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The map label for this gene is serA [H]

Identifier: 82703309

GI number: 82703309

Start: 2489066

End: 2490265

Strand: Direct

Name: serA [H]

Synonym: Nmul_A2191

Alternate gene names: 82703309

Gene position: 2489066-2490265 (Clockwise)

Preceding gene: 82703308

Following gene: 82703310

Centisome position: 78.17

GC content: 54.5

Gene sequence:

>1200_bases
ATGCCTGAACGTGCACATAAAATCTTCCGGATACTGACCCTCAACCAGATTTCGCCGCTGGGCCTCAAGCTTTTCAGTTC
CAGCCATTATAAAGTGGGCAGCGACACAACCGAGCCCGATGCGATTCTGGTGCGCTCCCACAATATGCTGGACATGGATA
TTCCTCCCAGCGTGAAAGCAATAGGCCGGGCCGGGGCAGGCACGAACAACGTACCGGTCAGCGCCATGAACCTGCGCGGG
GTGCCCGTTTTCAATGCGCCGGGAGCCAATGCCAACGCAGTCAAGGAACTGGTGCTGGCAGGCCTGCTGATCGCTTCCCG
TAACCTGATTCCGGCGATTCATTTCACCGAAAAACTGGAAGGCGATAACGAGACCCTGAACAGGCTGTCTGAGAACGGCA
AAAAGCAGTTTGCTGGCATCGAACTGCCCAGACGTACGCTGGGCATCATTGGCCTGGGCGCAATAGGACGCCTGGTGGCT
GATGCAGCGCTTCGGCTTGGCATGAAGGTGATGGGATATGATCCCAATATCACCGTGGATGCAGCCTGGAACCTGTCCTC
GGAGGTCAAGCGCGCGGAAAGCATCGAAGATTTGTTGCGCAACAGCGAGTTTGTAACATTGCACGTACCCCTGCTAGATT
CGACCCGGCACCTCGTCAACCGGCAGGTTGTGCAAAGCATGAGAAACAGTACGATTCTGCTCAACTTTTCGCGTGACGGC
ATCGTGGATGAAAATGCCGTGCTCGAAGGAATCGAGATGGGGAAGATAAAATATTACGTAAGCGATTTCCCCAGCGAAAA
GCTTCAACATCATGCAAGGGTTATCACCCTGCCGCATCTGGGCGCATCCACTCAGGAAGCGGAAGAGAATTGCGCGGTAA
TGGTGACGAAGCAGGTAATCGATTATCTGGAGAACGGCGGCATTACCAATGCAGTCAACTTCCCCAATATAACAATGGAG
CGGGAATCCCCTTATCGACTCGCCGTTGCGAATGCCAACGTACCGAACATGGTGGGGCAAATTTCCACCGCCATGGCGAA
AGCCGGTCTCAATATCCACACCATGGGTAACAAGTCTCGCGGCGAAATGGCCTACACCCTGGTGGATGTCGACAGTCCGG
TACCCCAGGAAACGATCGACGAGATTGCGGCGATAAAGGGTGTGTTGAATGTACGCTACCTGCCGGTACCGGCCAAATAG

Upstream 100 bases:

>100_bases
CATCGTTCTGTCGGCGGCATGCGCGCTTCGATATACAATGCGATGCCGCTTGAAGGCGTAAAGGTCTTGGTGGAATTCAT
GAAGGAATTTGCGAGCAATC

Downstream 100 bases:

>100_bases
CTGCCATTTCATGTCATAGCTTTGGCAGGTACGGTTCAAAACAGAAATTATCCCGCGATGACCGCTCAACTCAAACAGCT
GCGCGACAAGATAGATGCAA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPERAHKIFRILTLNQISPLGLKLFSSSHYKVGSDTTEPDAILVRSHNMLDMDIPPSVKAIGRAGAGTNNVPVSAMNLRG
VPVFNAPGANANAVKELVLAGLLIASRNLIPAIHFTEKLEGDNETLNRLSENGKKQFAGIELPRRTLGIIGLGAIGRLVA
DAALRLGMKVMGYDPNITVDAAWNLSSEVKRAESIEDLLRNSEFVTLHVPLLDSTRHLVNRQVVQSMRNSTILLNFSRDG
IVDENAVLEGIEMGKIKYYVSDFPSEKLQHHARVITLPHLGASTQEAEENCAVMVTKQVIDYLENGGITNAVNFPNITME
RESPYRLAVANANVPNMVGQISTAMAKAGLNIHTMGNKSRGEMAYTLVDVDSPVPQETIDEIAAIKGVLNVRYLPVPAK

Sequences:

>Translated_399_residues
MPERAHKIFRILTLNQISPLGLKLFSSSHYKVGSDTTEPDAILVRSHNMLDMDIPPSVKAIGRAGAGTNNVPVSAMNLRG
VPVFNAPGANANAVKELVLAGLLIASRNLIPAIHFTEKLEGDNETLNRLSENGKKQFAGIELPRRTLGIIGLGAIGRLVA
DAALRLGMKVMGYDPNITVDAAWNLSSEVKRAESIEDLLRNSEFVTLHVPLLDSTRHLVNRQVVQSMRNSTILLNFSRDG
IVDENAVLEGIEMGKIKYYVSDFPSEKLQHHARVITLPHLGASTQEAEENCAVMVTKQVIDYLENGGITNAVNFPNITME
RESPYRLAVANANVPNMVGQISTAMAKAGLNIHTMGNKSRGEMAYTLVDVDSPVPQETIDEIAAIKGVLNVRYLPVPAK
>Mature_398_residues
PERAHKIFRILTLNQISPLGLKLFSSSHYKVGSDTTEPDAILVRSHNMLDMDIPPSVKAIGRAGAGTNNVPVSAMNLRGV
PVFNAPGANANAVKELVLAGLLIASRNLIPAIHFTEKLEGDNETLNRLSENGKKQFAGIELPRRTLGIIGLGAIGRLVAD
AALRLGMKVMGYDPNITVDAAWNLSSEVKRAESIEDLLRNSEFVTLHVPLLDSTRHLVNRQVVQSMRNSTILLNFSRDGI
VDENAVLEGIEMGKIKYYVSDFPSEKLQHHARVITLPHLGASTQEAEENCAVMVTKQVIDYLENGGITNAVNFPNITMER
ESPYRLAVANANVPNMVGQISTAMAKAGLNIHTMGNKSRGEMAYTLVDVDSPVPQETIDEIAAIKGVLNVRYLPVPAK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=32.312925170068, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI61743967, Length=286, Percent_Identity=27.972027972028, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4557497, Length=286, Percent_Identity=27.972027972028, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI145580578, Length=248, Percent_Identity=27.8225806451613, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557499, Length=248, Percent_Identity=27.8225806451613, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=28.099173553719, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789279, Length=369, Percent_Identity=30.8943089430894, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=26.7657992565056, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787645, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=275, Percent_Identity=32, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=201, Percent_Identity=25.8706467661692, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=413, Percent_Identity=26.634382566586, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=411, Percent_Identity=26.2773722627737, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=288, Percent_Identity=26.0416666666667, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=224, Percent_Identity=26.3392857142857, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=276, Percent_Identity=35.1449275362319, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24646446, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646448, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646452, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646450, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=27.3408239700375, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574286, Length=255, Percent_Identity=26.2745098039216, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574284, Length=272, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=23.8095238095238, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=20.4724409448819, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43394; Mature: 43262

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERAHKIFRILTLNQISPLGLKLFSSSHYKVGSDTTEPDAILVRSHNMLDMDIPPSVKA
CCHHHHHHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCCEEEEECCCEEECCCCCCHHH
IGRAGAGTNNVPVSAMNLRGVPVFNAPGANANAVKELVLAGLLIASRNLIPAIHFTEKLE
HHCCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCC
GDNETLNRLSENGKKQFAGIELPRRTLGIIGLGAIGRLVADAALRLGMKVMGYDPNITVD
CCHHHHHHHHHCCCCEECCCCCCHHHHCEEEHHHHHHHHHHHHHHCCCEEECCCCCEEEE
AAWNLSSEVKRAESIEDLLRNSEFVTLHVPLLDSTRHLVNRQVVQSMRNSTILLNFSRDG
EECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCC
IVDENAVLEGIEMGKIKYYVSDFPSEKLQHHARVITLPHLGASTQEAEENCAVMVTKQVI
CCCCHHHHCCCEECEEEEEECCCCHHHHHCCCEEEEECCCCCCCHHHHCCCEEEEHHHHH
DYLENGGITNAVNFPNITMERESPYRLAVANANVPNMVGQISTAMAKAGLNIHTMGNKSR
HHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCC
GEMAYTLVDVDSPVPQETIDEIAAIKGVLNVRYLPVPAK
CCEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCC
>Mature Secondary Structure 
PERAHKIFRILTLNQISPLGLKLFSSSHYKVGSDTTEPDAILVRSHNMLDMDIPPSVKA
CHHHHHHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCCEEEEECCCEEECCCCCCHHH
IGRAGAGTNNVPVSAMNLRGVPVFNAPGANANAVKELVLAGLLIASRNLIPAIHFTEKLE
HHCCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCC
GDNETLNRLSENGKKQFAGIELPRRTLGIIGLGAIGRLVADAALRLGMKVMGYDPNITVD
CCHHHHHHHHHCCCCEECCCCCCHHHHCEEEHHHHHHHHHHHHHHCCCEEECCCCCEEEE
AAWNLSSEVKRAESIEDLLRNSEFVTLHVPLLDSTRHLVNRQVVQSMRNSTILLNFSRDG
EECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCC
IVDENAVLEGIEMGKIKYYVSDFPSEKLQHHARVITLPHLGASTQEAEENCAVMVTKQVI
CCCCHHHHCCCEECEEEEEECCCCHHHHHCCCEEEEECCCCCCCHHHHCCCEEEEHHHHH
DYLENGGITNAVNFPNITMERESPYRLAVANANVPNMVGQISTAMAKAGLNIHTMGNKSR
HHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCC
GEMAYTLVDVDSPVPQETIDEIAAIKGVLNVRYLPVPAK
CCEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]