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The map label for this gene is rnr [H]

Identifier: 82703074

GI number: 82703074

Start: 2242655

End: 2244862

Strand: Reverse

Name: rnr [H]

Synonym: Nmul_A1953

Alternate gene names: 82703074

Gene position: 2244862-2242655 (Counterclockwise)

Preceding gene: 82703079

Following gene: 82703073

Centisome position: 70.5

GC content: 53.53

Gene sequence:

>2208_bases
TTGACAATCAAGAAGAAACAAAAGCTCCGCAAGCTTGACCCTTATCTTGAACGGGAAAAAGAGCATTATGGGCATGCGCT
GCCTAGCCGGGAATTCATACTCCAGATACTCGAAGAGCAAGGCGTTCCCGTACCCGAGGAAGCATTGCAGAACCTGCTCG
GAATCACCGAAGAAGAAGGCGAGATCTTCAGCCGCCGTCTTTCTGCCATGTTGCGCGAAGGCCAGATCATGCGCAACCGG
AAGGGCGATATCTGCATGGTGGAGAAGCTCGCTCTTATCAAAGGCAAGGTTCAGGGTCACCCGGATGAATTTGGTTTTCT
GATACCTGACGATGGCAGTCCCGATTTGTTTTTGAGTGCCAAAGAAATGCGCAAGGCGCTGCATGGCGACCGCGTGATGG
TGCGTGAAATCGGGGTTGACCGGCGAGGCCGCCGGGAGGGAGCCATCGTAGAGGTGCTGGAGCGCGCAGTAACGCAGTTG
GTGGGACGATTACATGCGGATCACGGAATTCTTTACGTGGAGGCGGAGAATAGACGTATCAGCCAGGACATTCTGATTCC
CCGAGAAGAATCGATGAATGCAAGGGCAGGCCAGGTGGTCATCGTGGAAATCCTCCAGCAGCCGAGTAAACATGCCCAGC
CTATTGGGCGCATCATCGAGATTTTGGGCGACTACACGGCCCCCGGAATGGAGATCGAAATCGCGCTTCGCAAGCACGAC
TTGCCTTACCAGTTTCCACAGGAAGTGGAAAAACTTTCGGCACGTCTTCCATCCAAGGTGTTAAAAAAAGACCTGATCAA
GAGAGAAGACCTTCGTCACCTTCCGCTGGTGACGATAGACGGCGAAACTGCCCGGGATTTCGACGACGCCGTATATTGCG
AGCGTGACGGAAAGGATTACAAGCTTTATGTCGCCATCGCCGACGTCAGCCATTATGTAAAGCCGGGCGACGCTCTCGAT
CAGGAGGCATACAATCGTGGAAATTCCGTCTATTTTCCGCGGCGGGTTATCCCCATGCTGCCGGAAGCGCTATCGAACGG
GCTCTGTTCTCTCAACCCGGAGGTAGATCGCTTATCCATGGTGTGCGAAATAAGCCTGGATTTTGCAGGTGACTTCAAGG
GCTATCGTTTTTATCCCGCAGTCATGTTTTCTCACGCCCGGCTTACCTATACAAAAGTGGCGGCCATGCTGGAGAATTCT
AAGGGAGAGGAAGCGAAACAATATAAGGATCTCTTGCCGCACATCCAGTTGCTCTACAAATTATTCAAGGTATTGCTGAA
AGCGCGAAATCTGCGGGGGGCAATTGATTTTGAAACGATCGAAACGCGCATGATCTTCAACGATGAGGGCAAAATCGAGC
GCATCCTGCCGATACAACGTAACGACGCGCATCGCATCATCGAAGAATGCATGCTCGCCGCCAATGTATGTGCCTCCGAT
TTTCTGCAGAAACACAAGCAGGCGACTCTCTATCGGGTCCATGAAGGTCCGACGCCGGAAAAACTGGCCGCTCTGCGTGA
TTTTCTCAAGGAATTCGGTGTTCAGTTAGGTGGGGGGGATAACCCCAGGGCGAAAGATTACGCTCGTACGTTATCTACAA
TAAAGGATCGGCCCGATGCGCAGCTGTTGCAGACCGTGATGCTTCGATCCTTGCGCCAGGCAGTGTACAGTCCCGACAAC
GTTGGCCATTTCGGCCTGGCCTATGAATCCTATACACACTTTACATCCCCCATCAGGCGTTATCCCGATCTCCTCGTCCA
TCGAGCCATCAAGGCTGTCCTGAACAAGGCAGCATACTCTCCCGGCAACTGGCACGAACTGGGCGAGCATTGTTCGCAGA
CGGAGCGCCGCGCGGACGAGGCCACGCGCGATGTCGAAGCGTGGCTCAAGTGCTATTACATGCAGGACAGAATCGGAGAA
TGCTTTGAGGGAGTCGTCAGTGGGGTCGCCGGTTTTGGTCTTTTTGTGGCGCTGGACGGAATTTATGTCGAGGGACTCGT
GCATGTTTCAGAACTGCCCAGCGATTATTTCCATTTTGACGCGGTCAGGCATATGTTGCTGGGGGAGCGCACGGGGAAGC
GCTACCGCCTGGGTGACCGGCTCAGAGTCAGGCTGGTTCGAGTCGATCTGGAATCCAGCAAGATAGATTTCGTGCTCGCT
GAAAATGCCCAGGATGCGGGGAAAATAAAAACCGAGGCAGTGAGTTGA

Upstream 100 bases:

>100_bases
CTAGGACCTGAACCTAGTGCGTCTACCAATTCCGCCATCTGGGCAATGAGCGAATCTGTCCAACGATGGGACAGAGGCGC
AATTCTATAGGAAATCAGCT

Downstream 100 bases:

>100_bases
TTTCCGCGATGAATGTCCAGTCCCCGCTTATCATTTTCTGCAATTACTCGTTACTATAGATGTCCGGCTCACGTTTTATA
TTCGGTTTTCATGCAATTAC

Product: VacB/RNase II family 3'-5' exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MTIKKKQKLRKLDPYLEREKEHYGHALPSREFILQILEEQGVPVPEEALQNLLGITEEEGEIFSRRLSAMLREGQIMRNR
KGDICMVEKLALIKGKVQGHPDEFGFLIPDDGSPDLFLSAKEMRKALHGDRVMVREIGVDRRGRREGAIVEVLERAVTQL
VGRLHADHGILYVEAENRRISQDILIPREESMNARAGQVVIVEILQQPSKHAQPIGRIIEILGDYTAPGMEIEIALRKHD
LPYQFPQEVEKLSARLPSKVLKKDLIKREDLRHLPLVTIDGETARDFDDAVYCERDGKDYKLYVAIADVSHYVKPGDALD
QEAYNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCEISLDFAGDFKGYRFYPAVMFSHARLTYTKVAAMLENS
KGEEAKQYKDLLPHIQLLYKLFKVLLKARNLRGAIDFETIETRMIFNDEGKIERILPIQRNDAHRIIEECMLAANVCASD
FLQKHKQATLYRVHEGPTPEKLAALRDFLKEFGVQLGGGDNPRAKDYARTLSTIKDRPDAQLLQTVMLRSLRQAVYSPDN
VGHFGLAYESYTHFTSPIRRYPDLLVHRAIKAVLNKAAYSPGNWHELGEHCSQTERRADEATRDVEAWLKCYYMQDRIGE
CFEGVVSGVAGFGLFVALDGIYVEGLVHVSELPSDYFHFDAVRHMLLGERTGKRYRLGDRLRVRLVRVDLESSKIDFVLA
ENAQDAGKIKTEAVS

Sequences:

>Translated_735_residues
MTIKKKQKLRKLDPYLEREKEHYGHALPSREFILQILEEQGVPVPEEALQNLLGITEEEGEIFSRRLSAMLREGQIMRNR
KGDICMVEKLALIKGKVQGHPDEFGFLIPDDGSPDLFLSAKEMRKALHGDRVMVREIGVDRRGRREGAIVEVLERAVTQL
VGRLHADHGILYVEAENRRISQDILIPREESMNARAGQVVIVEILQQPSKHAQPIGRIIEILGDYTAPGMEIEIALRKHD
LPYQFPQEVEKLSARLPSKVLKKDLIKREDLRHLPLVTIDGETARDFDDAVYCERDGKDYKLYVAIADVSHYVKPGDALD
QEAYNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCEISLDFAGDFKGYRFYPAVMFSHARLTYTKVAAMLENS
KGEEAKQYKDLLPHIQLLYKLFKVLLKARNLRGAIDFETIETRMIFNDEGKIERILPIQRNDAHRIIEECMLAANVCASD
FLQKHKQATLYRVHEGPTPEKLAALRDFLKEFGVQLGGGDNPRAKDYARTLSTIKDRPDAQLLQTVMLRSLRQAVYSPDN
VGHFGLAYESYTHFTSPIRRYPDLLVHRAIKAVLNKAAYSPGNWHELGEHCSQTERRADEATRDVEAWLKCYYMQDRIGE
CFEGVVSGVAGFGLFVALDGIYVEGLVHVSELPSDYFHFDAVRHMLLGERTGKRYRLGDRLRVRLVRVDLESSKIDFVLA
ENAQDAGKIKTEAVS
>Mature_734_residues
TIKKKQKLRKLDPYLEREKEHYGHALPSREFILQILEEQGVPVPEEALQNLLGITEEEGEIFSRRLSAMLREGQIMRNRK
GDICMVEKLALIKGKVQGHPDEFGFLIPDDGSPDLFLSAKEMRKALHGDRVMVREIGVDRRGRREGAIVEVLERAVTQLV
GRLHADHGILYVEAENRRISQDILIPREESMNARAGQVVIVEILQQPSKHAQPIGRIIEILGDYTAPGMEIEIALRKHDL
PYQFPQEVEKLSARLPSKVLKKDLIKREDLRHLPLVTIDGETARDFDDAVYCERDGKDYKLYVAIADVSHYVKPGDALDQ
EAYNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCEISLDFAGDFKGYRFYPAVMFSHARLTYTKVAAMLENSK
GEEAKQYKDLLPHIQLLYKLFKVLLKARNLRGAIDFETIETRMIFNDEGKIERILPIQRNDAHRIIEECMLAANVCASDF
LQKHKQATLYRVHEGPTPEKLAALRDFLKEFGVQLGGGDNPRAKDYARTLSTIKDRPDAQLLQTVMLRSLRQAVYSPDNV
GHFGLAYESYTHFTSPIRRYPDLLVHRAIKAVLNKAAYSPGNWHELGEHCSQTERRADEATRDVEAWLKCYYMQDRIGEC
FEGVVSGVAGFGLFVALDGIYVEGLVHVSELPSDYFHFDAVRHMLLGERTGKRYRLGDRLRVRLVRVDLESSKIDFVLAE
NAQDAGKIKTEAVS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=487, Percent_Identity=31.4168377823409, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI190014623, Length=487, Percent_Identity=31.4168377823409, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI19115966, Length=515, Percent_Identity=27.378640776699, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI219521928, Length=515, Percent_Identity=27.378640776699, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI134288890, Length=429, Percent_Identity=29.3706293706294, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI156105695, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI156105693, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI87082383, Length=722, Percent_Identity=51.3850415512465, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=643, Percent_Identity=26.7496111975117, Blast_Score=188, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI212645896, Length=511, Percent_Identity=30.7240704500978, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17553506, Length=581, Percent_Identity=27.8829604130809, Blast_Score=166, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=604, Percent_Identity=27.8145695364238, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320499, Length=554, Percent_Identity=21.841155234657, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24649634, Length=479, Percent_Identity=30.2713987473904, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI19922976, Length=429, Percent_Identity=27.5058275058275, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24654597, Length=429, Percent_Identity=27.5058275058275, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24654592, Length=429, Percent_Identity=27.5058275058275, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 83717; Mature: 83586

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKKKQKLRKLDPYLEREKEHYGHALPSREFILQILEEQGVPVPEEALQNLLGITEEEG
CCCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHH
EIFSRRLSAMLREGQIMRNRKGDICMVEKLALIKGKVQGHPDEFGFLIPDDGSPDLFLSA
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEH
KEMRKALHGDRVMVREIGVDRRGRREGAIVEVLERAVTQLVGRLHADHGILYVEAENRRI
HHHHHHHCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SQDILIPREESMNARAGQVVIVEILQQPSKHAQPIGRIIEILGDYTAPGMEIEIALRKHD
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
LPYQFPQEVEKLSARLPSKVLKKDLIKREDLRHLPLVTIDGETARDFDDAVYCERDGKDY
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCE
KLYVAIADVSHYVKPGDALDQEAYNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSM
EEEEEEECHHHHCCCCCHHCHHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCCCHHHHHE
VCEISLDFAGDFKGYRFYPAVMFSHARLTYTKVAAMLENSKGEEAKQYKDLLPHIQLLYK
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LFKVLLKARNLRGAIDFETIETRMIFNDEGKIERILPIQRNDAHRIIEECMLAANVCASD
HHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FLQKHKQATLYRVHEGPTPEKLAALRDFLKEFGVQLGGGDNPRAKDYARTLSTIKDRPDA
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHCCCHH
QLLQTVMLRSLRQAVYSPDNVGHFGLAYESYTHFTSPIRRYPDLLVHRAIKAVLNKAAYS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGNWHELGEHCSQTERRADEATRDVEAWLKCYYMQDRIGECFEGVVSGVAGFGLFVALDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYVEGLVHVSELPSDYFHFDAVRHMLLGERTGKRYRLGDRLRVRLVRVDLESSKIDFVLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEEEECCCCCEEEEEE
ENAQDAGKIKTEAVS
CCCCCCCCCHHHCCC
>Mature Secondary Structure 
TIKKKQKLRKLDPYLEREKEHYGHALPSREFILQILEEQGVPVPEEALQNLLGITEEEG
CCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHH
EIFSRRLSAMLREGQIMRNRKGDICMVEKLALIKGKVQGHPDEFGFLIPDDGSPDLFLSA
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEH
KEMRKALHGDRVMVREIGVDRRGRREGAIVEVLERAVTQLVGRLHADHGILYVEAENRRI
HHHHHHHCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SQDILIPREESMNARAGQVVIVEILQQPSKHAQPIGRIIEILGDYTAPGMEIEIALRKHD
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
LPYQFPQEVEKLSARLPSKVLKKDLIKREDLRHLPLVTIDGETARDFDDAVYCERDGKDY
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCE
KLYVAIADVSHYVKPGDALDQEAYNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSM
EEEEEEECHHHHCCCCCHHCHHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCCCHHHHHE
VCEISLDFAGDFKGYRFYPAVMFSHARLTYTKVAAMLENSKGEEAKQYKDLLPHIQLLYK
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LFKVLLKARNLRGAIDFETIETRMIFNDEGKIERILPIQRNDAHRIIEECMLAANVCASD
HHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FLQKHKQATLYRVHEGPTPEKLAALRDFLKEFGVQLGGGDNPRAKDYARTLSTIKDRPDA
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHCCCHH
QLLQTVMLRSLRQAVYSPDNVGHFGLAYESYTHFTSPIRRYPDLLVHRAIKAVLNKAAYS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGNWHELGEHCSQTERRADEATRDVEAWLKCYYMQDRIGECFEGVVSGVAGFGLFVALDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYVEGLVHVSELPSDYFHFDAVRHMLLGERTGKRYRLGDRLRVRLVRVDLESSKIDFVLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEEEECCCCCEEEEEE
ENAQDAGKIKTEAVS
CCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]