Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 83593959

GI number: 83593959

Start: 3056801

End: 3057406

Strand: Direct

Name: pdxH

Synonym: Rru_A2627

Alternate gene names: 83593959

Gene position: 3056801-3057406 (Clockwise)

Preceding gene: 83593957

Following gene: 83593960

Centisome position: 70.23

GC content: 67.66

Gene sequence:

>606_bases
ATGAGTTCGCTTGAAGATAGAGACCCTTACGCGCTGTTTGCCGAATGGCTGGAAGAGGCCGGGACGACCGAGCCCAACGA
CCCCAACGCGATGGCCCTGGCGACCTGCACGCCCGAGGGGCGGCCGAGCCTGCGCATGGTGCTGCTCAAAGGCGTGATCG
CCCAGGCTGACGCCGAGGGCGGCTTCATTTTCTATACCAATTTGGAAAGCCGCAAGGGCGGGGAGCTGCTGGCCAATCCC
CATGCCGCCCTGTGCTTCCATTGGAAATCCCTGCGTCGGCAGGTCCGGGTCGAGGGACCGGTGGTCGCCGTCAGCGACGC
CGAGGCCGACGCCTATTTCGCCTCGCGCCACCGCGACAGCCGGATCGGCGCCTGGGCGTCGATGCAGTCGCGCCCGCTCC
AGGGCCGCTTCGAGCTCGAACGCCGCGTCGCCCAGTTCGCCGCCCGCTACGCCGTGGGCGCCGTCCCCCGTCCGCCCCAT
TGGTCGGGCTTCCGCGTGGTGCCCGAGGTTATCGAATTCTGGCACGACCGCCCCTTCCGGCTGCATGACCGGGTGGTGTA
TCGTAGCGAGGGAAGCGGCTGGACCCACAGCCGGCTTTATCCCTAA

Upstream 100 bases:

>100_bases
TTGGCCGATGCTGGCTGAATTGACGAGCCGCGGCGGACCCCGCCGGCGGCGCCGTCGACAAGGCCCTTTTCAAGATCTGG
GATCGGGGACATGATTTGTC

Downstream 100 bases:

>100_bases
GGAACCTCGTATTCCCCAAAAGGTCGGGGTGCGACGGGAAAGGAAAACCCATGGGGACGCAACGATCCGACACCCGCGAC
CAATCGGCGCGGCTGATGCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSSLEDRDPYALFAEWLEEAGTTEPNDPNAMALATCTPEGRPSLRMVLLKGVIAQADAEGGFIFYTNLESRKGGELLANP
HAALCFHWKSLRRQVRVEGPVVAVSDAEADAYFASRHRDSRIGAWASMQSRPLQGRFELERRVAQFAARYAVGAVPRPPH
WSGFRVVPEVIEFWHDRPFRLHDRVVYRSEGSGWTHSRLYP

Sequences:

>Translated_201_residues
MSSLEDRDPYALFAEWLEEAGTTEPNDPNAMALATCTPEGRPSLRMVLLKGVIAQADAEGGFIFYTNLESRKGGELLANP
HAALCFHWKSLRRQVRVEGPVVAVSDAEADAYFASRHRDSRIGAWASMQSRPLQGRFELERRVAQFAARYAVGAVPRPPH
WSGFRVVPEVIEFWHDRPFRLHDRVVYRSEGSGWTHSRLYP
>Mature_200_residues
SSLEDRDPYALFAEWLEEAGTTEPNDPNAMALATCTPEGRPSLRMVLLKGVIAQADAEGGFIFYTNLESRKGGELLANPH
AALCFHWKSLRRQVRVEGPVVAVSDAEADAYFASRHRDSRIGAWASMQSRPLQGRFELERRVAQFAARYAVGAVPRPPHW
SGFRVVPEVIEFWHDRPFRLHDRVVYRSEGSGWTHSRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=188, Percent_Identity=46.2765957446808, Blast_Score=164, Evalue=3e-41,
Organism=Escherichia coli, GI1787926, Length=194, Percent_Identity=43.8144329896907, Blast_Score=157, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17553712, Length=206, Percent_Identity=38.3495145631068, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319509, Length=201, Percent_Identity=41.2935323383085, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45551845, Length=216, Percent_Identity=39.3518518518519, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24644901, Length=216, Percent_Identity=39.3518518518519, Blast_Score=136, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24644903, Length=172, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_RHORT (Q2RR21)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427711.1
- HSSP:   P65682
- ProteinModelPortal:   Q2RR21
- SMR:   Q2RR21
- STRING:   Q2RR21
- GeneID:   3836062
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2627
- NMPDR:   fig|1085.1.peg.278
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q2RR21
- ProtClustDB:   PRK05679
- BioCyc:   RRUB269796:RRU_A2627-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 22737; Mature: 22606

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 45-45 BINDING 48-48 BINDING 50-50 BINDING 72-72 BINDING 112-112 BINDING 116-116 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLEDRDPYALFAEWLEEAGTTEPNDPNAMALATCTPEGRPSLRMVLLKGVIAQADAEG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
GFIFYTNLESRKGGELLANPHAALCFHWKSLRRQVRVEGPVVAVSDAEADAYFASRHRDS
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHCCCC
RIGAWASMQSRPLQGRFELERRVAQFAARYAVGAVPRPPHWSGFRVVPEVIEFWHDRPFR
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
LHDRVVYRSEGSGWTHSRLYP
EECEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SSLEDRDPYALFAEWLEEAGTTEPNDPNAMALATCTPEGRPSLRMVLLKGVIAQADAEG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
GFIFYTNLESRKGGELLANPHAALCFHWKSLRRQVRVEGPVVAVSDAEADAYFASRHRDS
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHCCCC
RIGAWASMQSRPLQGRFELERRVAQFAARYAVGAVPRPPHWSGFRVVPEVIEFWHDRPFR
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
LHDRVVYRSEGSGWTHSRLYP
EECEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA