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The map label for this gene is ffh [H]

Identifier: 82703253

GI number: 82703253

Start: 2428110

End: 2429459

Strand: Direct

Name: ffh [H]

Synonym: Nmul_A2134

Alternate gene names: 82703253

Gene position: 2428110-2429459 (Clockwise)

Preceding gene: 82703247

Following gene: 82703257

Centisome position: 76.25

GC content: 55.56

Gene sequence:

>1350_bases
ATGTTTGACAATCTTACCAACCGGCTTTCAGGCGTCATCAAGACTTTGCGGGGTGAAGCACGGCTGACTGAAACCAATAT
ACAGGAAGCGCTGCGGGAAGTGCGCATGGCGCTGCTGGAAGCGGATGTCGCGCTGCCGGTAATCAAGGAATTCATTGCGC
GGGTGAAGGAAAAAGCAGTTGGCCAGGAAGTAATCGGCAGCCTTACGCCAGGACAGGCATTGGTGGGCGTAGTCCACCAG
GAACTGATCGCCCTCATGGGAGGCCAGAAAGCAGATATCAACCTTGCCACTGTCCCCCCTGCGGTGATTCTCATGGCGGG
GTTGCAGGGCGCCGGAAAAACCACGAGCAGCGGAAAGCTGGCGAAGTGGCTGATGGAACAAAAAAAGAAAAAAGTATTGC
TTGTCTCCTGCGATATCTATCGGCCAGCCGCAATTCAGCAACTGGAACTCCTGGCGCGACAAACGGGCGCCGAGTTCTTT
CCGGTTCAAGCCGGACAGCAGCCGAAAGAAATTGCAGCGGCTGCCCTCAACTTCGCACGTCGGCACTTTCATGATGTGAT
GATCGTGGATACGGCCGGACGCCTCGCCATCGACGAAGCAATGATGGCGGAAATCAGCGAGCTGGAAGCCTTGCTGAAAC
CCATCGAAACCTTGTTCGTGGTGGATGCCATGCAGGGGCAGGATGCCGTCAACACCGCCAAGGCATTTTCCGAAGCGCTG
CCCCTGACCGGCGTAGTACTGACAAAGCTGGATGGAGATGCGCGAGGCGGGGCAGCCCTTTCCGTGCTTCACGTAACGGG
GAAACCCATCAAATTCGCCGGTGTCGCCGAAAAACTGACCGGGTTGGAACCGTTTCATCCTGACCGTATGGCCTCACGGA
TTCTGGGAATGGGCGATGTACTGGGACTGATCGAGGAAGCCCAGCGCGGCGTGGATCAGCAGGAGGCCGAGAAACTTGCC
AAAAAGATGAAATCGGGCAAAAGCTTTGACCTGAACGATTTCAAGATGCAGTTTGAACAGATGAGGAACATGGGGGGCAT
GGGCGCGCTGATGGATAAATTGCCTGCTCAGTTGAGCCAGGCTGCCCAGAATGTGAAAGTCGATGATAAGGTTATCGGCC
GCACCGAAGGCATCATCAATTCCATGACGCCGCAGGAACGTCTCAAACCGGAAATCCTCAAAGCCTCGCGCAAGCGTCGT
ATTGCTGCAGGCGCAGGTGTCACGGTACAGGAAGTGAATCGACTGCTGGCGCAGTTCGAGCAGGCGCAAAAAATGATGAA
AATGATGAACAAGGGAGGCATGACGAAAATGCTGCGAAGCATGAAGGGAATGCTGCCCGGCATGCGCTGA

Upstream 100 bases:

>100_bases
CGAGATAGGCTAAAATATCGGACATTGATATTGCAGATTAAATGAAACTAAATGAAACCTTCATTTAGTCTACACCAATT
TTTCCGGAGAGGCATTTTGC

Downstream 100 bases:

>100_bases
AGGAACTCCTCCTTAACAAGCGCGAGGGCTGCGAGAGATACTGGCGTCGCCTTAGATCATTCCGCCGCCGGCACTTTTTC
GAGACCATTGATTCGCTGGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDNLTNRLSGVIKTLRGEARLTETNIQEALREVRMALLEADVALPVIKEFIARVKEKAVGQEVIGSLTPGQALVGVVHQ
ELIALMGGQKADINLATVPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIQQLELLARQTGAEFF
PVQAGQQPKEIAAAALNFARRHFHDVMIVDTAGRLAIDEAMMAEISELEALLKPIETLFVVDAMQGQDAVNTAKAFSEAL
PLTGVVLTKLDGDARGGAALSVLHVTGKPIKFAGVAEKLTGLEPFHPDRMASRILGMGDVLGLIEEAQRGVDQQEAEKLA
KKMKSGKSFDLNDFKMQFEQMRNMGGMGALMDKLPAQLSQAAQNVKVDDKVIGRTEGIINSMTPQERLKPEILKASRKRR
IAAGAGVTVQEVNRLLAQFEQAQKMMKMMNKGGMTKMLRSMKGMLPGMR

Sequences:

>Translated_449_residues
MFDNLTNRLSGVIKTLRGEARLTETNIQEALREVRMALLEADVALPVIKEFIARVKEKAVGQEVIGSLTPGQALVGVVHQ
ELIALMGGQKADINLATVPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIQQLELLARQTGAEFF
PVQAGQQPKEIAAAALNFARRHFHDVMIVDTAGRLAIDEAMMAEISELEALLKPIETLFVVDAMQGQDAVNTAKAFSEAL
PLTGVVLTKLDGDARGGAALSVLHVTGKPIKFAGVAEKLTGLEPFHPDRMASRILGMGDVLGLIEEAQRGVDQQEAEKLA
KKMKSGKSFDLNDFKMQFEQMRNMGGMGALMDKLPAQLSQAAQNVKVDDKVIGRTEGIINSMTPQERLKPEILKASRKRR
IAAGAGVTVQEVNRLLAQFEQAQKMMKMMNKGGMTKMLRSMKGMLPGMR
>Mature_449_residues
MFDNLTNRLSGVIKTLRGEARLTETNIQEALREVRMALLEADVALPVIKEFIARVKEKAVGQEVIGSLTPGQALVGVVHQ
ELIALMGGQKADINLATVPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIQQLELLARQTGAEFF
PVQAGQQPKEIAAAALNFARRHFHDVMIVDTAGRLAIDEAMMAEISELEALLKPIETLFVVDAMQGQDAVNTAKAFSEAL
PLTGVVLTKLDGDARGGAALSVLHVTGKPIKFAGVAEKLTGLEPFHPDRMASRILGMGDVLGLIEEAQRGVDQQEAEKLA
KKMKSGKSFDLNDFKMQFEQMRNMGGMGALMDKLPAQLSQAAQNVKVDDKVIGRTEGIINSMTPQERLKPEILKASRKRR
IAAGAGVTVQEVNRLLAQFEQAQKMMKMMNKGGMTKMLRSMKGMLPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=29.8440979955457, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=31.7919075144509, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=28.8961038961039, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=28.8961038961039, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI89061728, Length=150, Percent_Identity=37.3333333333333, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1788963, Length=448, Percent_Identity=66.9642857142857, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=34.3396226415094, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=456, Percent_Identity=28.5087719298246, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=30.7432432432432, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=423, Percent_Identity=31.2056737588652, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=26.2658227848101, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647949, Length=453, Percent_Identity=29.1390728476821, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30.4545454545455, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48746; Mature: 48746

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTNRLSGVIKTLRGEARLTETNIQEALREVRMALLEADVALPVIKEFIARVKEKAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVIGSLTPGQALVGVVHQELIALMGGQKADINLATVPPAVILMAGLQGAGKTTSSGKL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCHHH
AKWLMEQKKKKVLLVSCDIYRPAAIQQLELLARQTGAEFFPVQAGQQPKEIAAAALNFAR
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHH
RHFHDVMIVDTAGRLAIDEAMMAEISELEALLKPIETLFVVDAMQGQDAVNTAKAFSEAL
HHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGVVLTKLDGDARGGAALSVLHVTGKPIKFAGVAEKLTGLEPFHPDRMASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHHHH
LGLIEEAQRGVDQQEAEKLAKKMKSGKSFDLNDFKMQFEQMRNMGGMGALMDKLPAQLSQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AAQNVKVDDKVIGRTEGIINSMTPQERLKPEILKASRKRRIAAGAGVTVQEVNRLLAQFE
HHHCCCCCHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QAQKMMKMMNKGGMTKMLRSMKGMLPGMR
HHHHHHHHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDNLTNRLSGVIKTLRGEARLTETNIQEALREVRMALLEADVALPVIKEFIARVKEKAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVIGSLTPGQALVGVVHQELIALMGGQKADINLATVPPAVILMAGLQGAGKTTSSGKL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCHHH
AKWLMEQKKKKVLLVSCDIYRPAAIQQLELLARQTGAEFFPVQAGQQPKEIAAAALNFAR
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHH
RHFHDVMIVDTAGRLAIDEAMMAEISELEALLKPIETLFVVDAMQGQDAVNTAKAFSEAL
HHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGVVLTKLDGDARGGAALSVLHVTGKPIKFAGVAEKLTGLEPFHPDRMASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHHHH
LGLIEEAQRGVDQQEAEKLAKKMKSGKSFDLNDFKMQFEQMRNMGGMGALMDKLPAQLSQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AAQNVKVDDKVIGRTEGIINSMTPQERLKPEILKASRKRRIAAGAGVTVQEVNRLLAQFE
HHHCCCCCHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QAQKMMKMMNKGGMTKMLRSMKGMLPGMR
HHHHHHHHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]