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The map label for this gene is envZ [H]

Identifier: 83593561

GI number: 83593561

Start: 2584937

End: 2586343

Strand: Direct

Name: envZ [H]

Synonym: Rru_A2226

Alternate gene names: 83593561

Gene position: 2584937-2586343 (Clockwise)

Preceding gene: 83593560

Following gene: 83593562

Centisome position: 59.39

GC content: 66.6

Gene sequence:

>1407_bases
ATGATCGGTCTTTGGGGGCTTGACCCCGCCCAGCCAGTCCTGGGCCGGATCCGCCGCATCCTGCGCCTGGACCATCCGCT
GCTGCGGCCCTTCGCCCGGGCGATCAAGATGATCTTGCCCAAAAGCCTGCTCGGGCGCTCGCTGCTGATCATCGTCATTC
CGCTGATCCTGCTTCAGGTGATCACCGCCACCATCTTTTTCGATCGCCATTGGGACACCATGAGCCGCCGGCTCAATGCC
GCCGTCGGCTCGGAAATCGGCATGGTGCTTGATTTCATGGCGGCCTATCCCGATCCCGAGGAACGGGAATGGATGTTCGC
CCTCGCCTATGGCCGCCAGCAACTGGCCATGCGCTTCGAGCCGGAGGCGACGCTGCCCGGCACCTCGCCGCTGGCCCAGG
ACGATGATTTCGTCGCCCGCACCCTTTATTCCTCGCTGGCCGAGCATACCGACCTGCCCTATCAGGTCGATGTGATCGAC
GATAAAACCCTGGAGATCCGCATCGCCGCGCCCGATGGCCTGCTGACCGTCGAGGTGCCGCGCAAGCGGCTGTTCAGCGT
CACCACCTATATCTTCATCGGCTGGATGACGGTGTCTTCGGTGATCCTCTTCGCCGTGGCGACCGTTTTCATGCGCAATC
AGGTCCGGCCGATCGGCCGGCTGGCCAGCGCCGCCGACGCCCTGGGCAAGGGCCGCGACGTGCCGAATTTCCGCAGCGAA
GGCGCCCTTGAGGTGCGCCGCGCCGCCCTCGCCTTCACCCGCATGCGCGACCGCATCAACCGCCAGATCGCCCAGCGCAC
CGAGATGCTGGCCGGCGTCAGCCATGATCTGCGCACGCCGCTAACCCGCATGCGCCTGCAGCTCGCGCTGATGGAGGGCG
AGGAGGGAACGGTCGAATTGACCGAGGATATCGCCGAGATGGAACGGATGGTCGAGGGCTATCTGGCCTTCGCCCGCGGC
GAAGGCACCGAGGAGACGGTGGCGACCTGCATCACCGATCTGGTCGACGAGGTGGTCGGCCGCATGCGCCGCAACGGCGC
GCGCATCGATCTGCACACCGAACAGCCGCTGACCGTTCCGCTCAAGCCCAATGCCATGGAACGCTGCCTAGCCAATATCA
TCGGCAACGCCCACCGTTTCGGCCAGCATATCGCCGTGCGCGTCGGCGTGCGCGACGGCCATGTCGAGGTGGTGGTCGAC
GACGACGGCCCGGGCATCCCGCCCGAACGGCGCGAAGACGTGTTCCGCGCCTTCTTCCGCATCGAAAGCTCGCGCAACCC
GCGCACCGGCGGCACCGGCCTGGGGCTGACCATCGCCCGCGACGTCGTCCGCGCCATGGGCGGCGATATCTTCCTGGAAA
ACAGCCCCTTCGGCGGCCTGCGCGCCCGCATCCGCCTGCCGATGTGA

Upstream 100 bases:

>100_bases
TGCAGACGGTGCGCGGACGCGGCTACATGCTTCGTCCGGGCTGACACGCCCCTCGCGGTGAAGGGCGCCTTTCGCGCCTC
GGCAAAACAAGGACGCCGCC

Downstream 100 bases:

>100_bases
GGGGCGGAGGCCCGCACAGCCCTGGGCCGGCAAGGGGCGGCTTGCACGCGATCTCTCAAGGGATCGGCGCCGTCCACCTT
TTAGCCGGGTTTGACCCCTT

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MIGLWGLDPAQPVLGRIRRILRLDHPLLRPFARAIKMILPKSLLGRSLLIIVIPLILLQVITATIFFDRHWDTMSRRLNA
AVGSEIGMVLDFMAAYPDPEEREWMFALAYGRQQLAMRFEPEATLPGTSPLAQDDDFVARTLYSSLAEHTDLPYQVDVID
DKTLEIRIAAPDGLLTVEVPRKRLFSVTTYIFIGWMTVSSVILFAVATVFMRNQVRPIGRLASAADALGKGRDVPNFRSE
GALEVRRAALAFTRMRDRINRQIAQRTEMLAGVSHDLRTPLTRMRLQLALMEGEEGTVELTEDIAEMERMVEGYLAFARG
EGTEETVATCITDLVDEVVGRMRRNGARIDLHTEQPLTVPLKPNAMERCLANIIGNAHRFGQHIAVRVGVRDGHVEVVVD
DDGPGIPPERREDVFRAFFRIESSRNPRTGGTGLGLTIARDVVRAMGGDIFLENSPFGGLRARIRLPM

Sequences:

>Translated_468_residues
MIGLWGLDPAQPVLGRIRRILRLDHPLLRPFARAIKMILPKSLLGRSLLIIVIPLILLQVITATIFFDRHWDTMSRRLNA
AVGSEIGMVLDFMAAYPDPEEREWMFALAYGRQQLAMRFEPEATLPGTSPLAQDDDFVARTLYSSLAEHTDLPYQVDVID
DKTLEIRIAAPDGLLTVEVPRKRLFSVTTYIFIGWMTVSSVILFAVATVFMRNQVRPIGRLASAADALGKGRDVPNFRSE
GALEVRRAALAFTRMRDRINRQIAQRTEMLAGVSHDLRTPLTRMRLQLALMEGEEGTVELTEDIAEMERMVEGYLAFARG
EGTEETVATCITDLVDEVVGRMRRNGARIDLHTEQPLTVPLKPNAMERCLANIIGNAHRFGQHIAVRVGVRDGHVEVVVD
DDGPGIPPERREDVFRAFFRIESSRNPRTGGTGLGLTIARDVVRAMGGDIFLENSPFGGLRARIRLPM
>Mature_468_residues
MIGLWGLDPAQPVLGRIRRILRLDHPLLRPFARAIKMILPKSLLGRSLLIIVIPLILLQVITATIFFDRHWDTMSRRLNA
AVGSEIGMVLDFMAAYPDPEEREWMFALAYGRQQLAMRFEPEATLPGTSPLAQDDDFVARTLYSSLAEHTDLPYQVDVID
DKTLEIRIAAPDGLLTVEVPRKRLFSVTTYIFIGWMTVSSVILFAVATVFMRNQVRPIGRLASAADALGKGRDVPNFRSE
GALEVRRAALAFTRMRDRINRQIAQRTEMLAGVSHDLRTPLTRMRLQLALMEGEEGTVELTEDIAEMERMVEGYLAFARG
EGTEETVATCITDLVDEVVGRMRRNGARIDLHTEQPLTVPLKPNAMERCLANIIGNAHRFGQHIAVRVGVRDGHVEVVVD
DDGPGIPPERREDVFRAFFRIESSRNPRTGGTGLGLTIARDVVRAMGGDIFLENSPFGGLRARIRLPM

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=35.4838709677419, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=34.0740740740741, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=30, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=26.5017667844523, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=27.4834437086093, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=27.0491803278689, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=26.7558528428094, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=29.1525423728814, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=27.0833333333333, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=34.0807174887892, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.9406392694064, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=304, Percent_Identity=25, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=26.431718061674, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=411, Percent_Identity=23.6009732360097, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52369; Mature: 52369

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLWGLDPAQPVLGRIRRILRLDHPLLRPFARAIKMILPKSLLGRSLLIIVIPLILLQV
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
ITATIFFDRHWDTMSRRLNAAVGSEIGMVLDFMAAYPDPEEREWMFALAYGRQQLAMRFE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCHHHHHEEEC
PEATLPGTSPLAQDDDFVARTLYSSLAEHTDLPYQVDVIDDKTLEIRIAAPDGLLTVEVP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCEEEEECC
RKRLFSVTTYIFIGWMTVSSVILFAVATVFMRNQVRPIGRLASAADALGKGRDVPNFRSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
GALEVRRAALAFTRMRDRINRQIAQRTEMLAGVSHDLRTPLTRMRLQLALMEGEEGTVEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHEECCCCCCCHH
TEDIAEMERMVEGYLAFARGEGTEETVATCITDLVDEVVGRMRRNGARIDLHTEQPLTVP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEC
LKPNAMERCLANIIGNAHRFGQHIAVRVGVRDGHVEVVVDDDGPGIPPERREDVFRAFFR
CCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IESSRNPRTGGTGLGLTIARDVVRAMGGDIFLENSPFGGLRARIRLPM
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC
>Mature Secondary Structure
MIGLWGLDPAQPVLGRIRRILRLDHPLLRPFARAIKMILPKSLLGRSLLIIVIPLILLQV
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
ITATIFFDRHWDTMSRRLNAAVGSEIGMVLDFMAAYPDPEEREWMFALAYGRQQLAMRFE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCHHHHHEEEC
PEATLPGTSPLAQDDDFVARTLYSSLAEHTDLPYQVDVIDDKTLEIRIAAPDGLLTVEVP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCEEEEECC
RKRLFSVTTYIFIGWMTVSSVILFAVATVFMRNQVRPIGRLASAADALGKGRDVPNFRSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
GALEVRRAALAFTRMRDRINRQIAQRTEMLAGVSHDLRTPLTRMRLQLALMEGEEGTVEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHEECCCCCCCHH
TEDIAEMERMVEGYLAFARGEGTEETVATCITDLVDEVVGRMRRNGARIDLHTEQPLTVP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEC
LKPNAMERCLANIIGNAHRFGQHIAVRVGVRDGHVEVVVDDDGPGIPPERREDVFRAFFR
CCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IESSRNPRTGGTGLGLTIARDVVRAMGGDIFLENSPFGGLRARIRLPM
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]