGCCCAGCCTTTGCCCATTGGCAAGGGTGAAGTCCTGCGTCGTGGCCGGGATGTCACCATCCTGGCTCT
AGGCCCCCTGGCGTATGCAGCCCTGGAAGCGGCCGGGGACCTGGCAGCCCGGGGTATCGAAGCCACCGTCATTAATCCCC
GGTTTATTAAGCCCCTGGATGAAGACCTGATCCTCACCTGGGCGGATCGCACCGGCCATCTGGTGACCGTGGAAGAACAC
GTCCTGGCCGGGGGCTTTGGCAGCGCCGTTCTGGAACTCCTGGCACGGAACGGGCGCAAGGGTATCCGGGTGCGGTGCCT
GGGGGTGAAGGACGAGTTTGTCCACCAGGGTAAACCAGCCATTTTACGGGAACACTTAGGCTTGACTCCGGCCGGGATCA
GGGCTGCCGTCCAGGCGCTGCTGGCGGAGACCCCGGTCCTGCACCGGCGGCGCAACCAGACAAAGGGGATTTCCGGTGGC
TAA

Upstream 100 bases:

>100_bases
CCAACGAGGTTGTCTTTTTTGTGGGTCGGGTCTTGTATGCCATCGAAAGGCTAACCGGGTGGCAACCCATACCAAATGGA
CCCAGGAAAGGAAGGCGGCC

Downstream 100 bases:

>100_bases
GGAACGATTGGACCTCCTGCTGGTGAGGCGGGGCCTCTACCCCAGCAGGGAACAGGCCCGGACGGCCATCATGGCCGGCG
AGGTCCTGGTTAACGATGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSLLEKINEPAAIKKFTLAELDILAREIRQELVQTVARTGGHLAPNLGVVELTLALHSVFDLPRDKIIWDVGHQCYVHKI
LTGRRQEMTSLRQFGGLSGFPKRAESPYDAFDTGHSSTSISAALGMALARDLKGEDYQVVAVIGDGALTGGMAFEAMNHA
GHLQANLIVVLNDNEMSIAPPVGGLAAYLSRLRTDPMYSRGKEELENLLNRLPHLGPRVLKVIDRLKDSFKYLVVPGMFF
EEIGFTYLGPIEGHNIARLKEVLQHARNTRGPVLVHVITTKGKGYQPAEDHPDRFHGIGPFDPATGEPLAGGGPPTYTSV
FGAELVRQGEKNNRLVAITAAMPDGTGLTPFARRFPKRFFDVGIAEQHALTLAAGLAAAGMHPVVAIYSTFLQRAIDQVI
HDIALMELPVVLAIDRAGLVGEDGETHQGLFDVSLLRCVPGLVLMAPKDEQELRHMLVTALQYQGPAALRYPRGAGMGVP
LTGTAQPLPIGKGEVLRRGRDVTILALGPLAYAALEAAGDLAARGIEATVINPRFIKPLDEDLILTWADRTGHLVTVEEH
VLAGGFGSAVLELLARNGRKGIRVRCLGVKDEFVHQGKPAILREHLGLTPAGIRAAVQALLAETPVLHRRRNQTKGISGG

Sequences:

>Translated_640_residues
MSLLEKINEPAAIKKFTLAELDILAREIRQELVQTVARTGGHLAPNLGVVELTLALHSVFDLPRDKIIWDVGHQCYVHKI
LTGRRQEMTSLRQFGGLSGFPKRAESPYDAFDTGHSSTSISAALGMALARDLKGEDYQVVAVIGDGALTGGMAFEAMNHA
GHLQANLIVVLNDNEMSIAPPVGGLAAYLSRLRTDPMYSRGKEELENLLNRLPHLGPRVLKVIDRLKDSFKYLVVPGMFF
EEIGFTYLGPIEGHNIARLKEVLQHARNTRGPVLVHVITTKGKGYQPAEDHPDRFHGIGPFDPATGEPLAGGGPPTYTSV
FGAELVRQGEKNNRLVAITAAMPDGTGLTPFARRFPKRFFDVGIAEQHALTLAAGLAAAGMHPVVAIYSTFLQRAIDQVI
HDIALMELPVVLAIDRAGLVGEDGETHQGLFDVSLLRCVPGLVLMAPKDEQELRHMLVTALQYQGPAALRYPRGAGMGVP
LTGTAQPLPIGKGEVLRRGRDVTILALGPLAYAALEAAGDLAARGIEATVINPRFIKPLDEDLILTWADRTGHLVTVEEH
VLAGGFGSAVLELLARNGRKGIRVRCLGVKDEFVHQGKPAILREHLGLTPAGIRAAVQALLAETPVLHRRRNQTKGISGG
>Mature_639_residues
SLLEKINEPAAIKKFTLAELDILAREIRQELVQTVARTGGHLAPNLGVVELTLALHSVFDLPRDKIIWDVGHQCYVHKIL
TGRRQEMTSLRQFGGLSGFPKRAESPYDAFDTGHSSTSISAALGMALARDLKGEDYQVVAVIGDGALTGGMAFEAMNHAG
HLQANLIVVLNDNEMSIAPPVGGLAAYLSRLRTDPMYSRGKEELENLLNRLPHLGPRVLKVIDRLKDSFKYLVVPGMFFE
EIGFTYLGPIEGHNIARLKEVLQHARNTRGPVLVHVITTKGKGYQPAEDHPDRFHGIGPFDPATGEPLAGGGPPTYTSVF
GAELVRQGEKNNRLVAITAAMPDGTGLTPFARRFPKRFFDVGIAEQHALTLAAGLAAAGMHPVVAIYSTFLQRAIDQVIH
DIALMELPVVLAIDRAGLVGEDGETHQGLFDVSLLRCVPGLVLMAPKDEQELRHMLVTALQYQGPAALRYPRGAGMGVPL
TGTAQPLPIGKGEVLRRGRDVTILALGPLAYAALEAAGDLAARGIEATVINPRFIKPLDEDLILTWADRTGHLVTVEEHV
LAGGFGSAVLELLARNGRKGIRVRCLGVKDEFVHQGKPAILREHLGLTPAGIRAAVQALLAETPVLHRRRNQTKGISGG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=562, Percent_Identity=26.8683274021352, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4507521, Length=562, Percent_Identity=26.8683274021352, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI133778974, Length=562, Percent_Identity=25.0889679715303, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI225637459, Length=558, Percent_Identity=24.5519713261649, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI225637463, Length=558, Percent_Identity=24.5519713261649, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI225637461, Length=558, Percent_Identity=24.5519713261649, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI156564403, Length=235, Percent_Identity=29.3617021276596, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI291084858, Length=209, Percent_Identity=28.7081339712919, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI4557353, Length=227, Percent_Identity=25.1101321585903, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI34101272, Length=227, Percent_Identity=25.1101321585903, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=48.8782051282051, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=660, Percent_Identity=25.3030303030303, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538422, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506935, Length=173, Percent_Identity=29.4797687861272, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=230, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551847, Length=678, Percent_Identity=25.5162241887906, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45550715, Length=678, Percent_Identity=25.5162241887906, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645119, Length=560, Percent_Identity=25.7142857142857, Blast_Score=136, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24666278, Length=559, Percent_Identity=26.654740608229, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21358145, Length=234, Percent_Identity=32.4786324786325, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650940, Length=234, Percent_Identity=32.4786324786325, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MOOTA (Q2RIB9)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430363.1
- STRING:   Q2RIB9
- GeneID:   3831976
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1511
- NMPDR:   fig|264732.9.peg.1515
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   GKEELEN
- PhylomeDB:   Q2RIB9
- BioCyc:   MTHE264732:MOTH_1511-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69097; Mature: 68966

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLEKINEPAAIKKFTLAELDILAREIRQELVQTVARTGGHLAPNLGVVELTLALHSVF
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DLPRDKIIWDVGHQCYVHKILTGRRQEMTSLRQFGGLSGFPKRAESPYDAFDTGHSSTSI
HCCCHHEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCHH
SAALGMALARDLKGEDYQVVAVIGDGALTGGMAFEAMNHAGHLQANLIVVLNDNEMSIAP
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCEEECC
PVGGLAAYLSRLRTDPMYSRGKEELENLLNRLPHLGPRVLKVIDRLKDSFKYLVVPGMFF
CCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHH
EEIGFTYLGPIEGHNIARLKEVLQHARNTRGPVLVHVITTKGKGYQPAEDHPDRFHGIGP
HHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHCCCCC
FDPATGEPLAGGGPPTYTSVFGAELVRQGEKNNRLVAITAAMPDGTGLTPFARRFPKRFF
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
DVGIAEQHALTLAAGLAAAGMHPVVAIYSTFLQRAIDQVIHDIALMELPVVLAIDRAGLV
HCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
GEDGETHQGLFDVSLLRCVPGLVLMAPKDEQELRHMLVTALQYQGPAALRYPRGAGMGVP
CCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
LTGTAQPLPIGKGEVLRRGRDVTILALGPLAYAALEAAGDLAARGIEATVINPRFIKPLD
CCCCCCCCCCCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEECCHHCCCCC
EDLILTWADRTGHLVTVEEHVLAGGFGSAVLELLARNGRKGIRVRCLGVKDEFVHQGKPA
CCEEEEEECCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCHH
ILREHLGLTPAGIRAAVQALLAETPVLHRRRNQTKGISGG
HHHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SLLEKINEPAAIKKFTLAELDILAREIRQELVQTVARTGGHLAPNLGVVELTLALHSVF
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DLPRDKIIWDVGHQCYVHKILTGRRQEMTSLRQFGGLSGFPKRAESPYDAFDTGHSSTSI
HCCCHHEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCHH
SAALGMALARDLKGEDYQVVAVIGDGALTGGMAFEAMNHAGHLQANLIVVLNDNEMSIAP
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCEEECC
PVGGLAAYLSRLRTDPMYSRGKEELENLLNRLPHLGPRVLKVIDRLKDSFKYLVVPGMFF
CCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHH
EEIGFTYLGPIEGHNIARLKEVLQHARNTRGPVLVHVITTKGKGYQPAEDHPDRFHGIGP
HHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHCCCCC
FDPATGEPLAGGGPPTYTSVFGAELVRQGEKNNRLVAITAAMPDGTGLTPFARRFPKRFF
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
DVGIAEQHALTLAAGLAAAGMHPVVAIYSTFLQRAIDQVIHDIALMELPVVLAIDRAGLV
HCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
GEDGETHQGLFDVSLLRCVPGLVLMAPKDEQELRHMLVTALQYQGPAALRYPRGAGMGVP
CCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
LTGTAQPLPIGKGEVLRRGRDVTILALGPLAYAALEAAGDLAARGIEATVINPRFIKPLD
CCCCCCCCCCCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEECCHHCCCCC
EDLILTWADRTGHLVTVEEHVLAGGFGSAVLELLARNGRKGIRVRCLGVKDEFVHQGKPA
CCEEEEEECCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCHH
ILREHLGLTPAGIRAAVQALLAETPVLHRRRNQTKGISGG
HHHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA