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The map label for this gene is ldc [H]

Identifier: 82703085

GI number: 82703085

Start: 2258107

End: 2259282

Strand: Reverse

Name: ldc [H]

Synonym: Nmul_A1964

Alternate gene names: 82703085

Gene position: 2259282-2258107 (Counterclockwise)

Preceding gene: 82703086

Following gene: 82703082

Centisome position: 70.95

GC content: 55.44

Gene sequence:

>1176_bases
ATGCAAATGCGTAATACCGCTCTACGGCAACCCGTAGAAGTAGAAGAAATATTCGACACTCACCCCGAAGTCAGCCTGGA
TTTTGAACACGTTCAGGCAGCCCTCAAACAGGGCTACAGCAAGCCATTCCTGCTGGTTGACAGTAATATCATCCGCAACA
AGGCCCGAAGATTCAAAGCGGCCATGCCGCGCGTGCAGCCGCACTACGCGGTCAAGGCCAATCCTGATCCGCGCGTATTG
AAAACGCTGATCGAGGAAGGCGTTGGGTTTGAAATTGCCTCCATTTCAGAGCTTGACCTCCTGCTCAGCCTGAATGTGCC
TGCCGCGGATATTTATTACAGTAATCCGATGAAATCCCGGGCGTACCTGGAATATGCCGCAGCCAAAGGCGTGGAGTGGT
ATGTACTGGATAGTGTCGAGGAGCTACGCAAGATCGTCAGCGTGAAGCCGGATGCGAAACTGTATTTGCGGATCGATACG
CCCAACATCGGGAGCGACTGGCCGCTTGCCGGCAAGTTCGGCACGCATGTGGCCGAGATCAAGGAGATTATTGACGAAGC
CGCGAACCTTCAGGCTGATCTCGCCGGCGTGACCTTCCACGTCGGATCGCAATGCCGTAATCCGCAGAACTGGCGGGTGG
GCATCGAGCGGGCAATCAAGGTATTCGCCGACATGCGCCAGGCAGGATTGTCACCGCGTTTGCTCAATATCGGCGGCGGC
TATCCGGTGCGGCATGTCAAGCCCATTCCATCGATAGAAGTTATCGGTGAGGTCGTGAACGAAGCGATTGCGAACCTGCC
GGAGAACATTCGCATCATGGCTGAGCCCGGGCGCTACCTCGTCTCGGATGCGGCCTATTTTGTCTGCCGCGTAGTAGGAA
CGGCCACCCGCAACGGCAAACGCTGGATGTATTGGGATGCAGGCGTCTTTGGGGGCGTGATCGAGGTCACGGAGGGTTTA
CGGTATGAAATTCTTTCTGATCGCACGGGACCGAGCATTCCCTGGTCTGTAGCAGGGCCAACCTGTGATTCGGTCGATAT
TTTGATGCGCGATGAACTCCTGCCGGAGGATATCGAGGAAGGCGATTTCATCTATATACCCAATGCCGGCGCTTATACGA
CAGCCTACGCCAGTAACTTCAACGGCTTTCCTTTGCCAGAGGTCGTCGTCCTGTAA

Upstream 100 bases:

>100_bases
GAGGTCATCATGACAGGCAAAGCAAACTACTTCATCACGGCCGATCTGGTAAATATTCATACCCCCGTAACGTAGCGTCT
TCAAAAGGAAGGGCGATCTC

Downstream 100 bases:

>100_bases
GTCAATAAAATCAGGATTCCCGCTTGCCAGCCCGCTTCTCGACAAGCTGTTTCCGGGACGGTCAGGCAGCGCAATCGGAC
AATAATAATAAAAAAGGCGG

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQMRNTALRQPVEVEEIFDTHPEVSLDFEHVQAALKQGYSKPFLLVDSNIIRNKARRFKAAMPRVQPHYAVKANPDPRVL
KTLIEEGVGFEIASISELDLLLSLNVPAADIYYSNPMKSRAYLEYAAAKGVEWYVLDSVEELRKIVSVKPDAKLYLRIDT
PNIGSDWPLAGKFGTHVAEIKEIIDEAANLQADLAGVTFHVGSQCRNPQNWRVGIERAIKVFADMRQAGLSPRLLNIGGG
YPVRHVKPIPSIEVIGEVVNEAIANLPENIRIMAEPGRYLVSDAAYFVCRVVGTATRNGKRWMYWDAGVFGGVIEVTEGL
RYEILSDRTGPSIPWSVAGPTCDSVDILMRDELLPEDIEEGDFIYIPNAGAYTTAYASNFNGFPLPEVVVL

Sequences:

>Translated_391_residues
MQMRNTALRQPVEVEEIFDTHPEVSLDFEHVQAALKQGYSKPFLLVDSNIIRNKARRFKAAMPRVQPHYAVKANPDPRVL
KTLIEEGVGFEIASISELDLLLSLNVPAADIYYSNPMKSRAYLEYAAAKGVEWYVLDSVEELRKIVSVKPDAKLYLRIDT
PNIGSDWPLAGKFGTHVAEIKEIIDEAANLQADLAGVTFHVGSQCRNPQNWRVGIERAIKVFADMRQAGLSPRLLNIGGG
YPVRHVKPIPSIEVIGEVVNEAIANLPENIRIMAEPGRYLVSDAAYFVCRVVGTATRNGKRWMYWDAGVFGGVIEVTEGL
RYEILSDRTGPSIPWSVAGPTCDSVDILMRDELLPEDIEEGDFIYIPNAGAYTTAYASNFNGFPLPEVVVL
>Mature_391_residues
MQMRNTALRQPVEVEEIFDTHPEVSLDFEHVQAALKQGYSKPFLLVDSNIIRNKARRFKAAMPRVQPHYAVKANPDPRVL
KTLIEEGVGFEIASISELDLLLSLNVPAADIYYSNPMKSRAYLEYAAAKGVEWYVLDSVEELRKIVSVKPDAKLYLRIDT
PNIGSDWPLAGKFGTHVAEIKEIIDEAANLQADLAGVTFHVGSQCRNPQNWRVGIERAIKVFADMRQAGLSPRLLNIGGG
YPVRHVKPIPSIEVIGEVVNEAIANLPENIRIMAEPGRYLVSDAAYFVCRVVGTATRNGKRWMYWDAGVFGGVIEVTEGL
RYEILSDRTGPSIPWSVAGPTCDSVDILMRDELLPEDIEEGDFIYIPNAGAYTTAYASNFNGFPLPEVVVL

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=368, Percent_Identity=35.5978260869565, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI16506287, Length=366, Percent_Identity=31.6939890710383, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22538418, Length=378, Percent_Identity=29.6296296296296, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI21361583, Length=378, Percent_Identity=29.6296296296296, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1789203, Length=386, Percent_Identity=23.3160621761658, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789307, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=30.1075268817204, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25141365, Length=366, Percent_Identity=24.8633879781421, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25141367, Length=213, Percent_Identity=28.169014084507, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=374, Percent_Identity=31.283422459893, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24586474, Length=376, Percent_Identity=32.7127659574468, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24586472, Length=360, Percent_Identity=31.6666666666667, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43460; Mature: 43460

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMRNTALRQPVEVEEIFDTHPEVSLDFEHVQAALKQGYSKPFLLVDSNIIRNKARRFKA
CCCCCHHHCCCCCHHHHHCCCCCCEECHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHH
AMPRVQPHYAVKANPDPRVLKTLIEEGVGFEIASISELDLLLSLNVPAADIYYSNPMKSR
HCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEEEECCCCCHH
AYLEYAAAKGVEWYVLDSVEELRKIVSVKPDAKLYLRIDTPNIGSDWPLAGKFGTHVAEI
HHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHH
KEIIDEAANLQADLAGVTFHVGSQCRNPQNWRVGIERAIKVFADMRQAGLSPRLLNIGGG
HHHHHHHHCCCHHHCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
YPVRHVKPIPSIEVIGEVVNEAIANLPENIRIMAEPGRYLVSDAAYFVCRVVGTATRNGK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
RWMYWDAGVFGGVIEVTEGLRYEILSDRTGPSIPWSVAGPTCDSVDILMRDELLPEDIEE
EEEEECCCHHCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GDFIYIPNAGAYTTAYASNFNGFPLPEVVVL
CCEEEECCCCCEEEEECCCCCCCCCCCEEEC
>Mature Secondary Structure
MQMRNTALRQPVEVEEIFDTHPEVSLDFEHVQAALKQGYSKPFLLVDSNIIRNKARRFKA
CCCCCHHHCCCCCHHHHHCCCCCCEECHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHH
AMPRVQPHYAVKANPDPRVLKTLIEEGVGFEIASISELDLLLSLNVPAADIYYSNPMKSR
HCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEEEECCCCCHH
AYLEYAAAKGVEWYVLDSVEELRKIVSVKPDAKLYLRIDTPNIGSDWPLAGKFGTHVAEI
HHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHH
KEIIDEAANLQADLAGVTFHVGSQCRNPQNWRVGIERAIKVFADMRQAGLSPRLLNIGGG
HHHHHHHHCCCHHHCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
YPVRHVKPIPSIEVIGEVVNEAIANLPENIRIMAEPGRYLVSDAAYFVCRVVGTATRNGK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
RWMYWDAGVFGGVIEVTEGLRYEILSDRTGPSIPWSVAGPTCDSVDILMRDELLPEDIEE
EEEEECCCHHCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GDFIYIPNAGAYTTAYASNFNGFPLPEVVVL
CCEEEECCCCCEEEEECCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]