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The map label for this gene is lon [H]

Identifier: 82703216

GI number: 82703216

Start: 2388014

End: 2390386

Strand: Reverse

Name: lon [H]

Synonym: Nmul_A2097

Alternate gene names: 82703216

Gene position: 2390386-2388014 (Counterclockwise)

Preceding gene: 82703217

Following gene: 82703215

Centisome position: 75.07

GC content: 58.28

Gene sequence:

>2373_bases
ATGGGAGAGCTTATCGTAGCCAAGCCGGAATTACCTCAGGACGTGATTGCCCTCATACCCATGCGCAATATAGTGCTATT
CCCGCATGTTCTGACTGCAATCACCGTGGGTCGTGCCAAATCCATTGCTGCGCTGGAACATGCGCTCGATCCTAAAAGGC
CCCTAGGCATCATTCTGCAGAAAGATCCTGCTGTGGATGAGCCGGGGCAGGATGCGCTGTTTAATGTAGGTACCGTGGTG
AACGTTGTGCGGCATCTTGCCTCATCCGACGGGCTGCGGCATGCCGTGTGTCAGGGGTTGGGGCGCTTTTCCATCGAGGA
AATGATCGAGGATCGTCCTTTTCTCGCTGCCCGTGTGCGACTTATTGCGGAGCCTGATGAGGTATCGACGGAAGCTGAAG
CCCTGGCGATGCAATTGCGGGAGCGCACGGTGGAGATTCTTTCCCTGCTGCCCGGCGTACCGGCAGAACTGGCGCATGCG
CTACAAGCGACCCGCGCCCCTTCGCACCTGGCTGATATCGCGGCAAGCCTGCTCGATACCGAAGTTGCGGAGAAGCAGAT
GCTGCTTGAAACGGTCAGTACCGAGGAGCGGCTGCGAAAGGTGCTGCAGATTTTGTCGCGTCGTATCGAGGTACTGAGAT
TATCCCAGGAGATTGGTGAGCGTACGAAGGAGCATCTGGAAGACCGTGAACGCAAGTTTCTGTTGCGGGAGCAATTGAAG
ACGATCCAGAAAGAACTCGGCGAGACGGAGGGGGACGACCAGGAAATAGAGAAGCTGGATGAAGCGGTGGCCAAGGCTGG
CATGCCGGAAGAGATCGAGGCGCAGGCCAGAAAGGAATTGCAGCGCTTAAAGCGCATGCCTCCGGCTTCAAGCGAGTATT
CGATGCTGCATACCTACCTCGAATGGATGACAGAGTTGCCCTGGAAGCTCCCGGAAGATGCACCTATTGACCTCGATGCC
GCACGCCGAATTCTCGAACACGATCATTTCGGGCTGGAGCGCGTCAAACAGCGCATTATTGAATTCCTGGCCGTTCAGAA
GTTGAAGCCCCAAGGGCGTGCTCCTATCCTGTGTTTTGTCGGACCACCGGGGGTAGGCAAGACTTCGCTGGGCCAGAGCA
TAGCACGGGCATTGCAGCGGCCCTTCGTGCGCGTATCATTGGGTGGCGTGCATGACGAGGCGGAAATGCGAGGCCATCGT
CGCACCTACATTGGCGCCATGCCGGGTAACATTGTGCAGAGCCTGCGCAAGGCTGGCGCTCGAAACTGCGTGATGATGCT
CGATGAGGTGGATAAGATGTCAGCCAGCCTCCACGGCGACCCATCGGCAGCTCTGCTAGAGGTGCTGGATCCCGAGCAGA
ATTCTACGTTCCGGGACAATTACCTGGGGGTGCCCTTCGATTTGAGCCGTGTTGTTTTCATCGCCACCGCGAATGTTATT
GACAACGTGCCGCCTCCAGTGCGCGACCGGATGGAGATTATTGATCTCCCGGGCTACACCCGGGAGGAAAAGCTTCAGAT
CGCCCAGCGTTACCTCGTGGGGCGTCAACGCGAGGTAAACGGCCTCAGCGAGGATCAGTGCGAAATATCGGTGGAAGCGC
TCGATGGCATCATCGCCAATTACACCCGTGAGGCGGGAGTGCGGCAACTCGAACGGGAGATCGGGCGCGTCATGCGGCAT
GCAGCCATGCGTGTTGCGTCGGATGCAGAGGCTAAGGTACGCGTGGATGCCGCAGATCTGGATACTATCCTCGGCCCTGC
CAAATTCGAGCACGAGACCGGGCTGCTCACCAGTTTGCCAGGTGTTGCAACGGGACTTGCCTGGACACCCGTAGGCGGTG
ACATTCTTTTTATCGAGGCAACACGGGTGAGCGGACGTGGGCAGCTTATCCTAACCGGGCAGCTTGGCGGCGTGATGAAG
GAAAGTGCGCAGGCGGCGCTTACGTTGTTGAAAGGCCGGGCAGACAGTCTTCACATCCCCGCATCCGTATTTGAAGGCAT
CGACGTGCACGTGCATGTACCAGCAGGGGCTATTCCTAAAGATGGTCCCAGTGCAGGGGTGGCGATGTTCATAGCGCTTT
CTTCGCTCTTTACCAACCGCCCGGTACACCGGGATGTGGCGATGACGGGAGAGATCAGCCTGCGAGGGATGGTGCTGCCG
GTGGGAGGTATCAAGGAGAAGGTGCTTGCAGCCCAGCGGGCGGGCTTACGCGTGGTGCTGCTGCCCGCGCGCAACGAGAA
AGACCTGCGCGAGGTGCCGGAAACAACGCGTTCCACCTTGGAGTTCGTTTTTCTGGAAACAGTGGACGATGCGATTCAGG
CATCGCTGGGTCAGCGGGCGCGACGTCAGGAGTCGGAGTTCAAGCTTGTCTGA

Upstream 100 bases:

>100_bases
CGGTATTGCAGCCGGATCGCTAAAGCTATTGAGCGCATCCGAGTCGGAACTACACGGATTGCTCAGCCGATTCCTCGAAT
GTTTCTACAGAGAGACCGCC

Downstream 100 bases:

>100_bases
GCTGTAGTAGTTCAGATTTAATCTGACAGTAGGGCCTTGCGAAAAGCGGGGTTACCCGGTTTGATAGAGGTGCGAATCTT
TATCAAATTGAGCGCTGAAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MGELIVAKPELPQDVIALIPMRNIVLFPHVLTAITVGRAKSIAALEHALDPKRPLGIILQKDPAVDEPGQDALFNVGTVV
NVVRHLASSDGLRHAVCQGLGRFSIEEMIEDRPFLAARVRLIAEPDEVSTEAEALAMQLRERTVEILSLLPGVPAELAHA
LQATRAPSHLADIAASLLDTEVAEKQMLLETVSTEERLRKVLQILSRRIEVLRLSQEIGERTKEHLEDRERKFLLREQLK
TIQKELGETEGDDQEIEKLDEAVAKAGMPEEIEAQARKELQRLKRMPPASSEYSMLHTYLEWMTELPWKLPEDAPIDLDA
ARRILEHDHFGLERVKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGVHDEAEMRGHR
RTYIGAMPGNIVQSLRKAGARNCVMMLDEVDKMSASLHGDPSAALLEVLDPEQNSTFRDNYLGVPFDLSRVVFIATANVI
DNVPPPVRDRMEIIDLPGYTREEKLQIAQRYLVGRQREVNGLSEDQCEISVEALDGIIANYTREAGVRQLEREIGRVMRH
AAMRVASDAEAKVRVDAADLDTILGPAKFEHETGLLTSLPGVATGLAWTPVGGDILFIEATRVSGRGQLILTGQLGGVMK
ESAQAALTLLKGRADSLHIPASVFEGIDVHVHVPAGAIPKDGPSAGVAMFIALSSLFTNRPVHRDVAMTGEISLRGMVLP
VGGIKEKVLAAQRAGLRVVLLPARNEKDLREVPETTRSTLEFVFLETVDDAIQASLGQRARRQESEFKLV

Sequences:

>Translated_790_residues
MGELIVAKPELPQDVIALIPMRNIVLFPHVLTAITVGRAKSIAALEHALDPKRPLGIILQKDPAVDEPGQDALFNVGTVV
NVVRHLASSDGLRHAVCQGLGRFSIEEMIEDRPFLAARVRLIAEPDEVSTEAEALAMQLRERTVEILSLLPGVPAELAHA
LQATRAPSHLADIAASLLDTEVAEKQMLLETVSTEERLRKVLQILSRRIEVLRLSQEIGERTKEHLEDRERKFLLREQLK
TIQKELGETEGDDQEIEKLDEAVAKAGMPEEIEAQARKELQRLKRMPPASSEYSMLHTYLEWMTELPWKLPEDAPIDLDA
ARRILEHDHFGLERVKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGVHDEAEMRGHR
RTYIGAMPGNIVQSLRKAGARNCVMMLDEVDKMSASLHGDPSAALLEVLDPEQNSTFRDNYLGVPFDLSRVVFIATANVI
DNVPPPVRDRMEIIDLPGYTREEKLQIAQRYLVGRQREVNGLSEDQCEISVEALDGIIANYTREAGVRQLEREIGRVMRH
AAMRVASDAEAKVRVDAADLDTILGPAKFEHETGLLTSLPGVATGLAWTPVGGDILFIEATRVSGRGQLILTGQLGGVMK
ESAQAALTLLKGRADSLHIPASVFEGIDVHVHVPAGAIPKDGPSAGVAMFIALSSLFTNRPVHRDVAMTGEISLRGMVLP
VGGIKEKVLAAQRAGLRVVLLPARNEKDLREVPETTRSTLEFVFLETVDDAIQASLGQRARRQESEFKLV
>Mature_789_residues
GELIVAKPELPQDVIALIPMRNIVLFPHVLTAITVGRAKSIAALEHALDPKRPLGIILQKDPAVDEPGQDALFNVGTVVN
VVRHLASSDGLRHAVCQGLGRFSIEEMIEDRPFLAARVRLIAEPDEVSTEAEALAMQLRERTVEILSLLPGVPAELAHAL
QATRAPSHLADIAASLLDTEVAEKQMLLETVSTEERLRKVLQILSRRIEVLRLSQEIGERTKEHLEDRERKFLLREQLKT
IQKELGETEGDDQEIEKLDEAVAKAGMPEEIEAQARKELQRLKRMPPASSEYSMLHTYLEWMTELPWKLPEDAPIDLDAA
RRILEHDHFGLERVKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGVHDEAEMRGHRR
TYIGAMPGNIVQSLRKAGARNCVMMLDEVDKMSASLHGDPSAALLEVLDPEQNSTFRDNYLGVPFDLSRVVFIATANVID
NVPPPVRDRMEIIDLPGYTREEKLQIAQRYLVGRQREVNGLSEDQCEISVEALDGIIANYTREAGVRQLEREIGRVMRHA
AMRVASDAEAKVRVDAADLDTILGPAKFEHETGLLTSLPGVATGLAWTPVGGDILFIEATRVSGRGQLILTGQLGGVMKE
SAQAALTLLKGRADSLHIPASVFEGIDVHVHVPAGAIPKDGPSAGVAMFIALSSLFTNRPVHRDVAMTGEISLRGMVLPV
GGIKEKVLAAQRAGLRVVLLPARNEKDLREVPETTRSTLEFVFLETVDDAIQASLGQRARRQESEFKLV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=786, Percent_Identity=42.3664122137405, Blast_Score=583, Evalue=1e-166,
Organism=Homo sapiens, GI21396489, Length=701, Percent_Identity=42.3680456490728, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1786643, Length=762, Percent_Identity=44.750656167979, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=701, Percent_Identity=39.8002853067047, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=44.5672191528545, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319449, Length=667, Percent_Identity=37.6311844077961, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI221513036, Length=684, Percent_Identity=44.1520467836257, Blast_Score=547, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24666867, Length=684, Percent_Identity=44.1520467836257, Blast_Score=546, Evalue=1e-155,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87006; Mature: 86874

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELIVAKPELPQDVIALIPMRNIVLFPHVLTAITVGRAKSIAALEHALDPKRPLGIILQ
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
KDPAVDEPGQDALFNVGTVVNVVRHLASSDGLRHAVCQGLGRFSIEEMIEDRPFLAARVR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHH
LIAEPDEVSTEAEALAMQLRERTVEILSLLPGVPAELAHALQATRAPSHLADIAASLLDT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
EVAEKQMLLETVSTEERLRKVLQILSRRIEVLRLSQEIGERTKEHLEDRERKFLLREQLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIQKELGETEGDDQEIEKLDEAVAKAGMPEEIEAQARKELQRLKRMPPASSEYSMLHTYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EWMTELPWKLPEDAPIDLDAARRILEHDHFGLERVKQRIIEFLAVQKLKPQGRAPILCFV
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
GPPGVGKTSLGQSIARALQRPFVRVSLGGVHDEAEMRGHRRTYIGAMPGNIVQSLRKAGA
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCEEEECCCHHHHHHHHHCCC
RNCVMMLDEVDKMSASLHGDPSAALLEVLDPEQNSTFRDNYLGVPFDLSRVVFIATANVI
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEEEEHHHH
DNVPPPVRDRMEIIDLPGYTREEKLQIAQRYLVGRQREVNGLSEDQCEISVEALDGIIAN
CCCCCCHHHCHHEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHEEHHHHHHHHHH
YTREAGVRQLEREIGRVMRHAAMRVASDAEAKVRVDAADLDTILGPAKFEHETGLLTSLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCHHCCCCCCHHCCC
GVATGLAWTPVGGDILFIEATRVSGRGQLILTGQLGGVMKESAQAALTLLKGRADSLHIP
CHHHCCEECCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCC
ASVFEGIDVHVHVPAGAIPKDGPSAGVAMFIALSSLFTNRPVHRDVAMTGEISLRGMVLP
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEE
VGGIKEKVLAAQRAGLRVVLLPARNEKDLREVPETTRSTLEFVFLETVDDAIQASLGQRA
CCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRQESEFKLV
HHCCCCCCCC
>Mature Secondary Structure 
GELIVAKPELPQDVIALIPMRNIVLFPHVLTAITVGRAKSIAALEHALDPKRPLGIILQ
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
KDPAVDEPGQDALFNVGTVVNVVRHLASSDGLRHAVCQGLGRFSIEEMIEDRPFLAARVR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHH
LIAEPDEVSTEAEALAMQLRERTVEILSLLPGVPAELAHALQATRAPSHLADIAASLLDT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
EVAEKQMLLETVSTEERLRKVLQILSRRIEVLRLSQEIGERTKEHLEDRERKFLLREQLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIQKELGETEGDDQEIEKLDEAVAKAGMPEEIEAQARKELQRLKRMPPASSEYSMLHTYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EWMTELPWKLPEDAPIDLDAARRILEHDHFGLERVKQRIIEFLAVQKLKPQGRAPILCFV
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
GPPGVGKTSLGQSIARALQRPFVRVSLGGVHDEAEMRGHRRTYIGAMPGNIVQSLRKAGA
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCEEEECCCHHHHHHHHHCCC
RNCVMMLDEVDKMSASLHGDPSAALLEVLDPEQNSTFRDNYLGVPFDLSRVVFIATANVI
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEEEEHHHH
DNVPPPVRDRMEIIDLPGYTREEKLQIAQRYLVGRQREVNGLSEDQCEISVEALDGIIAN
CCCCCCHHHCHHEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHEEHHHHHHHHHH
YTREAGVRQLEREIGRVMRHAAMRVASDAEAKVRVDAADLDTILGPAKFEHETGLLTSLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCHHCCCCCCHHCCC
GVATGLAWTPVGGDILFIEATRVSGRGQLILTGQLGGVMKESAQAALTLLKGRADSLHIP
CHHHCCEECCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCC
ASVFEGIDVHVHVPAGAIPKDGPSAGVAMFIALSSLFTNRPVHRDVAMTGEISLRGMVLP
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEE
VGGIKEKVLAAQRAGLRVVLLPARNEKDLREVPETTRSTLEFVFLETVDDAIQASLGQRA
CCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRQESEFKLV
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA