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The map label for this gene is czcD [H]

Identifier: 82702867

GI number: 82702867

Start: 1997469

End: 1998428

Strand: Reverse

Name: czcD [H]

Synonym: Nmul_A1744

Alternate gene names: 82702867

Gene position: 1998428-1997469 (Counterclockwise)

Preceding gene: 82702881

Following gene: 82702866

Centisome position: 62.76

GC content: 56.15

Gene sequence:

>960_bases
ATGGCAAATCATCACAGTCGCGGCCCCGGTTTTTCCAACATGCCATCTCATACCAGGCACCCTGGATACCATAACCATTC
TCCCGCACCCGATCACGGACGTGCGTTCGTTATTGCTATCGCCTTAAATGCCGGCTTTGTCGTGGTTGAATTCGCTTACG
GCTTTGCCGCCAACTCGACGGCACTCATGGCGGATGCTGGGCATAATTTGTCGGATGTGCTCGGGCTTGCGTTAGCCTGG
GGAGCGGCGATTTTGAGCCGCAAGGCTCCGAGCGAACGTTATACCTATGGTTTGCGCAGCACTTCGATACTCGCCGCGCT
GGCAAATGCTGTTCTGCTTCTGGTGGCGTGCGGGGCAATCGCCTGGGAAGCTTTTCAGCGGTTTTCACAACCGCCGCTGG
TAGCGGGCCTCACCGTTGCTTCCGTCGCAGCCGCTGGTCTTCTGATCAACGGTCTGTCTGCCTGGTTGTTTTTGAAGGGG
AGCAAAGAGGACCTGAATATTCATGGCGCTTTCCTGCACATGGCGACAGATGCCGCTGTTTCGGCAGGCGTGCTCGTATC
GGGGGTGGCGATCCTTTTTACGCAATGGTATTGGCTCGACCCGGTGATCAGCCTGATGGTCGTTACCGTCATTATGTTCA
ATACATGGGGTCTTCTGCGCGACTCGGTTCAGCTTGCGCTCAGCGCCGTGCCCCCGCATATCGATATTGCCGCGATCGAA
TCTTTTCTGCGTAACCAGCCGGGTGTGACGGACGTACATGACCTGCATATATGGGGTTTGAGTACGACCGAGAGCGCCCT
CACTGTCCACCTCGTCATGCCGGACGGCTACCCGGGGGATGCATTCATGGACAATATCAGGAACAACCTTGAATCGCACT
ATGCGATCCACCACAGTACCCTGGAGATCGAACAGGGAACCATCAGTCATTATTGCCCGGTGTCGACGGAGTCCGATTGA

Upstream 100 bases:

>100_bases
AATTCAGAGCCGGGAAAGAGGGGGAATGGGGGAGCAGGAATAGGGGTGGATTGTTGCTATCATTGTTCGGCTTACGCGTC
TTCCATTCAGATTGAGGCAA

Downstream 100 bases:

>100_bases
TCTTCGTTGATTGGAGTTGGAATCGCGAGTGCCCACGGAAAGAATGAAGTGAGGCGAAAGATCAACCTCTGACCTATCGA
CTTTGCTGGCGTAAAAGCAT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MANHHSRGPGFSNMPSHTRHPGYHNHSPAPDHGRAFVIAIALNAGFVVVEFAYGFAANSTALMADAGHNLSDVLGLALAW
GAAILSRKAPSERYTYGLRSTSILAALANAVLLLVACGAIAWEAFQRFSQPPLVAGLTVASVAAAGLLINGLSAWLFLKG
SKEDLNIHGAFLHMATDAAVSAGVLVSGVAILFTQWYWLDPVISLMVVTVIMFNTWGLLRDSVQLALSAVPPHIDIAAIE
SFLRNQPGVTDVHDLHIWGLSTTESALTVHLVMPDGYPGDAFMDNIRNNLESHYAIHHSTLEIEQGTISHYCPVSTESD

Sequences:

>Translated_319_residues
MANHHSRGPGFSNMPSHTRHPGYHNHSPAPDHGRAFVIAIALNAGFVVVEFAYGFAANSTALMADAGHNLSDVLGLALAW
GAAILSRKAPSERYTYGLRSTSILAALANAVLLLVACGAIAWEAFQRFSQPPLVAGLTVASVAAAGLLINGLSAWLFLKG
SKEDLNIHGAFLHMATDAAVSAGVLVSGVAILFTQWYWLDPVISLMVVTVIMFNTWGLLRDSVQLALSAVPPHIDIAAIE
SFLRNQPGVTDVHDLHIWGLSTTESALTVHLVMPDGYPGDAFMDNIRNNLESHYAIHHSTLEIEQGTISHYCPVSTESD
>Mature_318_residues
ANHHSRGPGFSNMPSHTRHPGYHNHSPAPDHGRAFVIAIALNAGFVVVEFAYGFAANSTALMADAGHNLSDVLGLALAWG
AAILSRKAPSERYTYGLRSTSILAALANAVLLLVACGAIAWEAFQRFSQPPLVAGLTVASVAAAGLLINGLSAWLFLKGS
KEDLNIHGAFLHMATDAAVSAGVLVSGVAILFTQWYWLDPVISLMVVTVIMFNTWGLLRDSVQLALSAVPPHIDIAAIES
FLRNQPGVTDVHDLHIWGLSTTESALTVHLVMPDGYPGDAFMDNIRNNLESHYAIHHSTLEIEQGTISHYCPVSTESD

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=312, Percent_Identity=24.6794871794872, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI21359890, Length=268, Percent_Identity=28.3582089552239, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803013, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI289803009, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI289803007, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI289803003, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI64762489, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI21361112, Length=321, Percent_Identity=26.791277258567, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI14210520, Length=221, Percent_Identity=24.8868778280543, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI52351208, Length=161, Percent_Identity=26.7080745341615, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI52352803, Length=181, Percent_Identity=25.9668508287293, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786966, Length=279, Percent_Identity=37.2759856630824, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=27.2151898734177, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=27.6872964169381, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17555796, Length=286, Percent_Identity=28.3216783216783, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=26.4026402640264, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324892, Length=124, Percent_Identity=36.2903225806452, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=131, Percent_Identity=34.3511450381679, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=33.5227272727273, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583858, Length=312, Percent_Identity=22.7564102564103, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=24.8275862068966, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584409, Length=145, Percent_Identity=24.8275862068966, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656728, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656724, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656720, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656715, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357035, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34104; Mature: 33973

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHHSRGPGFSNMPSHTRHPGYHNHSPAPDHGRAFVIAIALNAGFVVVEFAYGFAANST
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCC
ALMADAGHNLSDVLGLALAWGAAILSRKAPSERYTYGLRSTSILAALANAVLLLVACGAI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHH
AWEAFQRFSQPPLVAGLTVASVAAAGLLINGLSAWLFLKGSKEDLNIHGAFLHMATDAAV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEEHHHHHHH
SAGVLVSGVAILFTQWYWLDPVISLMVVTVIMFNTWGLLRDSVQLALSAVPPHIDIAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFLRNQPGVTDVHDLHIWGLSTTESALTVHLVMPDGYPGDAFMDNIRNNLESHYAIHHST
HHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEE
LEIEQGTISHYCPVSTESD
EEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANHHSRGPGFSNMPSHTRHPGYHNHSPAPDHGRAFVIAIALNAGFVVVEFAYGFAANST
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCC
ALMADAGHNLSDVLGLALAWGAAILSRKAPSERYTYGLRSTSILAALANAVLLLVACGAI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHH
AWEAFQRFSQPPLVAGLTVASVAAAGLLINGLSAWLFLKGSKEDLNIHGAFLHMATDAAV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEEHHHHHHH
SAGVLVSGVAILFTQWYWLDPVISLMVVTVIMFNTWGLLRDSVQLALSAVPPHIDIAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFLRNQPGVTDVHDLHIWGLSTTESALTVHLVMPDGYPGDAFMDNIRNNLESHYAIHHST
HHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEE
LEIEQGTISHYCPVSTESD
EEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]