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The map label for this gene is phr [H]

Identifier: 82750393

GI number: 82750393

Start: 705584

End: 706963

Strand: Direct

Name: phr [H]

Synonym: SAB0640

Alternate gene names: 82750393

Gene position: 705584-706963 (Clockwise)

Preceding gene: 82750392

Following gene: 82750397

Centisome position: 25.73

GC content: 32.39

Gene sequence:

>1380_bases
TTGTTTATGGCAATAGCTGTGTTATTAAATCGTATGTTTCGAACAGAACATAATCCGTTATTTGAATATATTTATCAACA
AAAAGATGATATTGATGCTTGTTATTTCATTATTGCAGAAGAGGATATGAGTACAGCATCTGATTTGAAAGCACAATTTT
ATCGCGGTACTTTGCAGCGCTTTTACCAATCGTTGCACGCAGAAAAGCTCACACCTTATGTCATGTCTTATGACGATATC
ATTTCATTTTGTAAAGAAAACAATATCTCTGAAGTAGTGATTGCGGGTGATATTATGAGTTATCATCTTGAAGAATATGA
TATTTTACATCAACGCTCTTTATTCAATGAAGCACGCATTGCCGTTACTTTGATACGTGGTAATCATTATTTTAAAGCGA
GTAAAACGATGAATCAACAAGGGGAGCCATACAAAGTTTTTACTAGTTTTTATAAAAAATGGCGACCGTATTTGAGAATT
AGAGATGTATATCATTACGACTTAAATGAGTTAATTGACATTGTAATTGCAGCTCCTAATAATTTAAAAGATGTCCAAAT
AGGTGCTGGTTCATCACAAGCGCATGAACAAGAAAAATGGCAACAATTTTTAGAACATGATATACAGAATTATGAAAATG
GCAGAGAATATTTACCAGAAATATTAACAAGTCAATTAAGCATTGCCTTAGCATATGGCTTATTAGATATTATTGAAATT
TTCAATGATTTGTTATCACGATATGAAGAAGATGAGTCAAACTATGAAGCGTTTATTCGGGAGCTCATTTTTAGAGAGTT
TTATTATGTTTTAATGACACAATATCCGGAGTCTGCACATCAATCTTTTAAACCGAAATATCGTCATATTAATTGGTCTG
AAAACGAAGCGGATTTTAAAGCTTGGTGTGATGGTCAAACGGGATTTCCAATAATTGATGCAGCAATGATGGAATTGAGA
CAAACAGGTTTTATGCATAATCGTATGAGAATGGTTGTGTCTCAATTTTTAACAAAAAATTTATTTATAAATTGGACATG
GGGAGAGGATTTCTTCAGAAAGTATCTTATAGATTATGATTCAGCATCAAATGTTCATGGTTGGCAATGGTCTGCATCTA
CTGGTACGGATGCGGTGCCGTATTTTAGAATGTTTAATCCAATTAGGCAGAGTGAACGCTTTGATCCTAAAGCATTATAT
ATCAAAACATATCTTCCAGTTTTAAATCAAATTGATGCAAAGTATTTACATGACACACATCAAAATGAATCTGAATTATT
TAAACAAGGGATTGAGTTAGGTCGTCATTATCCAAAACAAATAGTGGATCATCAAGAAAAGAGATCTCAAGTTTTAGCGA
CATTTAAAACATTAGACTAA

Upstream 100 bases:

>100_bases
AAATGGTTAGGTTTGCTTTAATTAAAAATATAAATAAGAATCTAGGTTATTTTAAAGTGACAAAAAGCTTAATAAAATAA
AAAGATAATTGAAGGGTGTT

Downstream 100 bases:

>100_bases
TTGATGGCCCAACTAAAATAAAACAAGCTAACTAAGACATGTTTTGCCATAGTTAGCTTGTTTAAATTGTTCTATCGGAA
TATGTCAGTAAACATAGTGA

Product: DNA photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MFMAIAVLLNRMFRTEHNPLFEYIYQQKDDIDACYFIIAEEDMSTASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDI
ISFCKENNISEVVIAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYKVFTSFYKKWRPYLRI
RDVYHYDLNELIDIVIAAPNNLKDVQIGAGSSQAHEQEKWQQFLEHDIQNYENGREYLPEILTSQLSIALAYGLLDIIEI
FNDLLSRYEEDESNYEAFIRELIFREFYYVLMTQYPESAHQSFKPKYRHINWSENEADFKAWCDGQTGFPIIDAAMMELR
QTGFMHNRMRMVVSQFLTKNLFINWTWGEDFFRKYLIDYDSASNVHGWQWSASTGTDAVPYFRMFNPIRQSERFDPKALY
IKTYLPVLNQIDAKYLHDTHQNESELFKQGIELGRHYPKQIVDHQEKRSQVLATFKTLD

Sequences:

>Translated_459_residues
MFMAIAVLLNRMFRTEHNPLFEYIYQQKDDIDACYFIIAEEDMSTASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDI
ISFCKENNISEVVIAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYKVFTSFYKKWRPYLRI
RDVYHYDLNELIDIVIAAPNNLKDVQIGAGSSQAHEQEKWQQFLEHDIQNYENGREYLPEILTSQLSIALAYGLLDIIEI
FNDLLSRYEEDESNYEAFIRELIFREFYYVLMTQYPESAHQSFKPKYRHINWSENEADFKAWCDGQTGFPIIDAAMMELR
QTGFMHNRMRMVVSQFLTKNLFINWTWGEDFFRKYLIDYDSASNVHGWQWSASTGTDAVPYFRMFNPIRQSERFDPKALY
IKTYLPVLNQIDAKYLHDTHQNESELFKQGIELGRHYPKQIVDHQEKRSQVLATFKTLD
>Mature_459_residues
MFMAIAVLLNRMFRTEHNPLFEYIYQQKDDIDACYFIIAEEDMSTASDLKAQFYRGTLQRFYQSLHAEKLTPYVMSYDDI
ISFCKENNISEVVIAGDIMSYHLEEYDILHQRSLFNEARIAVTLIRGNHYFKASKTMNQQGEPYKVFTSFYKKWRPYLRI
RDVYHYDLNELIDIVIAAPNNLKDVQIGAGSSQAHEQEKWQQFLEHDIQNYENGREYLPEILTSQLSIALAYGLLDIIEI
FNDLLSRYEEDESNYEAFIRELIFREFYYVLMTQYPESAHQSFKPKYRHINWSENEADFKAWCDGQTGFPIIDAAMMELR
QTGFMHNRMRMVVSQFLTKNLFINWTWGEDFFRKYLIDYDSASNVHGWQWSASTGTDAVPYFRMFNPIRQSERFDPKALY
IKTYLPVLNQIDAKYLHDTHQNESELFKQGIELGRHYPKQIVDHQEKRSQVLATFKTLD

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=246, Percent_Identity=32.9268292682927, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI188536100, Length=273, Percent_Identity=30.03663003663, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI188536103, Length=273, Percent_Identity=29.3040293040293, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786926, Length=408, Percent_Identity=34.0686274509804, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6324962, Length=469, Percent_Identity=29.8507462686567, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137248, Length=235, Percent_Identity=33.1914893617021, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585455, Length=235, Percent_Identity=33.1914893617021, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648152, Length=202, Percent_Identity=30.6930693069307, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54605; Mature: 54605

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMAIAVLLNRMFRTEHNPLFEYIYQQKDDIDACYFIIAEEDMSTASDLKAQFYRGTLQR
CHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
FYQSLHAEKLTPYVMSYDDIISFCKENNISEVVIAGDIMSYHLEEYDILHQRSLFNEARI
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEE
AVTLIRGNHYFKASKTMNQQGEPYKVFTSFYKKWRPYLRIRDVYHYDLNELIDIVIAAPN
EEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCC
NLKDVQIGAGSSQAHEQEKWQQFLEHDIQNYENGREYLPEILTSQLSIALAYGLLDIIEI
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNDLLSRYEEDESNYEAFIRELIFREFYYVLMTQYPESAHQSFKPKYRHINWSENEADFK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCHH
AWCDGQTGFPIIDAAMMELRQTGFMHNRMRMVVSQFLTKNLFINWTWGEDFFRKYLIDYD
HEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCC
SASNVHGWQWSASTGTDAVPYFRMFNPIRQSERFDPKALYIKTYLPVLNQIDAKYLHDTH
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QNESELFKQGIELGRHYPKQIVDHQEKRSQVLATFKTLD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFMAIAVLLNRMFRTEHNPLFEYIYQQKDDIDACYFIIAEEDMSTASDLKAQFYRGTLQR
CHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
FYQSLHAEKLTPYVMSYDDIISFCKENNISEVVIAGDIMSYHLEEYDILHQRSLFNEARI
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEE
AVTLIRGNHYFKASKTMNQQGEPYKVFTSFYKKWRPYLRIRDVYHYDLNELIDIVIAAPN
EEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCC
NLKDVQIGAGSSQAHEQEKWQQFLEHDIQNYENGREYLPEILTSQLSIALAYGLLDIIEI
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNDLLSRYEEDESNYEAFIRELIFREFYYVLMTQYPESAHQSFKPKYRHINWSENEADFK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCHH
AWCDGQTGFPIIDAAMMELRQTGFMHNRMRMVVSQFLTKNLFINWTWGEDFFRKYLIDYD
HEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCC
SASNVHGWQWSASTGTDAVPYFRMFNPIRQSERFDPKALYIKTYLPVLNQIDAKYLHDTH
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QNESELFKQGIELGRHYPKQIVDHQEKRSQVLATFKTLD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]