Click here to switch to the map view.

The map label for this gene is bfmBAB [H]

Identifier: 82751121

GI number: 82751121

Start: 1511988

End: 1512971

Strand: Reverse

Name: bfmBAB [H]

Synonym: SAB1389c

Alternate gene names: 82751121

Gene position: 1512971-1511988 (Counterclockwise)

Preceding gene: 82751122

Following gene: 82751120

Centisome position: 55.17

GC content: 34.96

Gene sequence:

>984_bases
ATGGATAAATTATCTTATTTAGAGGCGATTCGCCAGGCACAAGACTTAGCATTACAACAAAATAAAGATGTATTTATTCT
TGGTGAAGATGTTGGTAAAAAAGGTGGCGTATTTGGTACTACTCAAGGACTGCAACAACAATATGGTGAGGACAGAGTTA
TCGATACACCATTAGCTGAGTCAAATATTGTCGGAACAGCCATTGGCGCAGCTATGGTTGGTAAAAGACCAATTGCTGAG
ATTCAGTTTGCAGATTTTATCTTACCTGCAACAAATCAAATTATTAGTGAAGCCGCGAAAATGCGTTATCGTTCAAATAA
TGAATGGCAATGCCCATTAACGATTCGTGCACCATTTGGTGGCGGTGTTCATGGTGGACTTTATCATTCACAAAGTATTG
AAAGTATATTTGCTTCATCACCAGGTTTAACAATTGTTATACCTTCAACACCGTATGATGCTAAAGGTCTATTATTATCT
TCAATTGAATCAAATGATCCTGTTTTATACTTTGAACATAAAAAGGCTTATAGATTCTTAAAGGAAGAAGTGCCAGAAGA
ATATTACACTGTACCTTTAGGAAAAGCAGATGTTAAACGTGAAGGTGAAGATTTAACAGTATTTTGTTATGGATTAATGG
TCAATTATTGTTTACAAGCCGCTGATATTTTAGCTGCAGATGGTATCAATGTTGAAGTCGTAGATTTACGAACTGTTTAT
CCATTAGATAAAGAAACAATTATTGATCGTGCTAAACATACAGGTAAAGTTTTACTTGTAACTGAAGATAATTTAGAAGG
TAGTATTATGTCTGAGGTGTCAGCGATTATTGCAGAACATTGTCTGTTTGAACTAGATGCACCGATCATGCGTTTAGCTG
CTCCAGATGTACCATCTATGCCATTTTCACCTGTATTAGAAAATGAAATTATGATGAATCCAGAAAAAATCTTAAATAAA
ATGCGTGAATTAGCAGAATTCTAG

Upstream 100 bases:

>100_bases
AAGACATTATCAATAAAGCGACAAAGGCTGCTGAAGACGCGCCATATCCAAGTGTCGAAGAAGCCTATGCATTTGTGTAT
GAAGAAGGGAGTCTTAACTA

Downstream 100 bases:

>100_bases
GGAGGGAAAGTCATGGAAATAACAATGCCTAAGTTAGGTGAGAGTGTTCATGAAGGTACCATTGAACAATGGTTAGTTTC
TGTTGGTGATCATATTGATG

Product: 2-oxoisovalerate dehydrogenase beta subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MDKLSYLEAIRQAQDLALQQNKDVFILGEDVGKKGGVFGTTQGLQQQYGEDRVIDTPLAESNIVGTAIGAAMVGKRPIAE
IQFADFILPATNQIISEAAKMRYRSNNEWQCPLTIRAPFGGGVHGGLYHSQSIESIFASSPGLTIVIPSTPYDAKGLLLS
SIESNDPVLYFEHKKAYRFLKEEVPEEYYTVPLGKADVKREGEDLTVFCYGLMVNYCLQAADILAADGINVEVVDLRTVY
PLDKETIIDRAKHTGKVLLVTEDNLEGSIMSEVSAIIAEHCLFELDAPIMRLAAPDVPSMPFSPVLENEIMMNPEKILNK
MRELAEF

Sequences:

>Translated_327_residues
MDKLSYLEAIRQAQDLALQQNKDVFILGEDVGKKGGVFGTTQGLQQQYGEDRVIDTPLAESNIVGTAIGAAMVGKRPIAE
IQFADFILPATNQIISEAAKMRYRSNNEWQCPLTIRAPFGGGVHGGLYHSQSIESIFASSPGLTIVIPSTPYDAKGLLLS
SIESNDPVLYFEHKKAYRFLKEEVPEEYYTVPLGKADVKREGEDLTVFCYGLMVNYCLQAADILAADGINVEVVDLRTVY
PLDKETIIDRAKHTGKVLLVTEDNLEGSIMSEVSAIIAEHCLFELDAPIMRLAAPDVPSMPFSPVLENEIMMNPEKILNK
MRELAEF
>Mature_327_residues
MDKLSYLEAIRQAQDLALQQNKDVFILGEDVGKKGGVFGTTQGLQQQYGEDRVIDTPLAESNIVGTAIGAAMVGKRPIAE
IQFADFILPATNQIISEAAKMRYRSNNEWQCPLTIRAPFGGGVHGGLYHSQSIESIFASSPGLTIVIPSTPYDAKGLLLS
SIESNDPVLYFEHKKAYRFLKEEVPEEYYTVPLGKADVKREGEDLTVFCYGLMVNYCLQAADILAADGINVEVVDLRTVY
PLDKETIIDRAKHTGKVLLVTEDNLEGSIMSEVSAIIAEHCLFELDAPIMRLAAPDVPSMPFSPVLENEIMMNPEKILNK
MRELAEF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=43.4250764525994, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=43.4250764525994, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI156564403, Length=310, Percent_Identity=36.1290322580645, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI291084858, Length=310, Percent_Identity=35.1612903225806, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI133778974, Length=260, Percent_Identity=29.6153846153846, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI205277463, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI4507521, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786622, Length=248, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506935, Length=299, Percent_Identity=41.4715719063545, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=34.2592592592593, Blast_Score=203, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=34.0490797546012, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=44.3425076452599, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=44.3425076452599, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21358145, Length=313, Percent_Identity=36.4217252396166, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24650940, Length=313, Percent_Identity=36.4217252396166, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24645119, Length=284, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45551847, Length=284, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550715, Length=284, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36106; Mature: 36106

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLSYLEAIRQAQDLALQQNKDVFILGEDVGKKGGVFGTTQGLQQQYGEDRVIDTPLAE
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCC
SNIVGTAIGAAMVGKRPIAEIQFADFILPATNQIISEAAKMRYRSNNEWQCPLTIRAPFG
CCCHHHHHHHHHHCCCCCHHEEHHHEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGVHGGLYHSQSIESIFASSPGLTIVIPSTPYDAKGLLLSSIESNDPVLYFEHKKAYRFL
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCEEEEEHHHHHHHH
KEEVPEEYYTVPLGKADVKREGEDLTVFCYGLMVNYCLQAADILAADGINVEVVDLRTVY
HHHCCHHHEECCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHEECCCCEEEEEEEEEC
PLDKETIIDRAKHTGKVLLVTEDNLEGSIMSEVSAIIAEHCLFELDAPIMRLAAPDVPSM
CCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
PFSPVLENEIMMNPEKILNKMRELAEF
CCCHHHCHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKLSYLEAIRQAQDLALQQNKDVFILGEDVGKKGGVFGTTQGLQQQYGEDRVIDTPLAE
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCC
SNIVGTAIGAAMVGKRPIAEIQFADFILPATNQIISEAAKMRYRSNNEWQCPLTIRAPFG
CCCHHHHHHHHHHCCCCCHHEEHHHEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGVHGGLYHSQSIESIFASSPGLTIVIPSTPYDAKGLLLSSIESNDPVLYFEHKKAYRFL
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCEEEEEHHHHHHHH
KEEVPEEYYTVPLGKADVKREGEDLTVFCYGLMVNYCLQAADILAADGINVEVVDLRTVY
HHHCCHHHEECCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHEECCCCEEEEEEEEEC
PLDKETIIDRAKHTGKVLLVTEDNLEGSIMSEVSAIIAEHCLFELDAPIMRLAAPDVPSM
CCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
PFSPVLENEIMMNPEKILNKMRELAEF
CCCHHHCHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]