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The map label for this gene is norA

Identifier: 82750397

GI number: 82750397

Start: 708751

End: 709917

Strand: Direct

Name: norA

Synonym: SAB0644

Alternate gene names: 82750397

Gene position: 708751-709917 (Clockwise)

Preceding gene: 82750393

Following gene: 82750398

Centisome position: 25.84

GC content: 32.73

Gene sequence:

>1167_bases
ATGAATAAACAGATTTTGGTATTATATTTTAATATTTTCTTAATTTTTTTAGGTATTGGTCTAGTGATACCAGTCTTACC
TGTTTATTTAAAAGATTTGGGGTTAACTGGTAGTGATTTAGGATTATTAGTTGCTGCTTTCGCCTTATCTCAAATGATTA
TATCGCCATTCGGTGGTACGTTAGCTGATAAATTAGGAAAGAAATTAATTATATATATAGGATTAATTTTGTTTTCAGTG
TCAGAATTTATGTTTGCTATCGGTCAGAATTTTTTAATTTTGATGTTATCAAGGGTTATCGGTGGTATGAGTGCTGGTAT
GGTTATGCCTGGGGTGACAGGTTTAATAGCTGACATTTCACCAAGCCATCAAAAAGCAAAAAACTTTGGCTACATGTCAG
CGATTATCAATTCAGGATTCATTTTAGGACCAGGGATTGGTGGATTTATGGCAGAAGTTTCACATCGTATGCCATTTTAT
TTTGCAGGTGCATTAGGTATTCTAGCATTTATAATGTCAATTGTATTGATTCACGACCCTAAAAAAGTTTCGACAAATGG
ATTCCAAAAGTTGGAGCCACAATTGCTAACGAAAATTAACTGGAAAGTGTTTATTACACCAGTTATTCTAACACTTGTAT
TATCGTTTGGTTTATCTGCATTTGAAACATTGTATTCACTATACACAGCTGACAAGGTAAATTATTCACCTAAAGATATT
TCGATTGCTATTACAGGTGGCGGTATATTTGGGGCACTTTTCCAAATCTATTTCTTCGATAAATTTATGAAGTATTTCTC
AGAGTTAACATTTATAGCTTGGTCATTATTATATTCAGTTGTTGTCTTAATATTATTAGTTTTTGCTAATGGCTATTGGT
CAATAATGTTAATCAGTTTTGTTGTCTTCATAGGTTTCGATATGATACGACCAGCCATTACAAATTATTTTTCTAATATT
GCTGGAGAAAGGCAAGGCTTTGCAGGCGGATTGAACTCGACATTCACTAGTATGGGTAATTTCATAGGTCCTTTAATCGC
AGGTGCGTTATTTGATGTACACATTGAAGCACCAATTTATATGGCTATAGGTGTTTCATTAGCAGGTGTTATTATTGTTT
TAATTGAAAAGCAGCATAGATCAAAATTGAAAGAACAAAATATGTAG

Upstream 100 bases:

>100_bases
TATAGAAACTTTTTACGAATATTTAGCATGAATTGCAATCTGTCGTGGAAAAGAAAAATAACAGCTTTAAGAGTGACAAG
TAGAAAAAAGAGGTGAGCAA

Downstream 100 bases:

>100_bases
CATAAGTATTTTGGTGTATATTGATATAAAGTAAAGCGTAATATTATGAATGATTAGCATCGTTTTTCTTATGAATTTTA
TTAAGAAAATTCGATGCTTT

Product: quinolone resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIIYIGLILFSV
SEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFY
FAGALGILAFIMSIVLIHDPKKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNI
AGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVIIVLIEKQHRSKLKEQNM

Sequences:

>Translated_388_residues
MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIIYIGLILFSV
SEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFY
FAGALGILAFIMSIVLIHDPKKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNI
AGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVIIVLIEKQHRSKLKEQNM
>Mature_388_residues
MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIIYIGLILFSV
SEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFY
FAGALGILAFIMSIVLIHDPKKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNI
AGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVIIVLIEKQHRSKLKEQNM

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=437, Percent_Identity=20.3661327231121, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787291, Length=363, Percent_Identity=23.9669421487603, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42392; Mature: 42392

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHH
LADKLGKKLIIYIGLILFSVSEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHCCC
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
CCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
KKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
CCCCCCCHHHHCHHHHHHCCHHEEHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCE
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHH
MAIGVSLAGVIIVLIEKQHRSKLKEQNM
HHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHH
LADKLGKKLIIYIGLILFSVSEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHCCC
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
CCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
KKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
CCCCCCCHHHHCHHHHHHCCHHEEHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCE
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHH
MAIGVSLAGVIIVLIEKQHRSKLKEQNM
HHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA