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The map label for this gene is trxA [H]

Identifier: 82703204

GI number: 82703204

Start: 2377495

End: 2377818

Strand: Direct

Name: trxA [H]

Synonym: Nmul_A2084

Alternate gene names: 82703204

Gene position: 2377495-2377818 (Clockwise)

Preceding gene: 162139861

Following gene: 82703205

Centisome position: 74.66

GC content: 47.84

Gene sequence:

>324_bases
ATGAGTCATACCCACCATATTTCTGACGGAAATTTTGAGACTGAAGTATTGCAGTCGACAGTCCCTGTACTGGTTGACTA
TTGGGCAGAATGGTGTGGACCATGCAAGATGATAGCGCCCATCCTGGACGAGGTAGCCAAGGAATATGGCGACCGCCTCA
AGGTTGCCAAGCTCAATATCGACGAAAACCAGGCTACGCCCCCCAAATATGGTATTCGCGGTATCCCTACTCTCATGCTC
TTCAAAAACGGAAATATCGAAGCCACCAAAGTAGGGGCGTTATCGAAATCCCAGCTCACTGCTTTTATTGACAGTCACAT
CTAA

Upstream 100 bases:

>100_bases
TTCTGGTATCAATGGCAGGTGTCATTAATAGAGACCTGCCCTTGCAGAATTAACTGAATGTCAGTCGTACACATTTCATT
TAAGCGATTTGGAAAAGCAC

Downstream 100 bases:

>100_bases
AACTGCTAAGTTATAATTAACGCATTCCGCAAGCTCTCCGGTAGTTTCCGGTTCGATTACGTTCGCCGCTTCGAATTCTC
GTTCGGCTCCATCGGTTTTC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSHTHHISDGNFETEVLQSTVPVLVDYWAEWCGPCKMIAPILDEVAKEYGDRLKVAKLNIDENQATPPKYGIRGIPTLML
FKNGNIEATKVGALSKSQLTAFIDSHI

Sequences:

>Translated_107_residues
MSHTHHISDGNFETEVLQSTVPVLVDYWAEWCGPCKMIAPILDEVAKEYGDRLKVAKLNIDENQATPPKYGIRGIPTLML
FKNGNIEATKVGALSKSQLTAFIDSHI
>Mature_106_residues
SHTHHISDGNFETEVLQSTVPVLVDYWAEWCGPCKMIAPILDEVAKEYGDRLKVAKLNIDENQATPPKYGIRGIPTLMLF
KNGNIEATKVGALSKSQLTAFIDSHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=106, Percent_Identity=38.6792452830189, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=66.6666666666667, Blast_Score=154, Evalue=8e-40,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=35.4838709677419, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI87081747, Length=81, Percent_Identity=37.037037037037, Blast_Score=66, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=114, Percent_Identity=36.8421052631579, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=43.2098765432099, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=32.0388349514563, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=40.2985074626866, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=39.2405063291139, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=79, Percent_Identity=39.2405063291139, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=79, Percent_Identity=39.2405063291139, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=38.8888888888889, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=104, Percent_Identity=32.6923076923077, Blast_Score=67, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=42.8571428571429, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=34.4086021505376, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=39.1891891891892, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17648013, Length=62, Percent_Identity=41.9354838709677, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=62, Percent_Identity=41.9354838709677, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11869; Mature: 11738

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTHHISDGNFETEVLQSTVPVLVDYWAEWCGPCKMIAPILDEVAKEYGDRLKVAKLNI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DENQATPPKYGIRGIPTLMLFKNGNIEATKVGALSKSQLTAFIDSHI
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SHTHHISDGNFETEVLQSTVPVLVDYWAEWCGPCKMIAPILDEVAKEYGDRLKVAKLNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DENQATPPKYGIRGIPTLMLFKNGNIEATKVGALSKSQLTAFIDSHI
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]