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The map label for this gene is dapL [H]

Identifier: 82702971

GI number: 82702971

Start: 2133663

End: 2134856

Strand: Direct

Name: dapL [H]

Synonym: Nmul_A1850

Alternate gene names: 82702971

Gene position: 2133663-2134856 (Clockwise)

Preceding gene: 82702964

Following gene: 82702972

Centisome position: 67.01

GC content: 55.28

Gene sequence:

>1194_bases
TTGAATCCCAATCTGAACCGCCTGCAACCATACCCTTTTGAGAAACTCACCAAGCTATTTGAAGGAATCGAGCCTGCATC
GGCTTTTACGCCTATCAGTCTCCACATCGGAGAGCCCAAGCATTCGACTCCGGATTTCATTCGCCAGGCCTTGATGGAAA
ATCTGGTGAAGATGGCGCACTATCCGGCAACCCTCGGCGCACGCTCCCTGCGCGCCAGCATCGGCAAATGGCTGATGCAG
CGCTACGGCCTGCCGGCAATCGACCCCGATACGGAAATCCTGCCGGTCAATGGCAGCCGCGAAGCCTTGTTTTCTTTTGC
GCAGGCAGTGATCGATTCTTCCAAGCCCGGTGCAATTGTAATTTGTCCGAACCCGTTTTATCAGATATACGAAGGCGCTG
CATTGCTTGCGGGCGCAACGCCCAGTTTCCTCAATACCCTGCCAGAGAATGATTTTTCGCTCGACTATGCTCAATTACCG
GATGAAGTATGGTCGCGCACGCAGCTTGTGTATGTCTGTTCGCCCGGGAATCCCACCGGCCGCGTAATGTCGATGGACGA
ATGGCGCCATCTGTTCGAACTTTCGGACCGTTATGGATTTGTCATTGCATCGGACGAATGTTACTCTGAAATCTATTTTG
ATGAAGCTTCTCCTCCATTGGGCGCGCTCCAGGCCGCCCACCGCTTGGGCCGGGAGGGCTTCTCCCGGCTGGTGGTATTC
AGCAGCCTTTCCAAAAGATCGAATGTTCCCGGCATGCGTTCCGGATTCGTTGCCGGAGATGCGGCGATCCTGAAAAAATT
CCTGCTCTACCGCACCTATCATGGCAGCGCGATGAACCCGGCGGTACAGGCGGCCAGCGAAGAGGCCTGGAATGATGAGG
TTCATGTTGTCGAAAACCGCCGCCTCTACCGGGAGAAATTCAAGGCAGTCATCAAATTACTACAGGGCGCGCTGTCGGTT
TCGCTGCCGGACGCGGCTTTCTACCTGTGGTTGAAGGTCCCGGTGAATGACGTCGAGTTCGCCCGGCAGCTCTATCGCGA
TTATAATGTCACGGTTTTGCCCGGCAGCTACCTCGCACGGCATGCGCACGGGATTAACCCCGGCGAAAATTTTGTCCGCA
TTGCCCTGGTGGCATCCGTAATGGAATGCGCCGCCGCTACCGAACGGATAAAGAAGCTGGTATCCAGATTGTAG

Upstream 100 bases:

>100_bases
TATTGTTTATTTTGCTTTGTGAGCAAGAGAGTGCCCTCTTATAATCCTGCTTCGATCAATAACTCAACGGGGAATAGAGC
TTTCTTCCCATCGCCTTAAA

Downstream 100 bases:

>100_bases
CGGGTAGCCTGGAGCAGCGATATATCAACAAGAAATCAAAGGAAGATCATGGATCAGCTCCAAAGTACGATTGAAGAAGC
GTTTGAACGCCGCGCCGAGA

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNPNLNRLQPYPFEKLTKLFEGIEPASAFTPISLHIGEPKHSTPDFIRQALMENLVKMAHYPATLGARSLRASIGKWLMQ
RYGLPAIDPDTEILPVNGSREALFSFAQAVIDSSKPGAIVICPNPFYQIYEGAALLAGATPSFLNTLPENDFSLDYAQLP
DEVWSRTQLVYVCSPGNPTGRVMSMDEWRHLFELSDRYGFVIASDECYSEIYFDEASPPLGALQAAHRLGREGFSRLVVF
SSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASEEAWNDEVHVVENRRLYREKFKAVIKLLQGALSV
SLPDAAFYLWLKVPVNDVEFARQLYRDYNVTVLPGSYLARHAHGINPGENFVRIALVASVMECAAATERIKKLVSRL

Sequences:

>Translated_397_residues
MNPNLNRLQPYPFEKLTKLFEGIEPASAFTPISLHIGEPKHSTPDFIRQALMENLVKMAHYPATLGARSLRASIGKWLMQ
RYGLPAIDPDTEILPVNGSREALFSFAQAVIDSSKPGAIVICPNPFYQIYEGAALLAGATPSFLNTLPENDFSLDYAQLP
DEVWSRTQLVYVCSPGNPTGRVMSMDEWRHLFELSDRYGFVIASDECYSEIYFDEASPPLGALQAAHRLGREGFSRLVVF
SSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASEEAWNDEVHVVENRRLYREKFKAVIKLLQGALSV
SLPDAAFYLWLKVPVNDVEFARQLYRDYNVTVLPGSYLARHAHGINPGENFVRIALVASVMECAAATERIKKLVSRL
>Mature_397_residues
MNPNLNRLQPYPFEKLTKLFEGIEPASAFTPISLHIGEPKHSTPDFIRQALMENLVKMAHYPATLGARSLRASIGKWLMQ
RYGLPAIDPDTEILPVNGSREALFSFAQAVIDSSKPGAIVICPNPFYQIYEGAALLAGATPSFLNTLPENDFSLDYAQLP
DEVWSRTQLVYVCSPGNPTGRVMSMDEWRHLFELSDRYGFVIASDECYSEIYFDEASPPLGALQAAHRLGREGFSRLVVF
SSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASEEAWNDEVHVVENRRLYREKFKAVIKLLQGALSV
SLPDAAFYLWLKVPVNDVEFARQLYRDYNVTVLPGSYLARHAHGINPGENFVRIALVASVMECAAATERIKKLVSRL

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=394, Percent_Identity=23.6040609137056, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI56713254, Length=393, Percent_Identity=23.6641221374046, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI95147551, Length=412, Percent_Identity=23.5436893203883, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI169881279, Length=412, Percent_Identity=23.5436893203883, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4507369, Length=409, Percent_Identity=22.4938875305623, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788722, Length=403, Percent_Identity=25.8064516129032, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786816, Length=372, Percent_Identity=25.5376344086022, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790797, Length=369, Percent_Identity=24.390243902439, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788627, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=401, Percent_Identity=25.6857855361596, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=401, Percent_Identity=25.6857855361596, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=399, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573069, Length=410, Percent_Identity=21.7073170731707, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646114, Length=410, Percent_Identity=21.7073170731707, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573067, Length=410, Percent_Identity=21.7073170731707, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573065, Length=410, Percent_Identity=21.7073170731707, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859735, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44251; Mature: 44251

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNLNRLQPYPFEKLTKLFEGIEPASAFTPISLHIGEPKHSTPDFIRQALMENLVKMAH
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
YPATLGARSLRASIGKWLMQRYGLPAIDPDTEILPVNGSREALFSFAQAVIDSSKPGAIV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEE
ICPNPFYQIYEGAALLAGATPSFLNTLPENDFSLDYAQLPDEVWSRTQLVYVCSPGNPTG
ECCCHHHHHHCCCCEECCCCHHHHHHCCCCCCCCCHHHCCHHHHCCEEEEEEECCCCCCC
RVMSMDEWRHLFELSDRYGFVIASDECYSEIYFDEASPPLGALQAAHRLGREGFSRLVVF
CEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASEEAWNDEVHVVENR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEHHH
RLYREKFKAVIKLLQGALSVSLPDAAFYLWLKVPVNDVEFARQLYRDYNVTVLPGSYLAR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECHHHHHH
HAHGINPGENFVRIALVASVMECAAATERIKKLVSRL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPNLNRLQPYPFEKLTKLFEGIEPASAFTPISLHIGEPKHSTPDFIRQALMENLVKMAH
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
YPATLGARSLRASIGKWLMQRYGLPAIDPDTEILPVNGSREALFSFAQAVIDSSKPGAIV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEE
ICPNPFYQIYEGAALLAGATPSFLNTLPENDFSLDYAQLPDEVWSRTQLVYVCSPGNPTG
ECCCHHHHHHCCCCEECCCCHHHHHHCCCCCCCCCHHHCCHHHHCCEEEEEEECCCCCCC
RVMSMDEWRHLFELSDRYGFVIASDECYSEIYFDEASPPLGALQAAHRLGREGFSRLVVF
CEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASEEAWNDEVHVVENR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEHHH
RLYREKFKAVIKLLQGALSVSLPDAAFYLWLKVPVNDVEFARQLYRDYNVTVLPGSYLAR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECHHHHHH
HAHGINPGENFVRIALVASVMECAAATERIKKLVSRL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA