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The map label for this gene is mtaD [H]

Identifier: 82703305

GI number: 82703305

Start: 2482949

End: 2484295

Strand: Reverse

Name: mtaD [H]

Synonym: Nmul_A2187

Alternate gene names: 82703305

Gene position: 2484295-2482949 (Counterclockwise)

Preceding gene: 82703306

Following gene: 82703304

Centisome position: 78.02

GC content: 56.05

Gene sequence:

>1347_bases
ATGATGGATCCGGTAAAAATCGATACGCTGCTGGAGGCACGCTGGATAATCCCGGTTGAGCCCGCGGGCGCGGTGCTTCA
TGGTCATGCCATTGCAATTGACCAGGGCATGATTCGCGCAATCCTGCCCCGCGCCGAGGCACACGTGCAATTCGAGCCGC
GCGAACGCGTCGTGATGAACAGCCACGCGCTCATTCCCGGCCTGATAAATCTCCACACGCATGCGGCCATGTCGCTGATG
CGAGGAATGGCAGATGACCTGCCTTTGATGGAGTGGCTAACCCATCATATCTGGCCGGCGGAAGCGAAGCACGTGGACCA
GGGTTTTGTTTTCGATGGTACGCGTCTGGCATGCGCCGAGATGCTGCAGGGTGGAGTTACCTGTTTCAATGACATGTACC
TGTTTCCGGAAGCCGCTGCGCGCGCCGCATTGGCCGCGGGCATGCGTGCCAGCATCGGCATGATCGCAATCGACTTTCCC
ACTGCCTACGCCAGCGATCCTGACGACTATCTGACCAAGGGTCTGGCGCTGCGGGACGATTACAATCCGCATTCCCTCCT
GTCATTCTGTTTTGCCCCACATGCGCCTTACACCGTAGGTGACAAGAATTTGTCCCGGGTTCTCACCTATGCAGAGCAGT
TGGATGTACCCATTCACATTCATCTGCACGAAACCGGGGATGAAATCGACAACAGCCTGAAAAGCTATGGAATGCGTCCC
CTTGAGCGCATTCACAAGCTCGGACTGCTCGGACCCAATCTGATTGCGGTACACATGGTGCATCTTACCGGGGGAGAAAT
CGAACTGCTGGCGCAGCAAGGCTGTTCCGTAGCCCATTGCCCTTCTTCCAACCTTAAACATGCGAGTGGGCTGGCACCCG
TTGCCGCTCTTATAGAAGCAGGCGTCAACGTAGGATTGGGAACGGATAGCGCTGCAAGTAACAGTCGGCTCAAGATGTTC
GAGGAAATGCGGCTTGCGGCACTCCTAGCAAAAGGACAAAGCGGGAGGGCAGAAGTGCTGCCTGCATGGCAGGTGCTGCA
AATGGCCACGCTCAACGGGGCCAGGGCTTTAGGGTTGGGAGACCGTATCGGTTCCCTTGTTCCAGGCAAAGCTGCGGATA
TTGCCGCCGTGGATTTCTCCAGTCTTGATATGGCGCCCTGCTATGACCCTGTTTCCCATCTTGTCTATGCTGCCGGACGT
GAACATGTGAGTCATGTGTGGGTAAATGGTAAAATGCTGCTGCGTGACTCGGAATTGACTACGCTGGACCGGGAAGAATT
GGTGCACAGGGCTGAATTCTGGCGGGAACAAATGACAACGGGCGTGATAGCAGTTCACGAAAAATGA

Upstream 100 bases:

>100_bases
GTACGAAGGAAACAGTACAATAATTCGATCCATATATAAAAAACGCAAAAAAATCAAACCCTGCCATCGCGGCAGGGTTT
TTTTTTGCTAAGCTTCCGCG

Downstream 100 bases:

>100_bases
TGGATAAAGAAATCGAAAATGGCAGTGTCAACGTTGATCTGCTGGAACTGGAAAAATTCAACCAGCTCGCGCATCGCTGG
TGGGATCCCAACAGTGAATT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MMDPVKIDTLLEARWIIPVEPAGAVLHGHAIAIDQGMIRAILPRAEAHVQFEPRERVVMNSHALIPGLINLHTHAAMSLM
RGMADDLPLMEWLTHHIWPAEAKHVDQGFVFDGTRLACAEMLQGGVTCFNDMYLFPEAAARAALAAGMRASIGMIAIDFP
TAYASDPDDYLTKGLALRDDYNPHSLLSFCFAPHAPYTVGDKNLSRVLTYAEQLDVPIHIHLHETGDEIDNSLKSYGMRP
LERIHKLGLLGPNLIAVHMVHLTGGEIELLAQQGCSVAHCPSSNLKHASGLAPVAALIEAGVNVGLGTDSAASNSRLKMF
EEMRLAALLAKGQSGRAEVLPAWQVLQMATLNGARALGLGDRIGSLVPGKAADIAAVDFSSLDMAPCYDPVSHLVYAAGR
EHVSHVWVNGKMLLRDSELTTLDREELVHRAEFWREQMTTGVIAVHEK

Sequences:

>Translated_448_residues
MMDPVKIDTLLEARWIIPVEPAGAVLHGHAIAIDQGMIRAILPRAEAHVQFEPRERVVMNSHALIPGLINLHTHAAMSLM
RGMADDLPLMEWLTHHIWPAEAKHVDQGFVFDGTRLACAEMLQGGVTCFNDMYLFPEAAARAALAAGMRASIGMIAIDFP
TAYASDPDDYLTKGLALRDDYNPHSLLSFCFAPHAPYTVGDKNLSRVLTYAEQLDVPIHIHLHETGDEIDNSLKSYGMRP
LERIHKLGLLGPNLIAVHMVHLTGGEIELLAQQGCSVAHCPSSNLKHASGLAPVAALIEAGVNVGLGTDSAASNSRLKMF
EEMRLAALLAKGQSGRAEVLPAWQVLQMATLNGARALGLGDRIGSLVPGKAADIAAVDFSSLDMAPCYDPVSHLVYAAGR
EHVSHVWVNGKMLLRDSELTTLDREELVHRAEFWREQMTTGVIAVHEK
>Mature_448_residues
MMDPVKIDTLLEARWIIPVEPAGAVLHGHAIAIDQGMIRAILPRAEAHVQFEPRERVVMNSHALIPGLINLHTHAAMSLM
RGMADDLPLMEWLTHHIWPAEAKHVDQGFVFDGTRLACAEMLQGGVTCFNDMYLFPEAAARAALAAGMRASIGMIAIDFP
TAYASDPDDYLTKGLALRDDYNPHSLLSFCFAPHAPYTVGDKNLSRVLTYAEQLDVPIHIHLHETGDEIDNSLKSYGMRP
LERIHKLGLLGPNLIAVHMVHLTGGEIELLAQQGCSVAHCPSSNLKHASGLAPVAALIEAGVNVGLGTDSAASNSRLKMF
EEMRLAALLAKGQSGRAEVLPAWQVLQMATLNGARALGLGDRIGSLVPGKAADIAAVDFSSLDMAPCYDPVSHLVYAAGR
EHVSHVWVNGKMLLRDSELTTLDREELVHRAEFWREQMTTGVIAVHEK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=445, Percent_Identity=24.9438202247191, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789249, Length=344, Percent_Identity=28.7790697674419, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082177, Length=430, Percent_Identity=24.6511627906977, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540282, Length=385, Percent_Identity=24.9350649350649, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319963, Length=349, Percent_Identity=24.6418338108883, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24643849, Length=381, Percent_Identity=28.3464566929134, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48721; Mature: 48721

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDPVKIDTLLEARWIIPVEPAGAVLHGHAIAIDQGMIRAILPRAEAHVQFEPRERVVMN
CCCCCCHHHHHHEEEEEEECCCCCEEECCEEEECCHHHHHHHCCCCCEEEECCCHHEEEC
SHALIPGLINLHTHAAMSLMRGMADDLPLMEWLTHHIWPAEAKHVDQGFVFDGTRLACAE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCEECCHHHHHHH
MLQGGVTCFNDMYLFPEAAARAALAAGMRASIGMIAIDFPTAYASDPDDYLTKGLALRDD
HHHCCCEEECCEEECHHHHHHHHHHHCHHHCCCEEEEECCCCCCCCCHHHHHCCCEECCC
YNPHSLLSFCFAPHAPYTVGDKNLSRVLTYAEQLDVPIHIHLHETGDEIDNSLKSYGMRP
CCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCH
LERIHKLGLLGPNLIAVHMVHLTGGEIELLAQQGCSVAHCPSSNLKHASGLAPVAALIEA
HHHHHHHCCCCCCEEEEEEEEECCCCEEEEHHCCCCEEECCCCCCCCCCCHHHHHHHHHC
GVNVGLGTDSAASNSRLKMFEEMRLAALLAKGQSGRAEVLPAWQVLQMATLNGARALGLG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCH
DRIGSLVPGKAADIAAVDFSSLDMAPCYDPVSHLVYAAGREHVSHVWVNGKMLLRDSELT
HHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHEEEEECCEEEEECCCCC
TLDREELVHRAEFWREQMTTGVIAVHEK
CCCHHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MMDPVKIDTLLEARWIIPVEPAGAVLHGHAIAIDQGMIRAILPRAEAHVQFEPRERVVMN
CCCCCCHHHHHHEEEEEEECCCCCEEECCEEEECCHHHHHHHCCCCCEEEECCCHHEEEC
SHALIPGLINLHTHAAMSLMRGMADDLPLMEWLTHHIWPAEAKHVDQGFVFDGTRLACAE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCEECCHHHHHHH
MLQGGVTCFNDMYLFPEAAARAALAAGMRASIGMIAIDFPTAYASDPDDYLTKGLALRDD
HHHCCCEEECCEEECHHHHHHHHHHHCHHHCCCEEEEECCCCCCCCCHHHHHCCCEECCC
YNPHSLLSFCFAPHAPYTVGDKNLSRVLTYAEQLDVPIHIHLHETGDEIDNSLKSYGMRP
CCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCH
LERIHKLGLLGPNLIAVHMVHLTGGEIELLAQQGCSVAHCPSSNLKHASGLAPVAALIEA
HHHHHHHCCCCCCEEEEEEEEECCCCEEEEHHCCCCEEECCCCCCCCCCCHHHHHHHHHC
GVNVGLGTDSAASNSRLKMFEEMRLAALLAKGQSGRAEVLPAWQVLQMATLNGARALGLG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCH
DRIGSLVPGKAADIAAVDFSSLDMAPCYDPVSHLVYAAGREHVSHVWVNGKMLLRDSELT
HHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHEEEEECCEEEEECCCCC
TLDREELVHRAEFWREQMTTGVIAVHEK
CCCHHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA