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The map label for this gene is pyrF

Identifier: 78779810

GI number: 78779810

Start: 1339129

End: 1339857

Strand: Reverse

Name: pyrF

Synonym: PMT9312_1426

Alternate gene names: 78779810

Gene position: 1339857-1339129 (Counterclockwise)

Preceding gene: 78779811

Following gene: 78779803

Centisome position: 78.39

GC content: 30.32

Gene sequence:

>729_bases
ATGAAAAATAGATTTAATTCAGAAGATAAAATAATATTGGCAATTGATGGACTAGATCTAAATCAAGCAAAATTACTTCT
AGAAAAATGTCCTAGTATTAAGTGGGTGAAAGTTGGTTTAGAGCTTTTTGTGAGGGAAGGCCCAAGAGTTGTTGAAATAT
TAAAAGGTTTAAATAAAAAAATTTTTTTAGACTTAAAATTTCATGATATTCCAAATACCATGAGCGCAGCTTGTTTCCAA
GTGTCAAAATTAGGGGTTGATATAATTTCTGTACATTCTTCAGCAGGTCTTAAAGCTCTTCAGGATTCAAAAAAAGCATC
TTTAGAAGGAGCAAGTTTGGCCAATTTAAAACCTCCTTTTGTTGTAGGTATAACTGTCTTAACAAGTTTTTCTCTTAAAG
ATTTTCAAACTGATCTTGATCGGAAAAATTCAATTGAAGATAATGTATTGAGGCTTGCAAAGTTGTCTTTTGATGCAGAA
TTAGATGGATGTGTTTGTTCCCCTTGGGAAGTAAAAATGTTGAGATCGATTTATAAGAACAATTTTGAACTAATAACACC
TGGTATTAGATTAAAGATTGATAATAAAGATGATCAAAATAGAATTATGACTCCTAATGAAGCCATAGATAATGGTGCTT
CTAAATTGGTCATTGGTAGATCAATATCAAAAGCTTTAGACCCTAATAAAGCTCTGATAGAGATTTTTAAATCTATTGAT
TCTGATTAA

Upstream 100 bases:

>100_bases
AATAAATCCCGATATAGTTTTTGACTCAAAAAAAGATTTAGAAGGTAAAATTTTACAAATTGGAAAAAAAATCATTAAGA
GGTTTGAAAACTAAAAATAA

Downstream 100 bases:

>100_bases
TTTTGGATTCTTCTCCTTTTAGCAATCTTGTTATGTTTGTTCTATGTTTCCAGATAACTAATAGTGCCACAATTAAACTT
ATAAAAAAGTATGAGTGCAT

Product: orotidine-5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKKIFLDLKFHDIPNTMSAACFQ
VSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPFVVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAE
LDGCVCSPWEVKMLRSIYKNNFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSID
SD

Sequences:

>Translated_242_residues
MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKKIFLDLKFHDIPNTMSAACFQ
VSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPFVVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAE
LDGCVCSPWEVKMLRSIYKNNFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSID
SD
>Mature_242_residues
MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKKIFLDLKFHDIPNTMSAACFQ
VSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPFVVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAE
LDGCVCSPWEVKMLRSIYKNNFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSID
SD

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787537, Length=238, Percent_Identity=35.7142857142857, Blast_Score=141, Evalue=4e-35,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PYRF_PROM9 (Q319F9)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397922.1
- ProteinModelPortal:   Q319F9
- SMR:   Q319F9
- STRING:   Q319F9
- GeneID:   3766242
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1426
- eggNOG:   COG0284
- HOGENOM:   HBG625253
- OMA:   TVHAYPQ
- ProtClustDB:   CLSK922152
- BioCyc:   PMAR74546:PMT9312_1426-MONOMER
- HAMAP:   MF_01200_B
- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR01740

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 26871; Mature: 26871

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 66-66 BINDING 16-16 BINDING 37-37 BINDING 128-128 BINDING 190-190 BINDING 199-199 BINDING 219-219 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKK
CCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCHHHHHHHCCCCE
IFLDLKFHDIPNTMSAACFQVSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPF
EEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCC
VVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAELDGCVCSPWEVKMLRSIYKN
EEHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
NFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSID
CCEEECCCEEEEECCCCCCCCEECCCHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHC
SD
CC
>Mature Secondary Structure
MKNRFNSEDKIILAIDGLDLNQAKLLLEKCPSIKWVKVGLELFVREGPRVVEILKGLNKK
CCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCHHHHHHHCCCCE
IFLDLKFHDIPNTMSAACFQVSKLGVDIISVHSSAGLKALQDSKKASLEGASLANLKPPF
EEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCC
VVGITVLTSFSLKDFQTDLDRKNSIEDNVLRLAKLSFDAELDGCVCSPWEVKMLRSIYKN
EEHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
NFELITPGIRLKIDNKDDQNRIMTPNEAIDNGASKLVIGRSISKALDPNKALIEIFKSID
CCEEECCCEEEEECCCCCCCCEECCCHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHC
SD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA