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The map label for this gene is bfmBAA [H]

Identifier: 82751122

GI number: 82751122

Start: 1512971

End: 1513963

Strand: Reverse

Name: bfmBAA [H]

Synonym: SAB1390c

Alternate gene names: 82751122

Gene position: 1513963-1512971 (Counterclockwise)

Preceding gene: 82751123

Following gene: 82751121

Centisome position: 55.2

GC content: 37.97

Gene sequence:

>993_bases
ATGATTGATTATAAATCATTAGGCCTTAGCGAAGAAGACCTAAAAGTAATATATAAATGGATGGATTTAGGTAGAAAAAT
AGATGAAAGACTGTGGTTATTGAACCGTGCAGGTAAAATTCCATTTGTTGTAAGTGGTCAAGGACAAGAAGCAACTCAGA
TTGGGATGGCATATGCATTAGAAGAAGGTGATATTACTGCGCCTTATTATAGAGATCTAGCTTTCGTTACTTATATGGGT
ATATCAGCGTATGATACGTTTTTATCAGCGTTTGGAAAGAAAGACGATGTTAACTCTGGTGGAAAACAAATGCCATCACA
CTTTAGTAGTAGAGCAAAGAATATTTTGTCACAAAGTTCACCGGTAGCAACTCAAATACCCCATGCTGTTGGTGCTGCTT
TAGCTCTAAAAATGGATGGTAAGAAGAAAATTGCAACAGCAACTGTTGGTGAAGGTAGCTCAAACCAAGGTGACTTCCAT
GAAGGTTTAAACTTCGCGGGTGTACACAAACTTCCTTTTGTATGTGTCATTATAAATAATAAATATGCAATTTCAGTACC
TGATTCATTACAATACGCAGCTGAAAAATTATCGGATAGAGCACTTGGCTACGGTATACATGGTGAACAAGTAGATGGTA
ATGATCCATTAGCAATGTATAAAGCGATGAAAGAAGCAAGAGATCGAGCTATTTCTGGTCAAGGTTCAACTTTGATTGAA
GCAGTAACTTCTCGTATGACAGCACATTCATCAGATGATGACGACCAATATCGTACGAAAGAAGAGCGTGAAGCGCTTAA
AAAAGCAGACTGCAACGAAAAGTTCAAAAAAGAGTTGCTTTCAGCTGACATTATCGATGATGCTTGGTTGGCAGAAATAG
AAGCAGAACATAAAGACATTATCAATAAAGCGACAAAGGCTGCTGAAGACGCGCCATATCCAAGTGTCGAAGAAGCCTAT
GCATTTGTGTATGAAGAAGGGAGTCTTAACTAA

Upstream 100 bases:

>100_bases
ACTAACAACACACGCGCATCCTTCCATCTCTGAAGTGTTGATGGAATTAGGATTGAAAGCAGAAAGTAGAGCTATTCACG
TATAAATAGGAGGATTTAAC

Downstream 100 bases:

>100_bases
TGGATAAATTATCTTATTTAGAGGCGATTCGCCAGGCACAAGACTTAGCATTACAACAAAATAAAGATGTATTTATTCTT
GGTGAAGATGTTGGTAAAAA

Product: 2-oxoisovalerate dehydrogenase alpha subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEEREALKKADCNEKFKKELLSADIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN

Sequences:

>Translated_330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEEREALKKADCNEKFKKELLSADIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN
>Mature_330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEEREALKKADCNEKFKKELLSADIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=320, Percent_Identity=35.3125, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI258645172, Length=320, Percent_Identity=35.3125, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4505685, Length=319, Percent_Identity=30.0940438871473, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=30.0940438871473, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI291084744, Length=326, Percent_Identity=29.1411042944785, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4885543, Length=283, Percent_Identity=30.7420494699647, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI291084757, Length=171, Percent_Identity=32.7485380116959, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86563355, Length=316, Percent_Identity=34.4936708860759, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI86563357, Length=316, Percent_Identity=34.4936708860759, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17536047, Length=323, Percent_Identity=30.3405572755418, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=323, Percent_Identity=30.3405572755418, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21355903, Length=328, Percent_Identity=34.7560975609756, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24639748, Length=319, Percent_Identity=27.5862068965517, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639746, Length=280, Percent_Identity=28.9285714285714, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639740, Length=280, Percent_Identity=28.9285714285714, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639744, Length=280, Percent_Identity=28.9285714285714, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571106, Length=280, Percent_Identity=28.9285714285714, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36258; Mature: 36258

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
EEGDITAPYYRDLAFVTYMGISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFHEGLNFAGVHKLPFVCVIINN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEECC
KYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AVTSRMTAHSSDDDDQYRTKEEREALKKADCNEKFKKELLSADIIDDAWLAEIEAEHKDI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
INKATKAAEDAPYPSVEEAYAFVYEEGSLN
HHHHHHHHCCCCCCCHHHHHEEEECCCCCC
>Mature Secondary Structure
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
EEGDITAPYYRDLAFVTYMGISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFHEGLNFAGVHKLPFVCVIINN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEECC
KYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AVTSRMTAHSSDDDDQYRTKEEREALKKADCNEKFKKELLSADIIDDAWLAEIEAEHKDI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
INKATKAAEDAPYPSVEEAYAFVYEEGSLN
HHHHHHHHCCCCCCCHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]