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The map label for this gene is uvrC

Identifier: 83593555

GI number: 83593555

Start: 2578520

End: 2580439

Strand: Direct

Name: uvrC

Synonym: Rru_A2220

Alternate gene names: 83593555

Gene position: 2578520-2580439 (Clockwise)

Preceding gene: 83593554

Following gene: 83593556

Centisome position: 59.24

GC content: 65.94

Gene sequence:

>1920_bases
ATGACTGACCTGCCCGTCGACGAGCCCGACCGGGACGACGGCGCCGATCAGCCCGACGCCGGCGCCGACCCCGCCACCCC
ACGCGGGGTCGAGGCGATCCGCGCCGCCTTGCGGACGATGCCATCAAGCCCCGGCGTCTATCGCATGATCGATGGCAAGG
GCGATGTTCTCTATGTGGGCAAGGCGCGCAATCTGAAGCGCCGGGTGATCAACTACACCCAGCCCCATCGCCTGCCGGTG
CGCATCCAACGGATGATCGCCGCCACCCTGACGATGGAGGTGCTGACCACCCATACCGAAGCCGAGGCGCTGCTTCTTGA
ATCCAACCTGATCAAGAAGCTGAAGCCGCGCTACAACATCCTTTTGCGCGACGACAAATCCTTCCCTTATATCGAGATCA
CCTCCGATCACGCCTTTCCTCGCATCGTCAAATTCCGCGGCACCCTGCGCAAAGGGGGGGAATATTTCGGCCCCTTCGCC
TCGGCCGGCGCCGTCACCAGTACGCTCACCGCCTTGCAGAAAACCTTTTTGCTGCGCACCTGCGCCGATAACGTTTTTGC
CAGTCGCAGCCGGCCTTGCCTGCTGTTCCAAATCAAGCGCTGCGCCGCGCCCTGCGTCGATCGGGTGGCGGAGGCGGATT
ACAAGGCCCTGGTCGAAGAGGCCCGCGCCTTCCTCAGCGGCTCAAGCAAGGCGCTCCAGCACGATCTGGCCAAGCGCATG
GACGAGGCGGCCCAGGCCCTGGATTACGAACAGGCGGCGATCTTCCGCGACCGCATCAAGGCGCTGACCAATGTCCAGTC
CCATCAGGATATCAATCTGCCGACCCTGGGCGAGGCCGATGTCATCGCCTGCCATCAGGCCGGCGGCCAGACCTGCGTCC
AGGTCTTCTTTTTCCGTGGCGGCCGCAACAACGGCAACCGCTCGTTCTTTCCCGCCCATGCCGGCGACGAGGGCCTGCCC
GAGGTGCTCGAAGCCTTCCTCGGCCAGTTCTACGCCGGCTTCCCGCCGCCGCGCGAGATCTTGCTGCTGACCGACATTCC
CCACCACGATCTGGTCGAACAGGCGCTTTGCCTGCGCGCCGGCCACCGGGTGCGTCTGGTGGTGCCGCGCCGCGGGTCGC
GGCGCAAGCTGATCGACCACGCGTTGGCCAATGCCCGCGAAGCTTTGGGCCGACGGCTGGCCGAAAGCTCGGCCCAGCGC
ACCTTGCTGGAGGGGACGGCCGTGGCCTTCGGTCTCGACGGGCCGCTCCAGCGGGTCGAGATCTACGACAACAGCCATAT
CTCGGGAACCCACGCGGTGGGCGGCATGGTGGTGGCCGGACCGGAAGGCTTCATGAAGGCCGCCTATCGCAAATTCAACA
TCCGCTCGCCCGATATCACCCCGGGCGACGACTACGCCATGATGCGCGAGGTGATGATCCGGCGCTTCGCCCGCGCCCGT
AAGGAAGACCCCGACCGCGACCGTGGCCAGTGGCCCGATCTGGTGCTGATCGACGGCGGCCTCGGCCAGCTCAACGCCGT
CCGCGAGGCCCTGGCCGAGATCGGCGTCGAGGACGTGCCGCTGGTCGGCGTCGCCAAGGGCCCCGACCGCGATGCCGGAC
GCGAGCGGTTCTTCGTTCCGGGGCGGCCACCCTTCATGCTGCGCCACAACGATCCGGTTTTGTATTTCATCCAGCGCCTG
CGCGACGAGGCCCACCGCTTCGCCATCGGCAGCCATCGCACCCGGCGTTCAAAAGCGATCGGAGTCTCGCCCCTTGATAG
CGTTCCGGGCATCGGCGCCAGCCGCAAGAAAGCCCTTCTCCACCATTTCGGCTCGGCCAAGGCGGTTTCCCAGGCCGGAT
TGACCGATCTGGAGGCGGTGGAGGGGATCAGCGCCGCCCTGGCCAAAAAACTCTATGACCACTTCCACAGCGAGGGATAA

Upstream 100 bases:

>100_bases
TGCCCACAGAAATCGTGGATAGCTTCCGCCTTGACAGGCCACACAGGCACCCTCCCGATTCGGATCGTGCCGCGAAAACG
GCCGAAAGGGCCCTTGGCCA

Downstream 100 bases:

>100_bases
AGTCGCCCTCAATGATCCGAAGGGGTGCGCCTTGCCCCCGCACCCTATCACACCGCCGCGGGGACCAGCCCTTGCTCACT
CTGCCCAACATCCTGACCCT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTDLPVDEPDRDDGADQPDAGADPATPRGVEAIRAALRTMPSSPGVYRMIDGKGDVLYVGKARNLKRRVINYTQPHRLPV
RIQRMIAATLTMEVLTTHTEAEALLLESNLIKKLKPRYNILLRDDKSFPYIEITSDHAFPRIVKFRGTLRKGGEYFGPFA
SAGAVTSTLTALQKTFLLRTCADNVFASRSRPCLLFQIKRCAAPCVDRVAEADYKALVEEARAFLSGSSKALQHDLAKRM
DEAAQALDYEQAAIFRDRIKALTNVQSHQDINLPTLGEADVIACHQAGGQTCVQVFFFRGGRNNGNRSFFPAHAGDEGLP
EVLEAFLGQFYAGFPPPREILLLTDIPHHDLVEQALCLRAGHRVRLVVPRRGSRRKLIDHALANAREALGRRLAESSAQR
TLLEGTAVAFGLDGPLQRVEIYDNSHISGTHAVGGMVVAGPEGFMKAAYRKFNIRSPDITPGDDYAMMREVMIRRFARAR
KEDPDRDRGQWPDLVLIDGGLGQLNAVREALAEIGVEDVPLVGVAKGPDRDAGRERFFVPGRPPFMLRHNDPVLYFIQRL
RDEAHRFAIGSHRTRRSKAIGVSPLDSVPGIGASRKKALLHHFGSAKAVSQAGLTDLEAVEGISAALAKKLYDHFHSEG

Sequences:

>Translated_639_residues
MTDLPVDEPDRDDGADQPDAGADPATPRGVEAIRAALRTMPSSPGVYRMIDGKGDVLYVGKARNLKRRVINYTQPHRLPV
RIQRMIAATLTMEVLTTHTEAEALLLESNLIKKLKPRYNILLRDDKSFPYIEITSDHAFPRIVKFRGTLRKGGEYFGPFA
SAGAVTSTLTALQKTFLLRTCADNVFASRSRPCLLFQIKRCAAPCVDRVAEADYKALVEEARAFLSGSSKALQHDLAKRM
DEAAQALDYEQAAIFRDRIKALTNVQSHQDINLPTLGEADVIACHQAGGQTCVQVFFFRGGRNNGNRSFFPAHAGDEGLP
EVLEAFLGQFYAGFPPPREILLLTDIPHHDLVEQALCLRAGHRVRLVVPRRGSRRKLIDHALANAREALGRRLAESSAQR
TLLEGTAVAFGLDGPLQRVEIYDNSHISGTHAVGGMVVAGPEGFMKAAYRKFNIRSPDITPGDDYAMMREVMIRRFARAR
KEDPDRDRGQWPDLVLIDGGLGQLNAVREALAEIGVEDVPLVGVAKGPDRDAGRERFFVPGRPPFMLRHNDPVLYFIQRL
RDEAHRFAIGSHRTRRSKAIGVSPLDSVPGIGASRKKALLHHFGSAKAVSQAGLTDLEAVEGISAALAKKLYDHFHSEG
>Mature_638_residues
TDLPVDEPDRDDGADQPDAGADPATPRGVEAIRAALRTMPSSPGVYRMIDGKGDVLYVGKARNLKRRVINYTQPHRLPVR
IQRMIAATLTMEVLTTHTEAEALLLESNLIKKLKPRYNILLRDDKSFPYIEITSDHAFPRIVKFRGTLRKGGEYFGPFAS
AGAVTSTLTALQKTFLLRTCADNVFASRSRPCLLFQIKRCAAPCVDRVAEADYKALVEEARAFLSGSSKALQHDLAKRMD
EAAQALDYEQAAIFRDRIKALTNVQSHQDINLPTLGEADVIACHQAGGQTCVQVFFFRGGRNNGNRSFFPAHAGDEGLPE
VLEAFLGQFYAGFPPPREILLLTDIPHHDLVEQALCLRAGHRVRLVVPRRGSRRKLIDHALANAREALGRRLAESSAQRT
LLEGTAVAFGLDGPLQRVEIYDNSHISGTHAVGGMVVAGPEGFMKAAYRKFNIRSPDITPGDDYAMMREVMIRRFARARK
EDPDRDRGQWPDLVLIDGGLGQLNAVREALAEIGVEDVPLVGVAKGPDRDAGRERFFVPGRPPFMLRHNDPVLYFIQRLR
DEAHRFAIGSHRTRRSKAIGVSPLDSVPGIGASRKKALLHHFGSAKAVSQAGLTDLEAVEGISAALAKKLYDHFHSEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=41.3114754098361, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=28.4974093264249, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RHORT (Q2RS75)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427307.1
- ProteinModelPortal:   Q2RS75
- STRING:   Q2RS75
- GeneID:   3835648
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2220
- NMPDR:   fig|1085.1.peg.3697
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2RS75
- ProtClustDB:   PRK00558
- BioCyc:   RRUB269796:RRU_A2220-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70458; Mature: 70327

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLPVDEPDRDDGADQPDAGADPATPRGVEAIRAALRTMPSSPGVYRMIDGKGDVLYVG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEE
KARNLKRRVINYTQPHRLPVRIQRMIAATLTMEVLTTHTEAEALLLESNLIKKLKPRYNI
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEE
LLRDDKSFPYIEITSDHAFPRIVKFRGTLRKGGEYFGPFASAGAVTSTLTALQKTFLLRT
EEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CADNVFASRSRPCLLFQIKRCAAPCVDRVAEADYKALVEEARAFLSGSSKALQHDLAKRM
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DEAAQALDYEQAAIFRDRIKALTNVQSHQDINLPTLGEADVIACHQAGGQTCVQVFFFRG
HHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
GRNNGNRSFFPAHAGDEGLPEVLEAFLGQFYAGFPPPREILLLTDIPHHDLVEQALCLRA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHC
GHRVRLVVPRRGSRRKLIDHALANAREALGRRLAESSAQRTLLEGTAVAFGLDGPLQRVE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEE
IYDNSHISGTHAVGGMVVAGPEGFMKAAYRKFNIRSPDITPGDDYAMMREVMIRRFARAR
EECCCCCCCCHHHCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KEDPDRDRGQWPDLVLIDGGLGQLNAVREALAEIGVEDVPLVGVAKGPDRDAGRERFFVP
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECC
GRPPFMLRHNDPVLYFIQRLRDEAHRFAIGSHRTRRSKAIGVSPLDSVPGIGASRKKALL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHH
HHFGSAKAVSQAGLTDLEAVEGISAALAKKLYDHFHSEG
HHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDLPVDEPDRDDGADQPDAGADPATPRGVEAIRAALRTMPSSPGVYRMIDGKGDVLYVG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEE
KARNLKRRVINYTQPHRLPVRIQRMIAATLTMEVLTTHTEAEALLLESNLIKKLKPRYNI
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEE
LLRDDKSFPYIEITSDHAFPRIVKFRGTLRKGGEYFGPFASAGAVTSTLTALQKTFLLRT
EEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CADNVFASRSRPCLLFQIKRCAAPCVDRVAEADYKALVEEARAFLSGSSKALQHDLAKRM
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DEAAQALDYEQAAIFRDRIKALTNVQSHQDINLPTLGEADVIACHQAGGQTCVQVFFFRG
HHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
GRNNGNRSFFPAHAGDEGLPEVLEAFLGQFYAGFPPPREILLLTDIPHHDLVEQALCLRA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHC
GHRVRLVVPRRGSRRKLIDHALANAREALGRRLAESSAQRTLLEGTAVAFGLDGPLQRVE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEE
IYDNSHISGTHAVGGMVVAGPEGFMKAAYRKFNIRSPDITPGDDYAMMREVMIRRFARAR
EECCCCCCCCHHHCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KEDPDRDRGQWPDLVLIDGGLGQLNAVREALAEIGVEDVPLVGVAKGPDRDAGRERFFVP
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECC
GRPPFMLRHNDPVLYFIQRLRDEAHRFAIGSHRTRRSKAIGVSPLDSVPGIGASRKKALL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHH
HHFGSAKAVSQAGLTDLEAVEGISAALAKKLYDHFHSEG
HHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA