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The map label for this gene is pepA [H]

Identifier: 82703082

GI number: 82703082

Start: 2255027

End: 2256511

Strand: Reverse

Name: pepA [H]

Synonym: Nmul_A1961

Alternate gene names: 82703082

Gene position: 2256511-2255027 (Counterclockwise)

Preceding gene: 82703085

Following gene: 82703081

Centisome position: 70.86

GC content: 56.7

Gene sequence:

>1485_bases
ATGCTTGCAGCGCTCACGCAGAAAAATGCTCCCCTCGCCTCCCTTGACGACGCAGGCAAAGTCACTCATATCCTGGTGGT
ATTGCCCGCCCGGCCCGAACCATCGGGTGAGCTCGATTTTTTCGGAAAAGATTTGCTGAGCGTCCTGTTGTCGCGGCGCA
AAATGAAGGCGGAAGAAATCAGCGGAACGCCGGTTTCAGCCAATCTCCCGAGTGGCGAATTATGCGCGTGGGTGAGGGTC
GATCCGATCAAGTCCGTGTTCGAGCAGCAAGTATCGATGCGTAAAGCCTTGCAGTTGTTACTGGAAGAAAGCCCTTCCGA
AATAAGCGTTACCGTTTATGGCGACTCCGCCGAAAAGCGGATGGCGGCGCAACTGGCCCTCTACGCAGCATGGATCAATG
GTTCGTTACTGCCATCGCGCAAAACGGGCAAAAAGGAGGAGAACTGCCGCGGGCTCGAACGAATCGTGCTGCACGGGCAT
GAGGAAGCGGATAATTTTGCCCTGTTGAAGGCCATGGCGGAAGGAAATCTGCTTACGCGGGAGCTTACGGTGTTGCCACC
CAATGAGTTGACGCCGGGGCTCTACCGCAAGCGTATCCAGGAACTGGCAACAAGGGAAGGCTGGGACTATCAGGATTTCG
ATGTCAAAGCGCTGCGCGAGATGGGCGCCGGCGCTTTTGTCGCGGTTGCCCAGGGAAGCGATCCCGAAGACGCAGCCATA
GTGCATGTGCGGCGGCGAATGAAAAAAGTGGACAAGACAGCCGCCCTGGTGGGCAAGGGTATCTGCTTCGATACCGGAGG
GCATAACCTGAAGCCGGCACGTTACATGCATGGTATGCACGAGGACATGAATGGCTCCGCTGTTGCCCTGGGCATACTGT
TGGCTGCAACCCGCGCCAACCTCCCCGTGAATATCGATTGCTGGCTTGCCATCGCACAGAACCATATCAGCCCGCATGCC
TACAAGCAGAATGATGTCATCAGGACGCTCAATGGGACTACTGTAGAGATCGTCCATACGGATGCCGAAGGACGAATGGT
GCTCGCGGACACCCTGACGATGGCAGCGAGAGAGAAGCCCGATATTATGATGGATTTCGCAACGCTGACAGGAAGCATGC
ACGTGGCGCTGGGATCGCGCTACAGCGGCATTTTCAGCAATCGCGAAGAGTTGATGCAGAAGGCGTTGACAGCAGGGAGG
GTAACAGGCGAACGGGTCTGGGGATTTCCCCTCGATGCGGATTATGATGTTGAACTGGAAAGCAAGATTGCCGATGTGAG
GCAGTGCACCCTGGAGGGCGACGCCGATCATATTCTCGCCGCCAGATTTCTCAATCGCTTCGTGGATGACGTTCCCTGGC
TGCATATGGACCTTTCCGCGAGCAATCACAAGGAAGGACTGGGTGCGGTGGCAAGCCCGGTGACCGGGTTTGGTGTGGCG
TGGGGCGTGGAGATGCTCAGGGTCATGTTTTCAGGCTCCCTTTGA

Upstream 100 bases:

>100_bases
AGGTACTGGCGCATCGAAGTCGGTATTGTCGGGCTGCGGAATTTAGTAAAAGGAAACGCCCCGAGTATAATGGACATTCT
AACAGAATAAAGGTGATTCC

Downstream 100 bases:

>100_bases
CCTTTAACAGGAATAGTGGATATAGATCCTATCTTGTTCCCGCTTATCGAAATTGTTCGGATACATGCCCCTTTCTGATT
GAGCGGGTTTTGCAGGCCCA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MLAALTQKNAPLASLDDAGKVTHILVVLPARPEPSGELDFFGKDLLSVLLSRRKMKAEEISGTPVSANLPSGELCAWVRV
DPIKSVFEQQVSMRKALQLLLEESPSEISVTVYGDSAEKRMAAQLALYAAWINGSLLPSRKTGKKEENCRGLERIVLHGH
EEADNFALLKAMAEGNLLTRELTVLPPNELTPGLYRKRIQELATREGWDYQDFDVKALREMGAGAFVAVAQGSDPEDAAI
VHVRRRMKKVDKTAALVGKGICFDTGGHNLKPARYMHGMHEDMNGSAVALGILLAATRANLPVNIDCWLAIAQNHISPHA
YKQNDVIRTLNGTTVEIVHTDAEGRMVLADTLTMAAREKPDIMMDFATLTGSMHVALGSRYSGIFSNREELMQKALTAGR
VTGERVWGFPLDADYDVELESKIADVRQCTLEGDADHILAARFLNRFVDDVPWLHMDLSASNHKEGLGAVASPVTGFGVA
WGVEMLRVMFSGSL

Sequences:

>Translated_494_residues
MLAALTQKNAPLASLDDAGKVTHILVVLPARPEPSGELDFFGKDLLSVLLSRRKMKAEEISGTPVSANLPSGELCAWVRV
DPIKSVFEQQVSMRKALQLLLEESPSEISVTVYGDSAEKRMAAQLALYAAWINGSLLPSRKTGKKEENCRGLERIVLHGH
EEADNFALLKAMAEGNLLTRELTVLPPNELTPGLYRKRIQELATREGWDYQDFDVKALREMGAGAFVAVAQGSDPEDAAI
VHVRRRMKKVDKTAALVGKGICFDTGGHNLKPARYMHGMHEDMNGSAVALGILLAATRANLPVNIDCWLAIAQNHISPHA
YKQNDVIRTLNGTTVEIVHTDAEGRMVLADTLTMAAREKPDIMMDFATLTGSMHVALGSRYSGIFSNREELMQKALTAGR
VTGERVWGFPLDADYDVELESKIADVRQCTLEGDADHILAARFLNRFVDDVPWLHMDLSASNHKEGLGAVASPVTGFGVA
WGVEMLRVMFSGSL
>Mature_494_residues
MLAALTQKNAPLASLDDAGKVTHILVVLPARPEPSGELDFFGKDLLSVLLSRRKMKAEEISGTPVSANLPSGELCAWVRV
DPIKSVFEQQVSMRKALQLLLEESPSEISVTVYGDSAEKRMAAQLALYAAWINGSLLPSRKTGKKEENCRGLERIVLHGH
EEADNFALLKAMAEGNLLTRELTVLPPNELTPGLYRKRIQELATREGWDYQDFDVKALREMGAGAFVAVAQGSDPEDAAI
VHVRRRMKKVDKTAALVGKGICFDTGGHNLKPARYMHGMHEDMNGSAVALGILLAATRANLPVNIDCWLAIAQNHISPHA
YKQNDVIRTLNGTTVEIVHTDAEGRMVLADTLTMAAREKPDIMMDFATLTGSMHVALGSRYSGIFSNREELMQKALTAGR
VTGERVWGFPLDADYDVELESKIADVRQCTLEGDADHILAARFLNRFVDDVPWLHMDLSASNHKEGLGAVASPVTGFGVA
WGVEMLRVMFSGSL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=306, Percent_Identity=35.2941176470588, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI47155554, Length=331, Percent_Identity=29.607250755287, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1790710, Length=300, Percent_Identity=33, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082123, Length=308, Percent_Identity=34.7402597402597, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=30.5647840531561, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17565172, Length=141, Percent_Identity=38.2978723404255, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355725, Length=298, Percent_Identity=31.2080536912752, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24661038, Length=392, Percent_Identity=29.0816326530612, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221379063, Length=321, Percent_Identity=30.5295950155763, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI221379062, Length=321, Percent_Identity=30.5295950155763, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21357381, Length=321, Percent_Identity=30.5295950155763, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI161077148, Length=319, Percent_Identity=28.5266457680251, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI20130057, Length=319, Percent_Identity=28.5266457680251, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI20129969, Length=286, Percent_Identity=28.6713286713287, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24662227, Length=286, Percent_Identity=27.6223776223776, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355645, Length=307, Percent_Identity=26.3843648208469, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24662223, Length=307, Percent_Identity=26.3843648208469, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922386, Length=317, Percent_Identity=28.391167192429, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129963, Length=350, Percent_Identity=26.8571428571429, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646701, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646703, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358201, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54021; Mature: 54021

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAALTQKNAPLASLDDAGKVTHILVVLPARPEPSGELDFFGKDLLSVLLSRRKMKAEEI
CCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SGTPVSANLPSGELCAWVRVDPIKSVFEQQVSMRKALQLLLEESPSEISVTVYGDSAEKR
CCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
MAAQLALYAAWINGSLLPSRKTGKKEENCRGLERIVLHGHEEADNFALLKAMAEGNLLTR
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEE
ELTVLPPNELTPGLYRKRIQELATREGWDYQDFDVKALREMGAGAFVAVAQGSDPEDAAI
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHH
VHVRRRMKKVDKTAALVGKGICFDTGGHNLKPARYMHGMHEDMNGSAVALGILLAATRAN
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LPVNIDCWLAIAQNHISPHAYKQNDVIRTLNGTTVEIVHTDAEGRMVLADTLTMAAREKP
CCEEEHHHEEEHHCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEHHHHHHHCCCC
DIMMDFATLTGSMHVALGSRYSGIFSNREELMQKALTAGRVTGERVWGFPLDADYDVELE
CCEEEHHHHCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHH
SKIADVRQCTLEGDADHILAARFLNRFVDDVPWLHMDLSASNHKEGLGAVASPVTGFGVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCHHHHHH
WGVEMLRVMFSGSL
HHHHHHHHHHCCCC
>Mature Secondary Structure
MLAALTQKNAPLASLDDAGKVTHILVVLPARPEPSGELDFFGKDLLSVLLSRRKMKAEEI
CCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SGTPVSANLPSGELCAWVRVDPIKSVFEQQVSMRKALQLLLEESPSEISVTVYGDSAEKR
CCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
MAAQLALYAAWINGSLLPSRKTGKKEENCRGLERIVLHGHEEADNFALLKAMAEGNLLTR
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEE
ELTVLPPNELTPGLYRKRIQELATREGWDYQDFDVKALREMGAGAFVAVAQGSDPEDAAI
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHH
VHVRRRMKKVDKTAALVGKGICFDTGGHNLKPARYMHGMHEDMNGSAVALGILLAATRAN
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LPVNIDCWLAIAQNHISPHAYKQNDVIRTLNGTTVEIVHTDAEGRMVLADTLTMAAREKP
CCEEEHHHEEEHHCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEHHHHHHHCCCC
DIMMDFATLTGSMHVALGSRYSGIFSNREELMQKALTAGRVTGERVWGFPLDADYDVELE
CCEEEHHHHCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHH
SKIADVRQCTLEGDADHILAARFLNRFVDDVPWLHMDLSASNHKEGLGAVASPVTGFGVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCHHHHHH
WGVEMLRVMFSGSL
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA