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The map label for this gene is ispA [C]

Identifier: 83593950

GI number: 83593950

Start: 3046037

End: 3046954

Strand: Direct

Name: ispA [C]

Synonym: Rru_A2618

Alternate gene names: 83593950

Gene position: 3046037-3046954 (Clockwise)

Preceding gene: 83593949

Following gene: 83593951

Centisome position: 69.98

GC content: 66.67

Gene sequence:

>918_bases
GTGGGGGACCTTGGGACCGTGAGTCATCTCAACGAAGTCATGGCCGCCGAAGCGCTGGCCATCAACGATCACCTGTCGCA
ACTGATGCCGGCGACGGACGGCCCCGAGGGGCGGGTCGTCGACGCCATGCGCTACGCCGCCCTTGAGGGCGGCAAGCGTC
TGCGGCCGTTTCTGGTCTTGCAGTCGGCGCAGTTGTTTTCGGTGTCGCGGGCCTGCGCGCTGAATGTCGCCGCCGCCATC
GAAATGATCCACTGCTACTCGCTGATCCACGACGACCTGCCGGCGATGGATAACGATGATCTGCGCCGGGGCCGCCCCAC
CGTCCATCGGCAATACGACGAGCCGACCGCCATCCTGGCCGGCGACGCCCTGTTGACCAAGGCCTTCGAGGTCATCGCCC
TGCCCGGCACCCATTCCGATCCGGCGGTGCGCTGCGACTTGGTCACGGAGCTGGCGATCGCCGCCGGCGCCAAGGGCATG
GTCGGCGGTCAGATGATCGATCTGATGGCCGAACGCGGCCTGATCGACGGCGCGCTCGACGTTCCGGCGATCACCCGCAT
GCACCAGCTCAAGACTGGGCGGCTGATCAGCTTCTCCTCGATCGCCGGGGCGATCCTGGGCAAGGCGCCGCGCTCGCAGC
GTCAGGCCCTGTTCAATTACGCCCATGATCTGGGTCTGGCCTTCCAGATCGCCGACGACCTGCTCGATGTGGAGGGCGAT
ACCGCCACCCTGGGCAAGACCGCCGGCAAGGACGAGGCCTCGGGCAAATCCACCTTCGTTTCCCTGCTTGGCCTCGAGCG
CGCCCGCGATCAGGCCGACATGCTGGCCGAACAGGCCGTCAATCACCTTGACGCCTTCGACGAGAAGGCCGACCTGCTGC
GCGCCGTTGCCCGTTTCGTCGTCGACCGCAAAAGCTGA

Upstream 100 bases:

>100_bases
TGAAGGTCGAGCGCATTTCCCTGGGCCCCGACGGCAGCGTCGGCACCGCCCCCTTCGATGCGACGTGAAAGACCATCGGC
GAGACCGGAGCATTCATGAA

Downstream 100 bases:

>100_bases
AGCCCCCCGGGGGTGTTTCCCCCCGTCAAGGGACGGTTTTCATACGAGGAGAATTCCGCCGTGACATCGAGACCGATAAC
GCCGCTTTTGGACACGATCC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGDLGTVSHLNEVMAAEALAINDHLSQLMPATDGPEGRVVDAMRYAALEGGKRLRPFLVLQSAQLFSVSRACALNVAAAI
EMIHCYSLIHDDLPAMDNDDLRRGRPTVHRQYDEPTAILAGDALLTKAFEVIALPGTHSDPAVRCDLVTELAIAAGAKGM
VGGQMIDLMAERGLIDGALDVPAITRMHQLKTGRLISFSSIAGAILGKAPRSQRQALFNYAHDLGLAFQIADDLLDVEGD
TATLGKTAGKDEASGKSTFVSLLGLERARDQADMLAEQAVNHLDAFDEKADLLRAVARFVVDRKS

Sequences:

>Translated_305_residues
MGDLGTVSHLNEVMAAEALAINDHLSQLMPATDGPEGRVVDAMRYAALEGGKRLRPFLVLQSAQLFSVSRACALNVAAAI
EMIHCYSLIHDDLPAMDNDDLRRGRPTVHRQYDEPTAILAGDALLTKAFEVIALPGTHSDPAVRCDLVTELAIAAGAKGM
VGGQMIDLMAERGLIDGALDVPAITRMHQLKTGRLISFSSIAGAILGKAPRSQRQALFNYAHDLGLAFQIADDLLDVEGD
TATLGKTAGKDEASGKSTFVSLLGLERARDQADMLAEQAVNHLDAFDEKADLLRAVARFVVDRKS
>Mature_304_residues
GDLGTVSHLNEVMAAEALAINDHLSQLMPATDGPEGRVVDAMRYAALEGGKRLRPFLVLQSAQLFSVSRACALNVAAAIE
MIHCYSLIHDDLPAMDNDDLRRGRPTVHRQYDEPTAILAGDALLTKAFEVIALPGTHSDPAVRCDLVTELAIAAGAKGMV
GGQMIDLMAERGLIDGALDVPAITRMHQLKTGRLISFSSIAGAILGKAPRSQRQALFNYAHDLGLAFQIADDLLDVEGDT
ATLGKTAGKDEASGKSTFVSLLGLERARDQADMLAEQAVNHLDAFDEKADLLRAVARFVVDRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786623, Length=292, Percent_Identity=45.8904109589041, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789578, Length=232, Percent_Identity=30.1724137931034, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=202, Percent_Identity=27.2277227722772, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651612, Length=281, Percent_Identity=28.1138790035587, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32624; Mature: 32493

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDLGTVSHLNEVMAAEALAINDHLSQLMPATDGPEGRVVDAMRYAALEGGKRLRPFLVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
QSAQLFSVSRACALNVAAAIEMIHCYSLIHDDLPAMDNDDLRRGRPTVHRQYDEPTAILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHCCCCCCEEEE
GDALLTKAFEVIALPGTHSDPAVRCDLVTELAIAAGAKGMVGGQMIDLMAERGLIDGALD
CHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCC
VPAITRMHQLKTGRLISFSSIAGAILGKAPRSQRQALFNYAHDLGLAFQIADDLLDVEGD
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TATLGKTAGKDEASGKSTFVSLLGLERARDQADMLAEQAVNHLDAFDEKADLLRAVARFV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDRKS
HCCCC
>Mature Secondary Structure 
GDLGTVSHLNEVMAAEALAINDHLSQLMPATDGPEGRVVDAMRYAALEGGKRLRPFLVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
QSAQLFSVSRACALNVAAAIEMIHCYSLIHDDLPAMDNDDLRRGRPTVHRQYDEPTAILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHCCCCCCEEEE
GDALLTKAFEVIALPGTHSDPAVRCDLVTELAIAAGAKGMVGGQMIDLMAERGLIDGALD
CHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCC
VPAITRMHQLKTGRLISFSSIAGAILGKAPRSQRQALFNYAHDLGLAFQIADDLLDVEGD
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TATLGKTAGKDEASGKSTFVSLLGLERARDQADMLAEQAVNHLDAFDEKADLLRAVARFV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDRKS
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]