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The map label for this gene is dxs1 [H]

Identifier: 83593951

GI number: 83593951

Start: 3047015

End: 3048952

Strand: Direct

Name: dxs1 [H]

Synonym: Rru_A2619

Alternate gene names: 83593951

Gene position: 3047015-3048952 (Clockwise)

Preceding gene: 83593950

Following gene: 83593952

Centisome position: 70.0

GC content: 68.73

Gene sequence:

>1938_bases
GTGACATCGAGACCGATAACGCCGCTTTTGGACACGATCCGCGGTCCTTCGGACACACGGGGTCTTTCGGTGGCGCAGCT
GGAGCAGCTGGCGCGCGAAGTGCGGGCGGAAATGATCGACGCGGTCTCGGTGACCGGCGGTCATCTGGGCTCGGGGCTTG
GGGTGGTCGAGCTGACGGTGGCCCTCCATCACGTGTTCGACACCCCCGACGACCGCATCATCTGGGATGTCGGCCATCAG
TGTTATCCCCACAAGATCCTGACCGGGCGGCGCGATCGCATCCGCACCCTGCGCCAGGGCGGCGGGCTGTCGGGCTTCAC
CCTGCGCGAGGAAAGCCCCTATGACCCCTTCGGCGCCGGGCATTCCTCGACCTCGATCTCGGCGGGTCTGGGCATGGCCA
TCGGCTCGGCCCTGGCCGGCGACGCCCGCGACGTGGTGGCGGTGATCGGCGATGGCTCGATGAGCGCGGGCATGGCCTAT
GAGGCGATGAACAACGCCGGGGCGGCCAAATCGCGGCTGATCGTCATCCTCAACGACAACGACATGTCGATCGCCCCGCC
GGTGGGGGCGATGAGCGCCTATCTGTCGCGGCTGCTCAGTTCGAAAAGCTGGCTGTCGATCCGCACCCTGGCCAAGGAGA
TCGTCGCCCGCCTGCCCGACGCCCTGGAGCGCACGGCCAAGCGGGCCGAGGAATACGCCCGCGGCATGGTGACGGGCGGT
GGCACGCTGTTCGAGGAGATGGGCTTTTATTACGTCGGGCCGATCGACGGCCATCGCATGGACCATCTGGTGCCGGTGCT
GCGCAACGTGCGCGAGGCCGGGCGCGATGGTCCGGTGCTGATCCACGTGGTGACGCAAAAGGGCAAGGGCTATGCCCCGG
CCGAGAACGCGCCCGACAAATACCACGGCGTGTCGCGCTTCAACGTGGTGACCGGGGTTCAGGAAAAGGCCAAGCCGCAG
GCGCCGTCCTATACGGCGGTGTTTGGCAAGCAGCTGGTGGCGGCGGCGGCCAAGGACCACCGCATCGTCGCGGTGACGGC
GGCGATGCCCGGCGGCACCGGCCTTGACAAGCTGGCGGCGGCCTATCCGCAGCGCTGCTTCGATGTCGGCATCGCCGAAC
AGCACGCCGTGACCTTCGCCGCCGGTCTGGCCTGCGAGGGGTTGAAGCCCTTCGTCGCCCTCTATTCCAGCTTTTTGCAG
CGCGGCTATGATCAGGTGGTCCACGACGTGGTCTTGCAGAAGCTGCCGGTGCGCTTCGCCATCGACCGCGCCGGGTTCGT
CGGCGCCGACGGGGCGACCCATGGCGGCGTCTTCGACATGGCCTTCCTCGGCTGCCTGCCCAATCTGGTGGTGATGTGCG
CCGCCGACGAGGCCGAGCTGGCGCGCATGGTGGTGACGGCGGCCGGCCATGACAGCGGCCCGATCGCCCTGCGCTATCCG
CGCGGCGAGGGCGTGGGGGTGGAGATCCCCGAGGATCCCCAACCTTTGGCGATCGGCAAGGGCCGCATCGTGCGCGAGGG
CAAGGGCGTGGCCCTGCTGTCGATCGGCACCCGGCTGCAGTCGTGCCTGGAGGCCTGCGAGATCCTGGCGGCGCGCGGCC
TGACGCCGACGGTGGCCGACGCCCGCTTCCTCAAACCCTTCGACGAGGAGCTGGTGGCCGATCTCGCCGCCCGCCACGAG
GTGCTGATCGTCGTCGAGGAAGGCGCGATCGGCGGCTTTTGCTCCCATGTCGCCACCTGGCTGGCCAATCAGGGCCTGCT
CGACGGCGGCCTCAAGCTGCGCGCCCTGCATATCCCCGACCGCTTCTTCGAGCACGACGCGCCCGAGGTCCAATGCGCCA
AGGCCGGCATCGACGCCCAGGCCATCACCACCGCCGTCCTCGACGCCCTCAAGCTTGAAACCAGCGCCACCATCGACGCC
GGCGCCCTGAAGGCGTGA

Upstream 100 bases:

>100_bases
GCGCGCCGTTGCCCGTTTCGTCGTCGACCGCAAAAGCTGAAGCCCCCCGGGGGTGTTTCCCCCCGTCAAGGGACGGTTTT
CATACGAGGAGAATTCCGCC

Downstream 100 bases:

>100_bases
CAGGCGTGAACGACGACACGGCGGCCGATGACCGGCGCCCCCCGGGCGACAAGCGCCCGGGCAAGCTGCGCCTTGACCAG
CTTCTGGTCGATCGCGGGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1 [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAY
EAMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
GTLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQ
APSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAAAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQ
RGYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHE
VLIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDA
GALKA

Sequences:

>Translated_645_residues
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAY
EAMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
GTLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQ
APSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAAAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQ
RGYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHE
VLIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDA
GALKA
>Mature_644_residues
TSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYE
AMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGGG
TLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQA
PSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAAAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQR
GYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYPR
GEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHEV
LIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAG
ALKA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=499, Percent_Identity=22.6452905811623, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4507521, Length=499, Percent_Identity=22.6452905811623, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI156564403, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=48.0707395498392, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17539652, Length=431, Percent_Identity=23.8979118329466, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538422, Length=291, Percent_Identity=26.4604810996564, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551847, Length=677, Percent_Identity=22.7474150664697, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45550715, Length=677, Percent_Identity=22.7474150664697, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24645119, Length=310, Percent_Identity=28.0645161290323, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=28.7878787878788, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68165; Mature: 68034

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTV
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALHHVFDTPDDRIIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
HSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYEAMNNAGAAKSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
CCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEECCC
GTLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDK
CHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHH
YHGVSRFNVVTGVQEKAKPQAPSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAA
HCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
AYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQRGYDQVVHDVVLQKLPVRFA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCEEEEEC
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVAD
CCCCCEEECCCCCCCEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHC
ARFLKPFDEELVADLAARHEVLIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPD
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCH
RFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAGALKA
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTV
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALHHVFDTPDDRIIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
HSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYEAMNNAGAAKSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
CCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEECCC
GTLFEEMGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDK
CHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHH
YHGVSRFNVVTGVQEKAKPQAPSYTAVFGKQLVAAAAKDHRIVAVTAAMPGGTGLDKLAA
HCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
AYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQRGYDQVVHDVVLQKLPVRFA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCEEEEEC
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVAD
CCCCCEEECCCCCCCEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHC
ARFLKPFDEELVADLAARHEVLIVVEEGAIGGFCSHVATWLANQGLLDGGLKLRALHIPD
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCH
RFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAGALKA
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA