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The map label for this gene is tyrS

Identifier: 78779811

GI number: 78779811

Start: 1339864

End: 1341102

Strand: Reverse

Name: tyrS

Synonym: PMT9312_1427

Alternate gene names: 78779811

Gene position: 1341102-1339864 (Counterclockwise)

Preceding gene: 78779812

Following gene: 78779810

Centisome position: 78.46

GC content: 31.72

Gene sequence:

>1239_bases
ATGTCAGATAAATTAATATTGCCATCATGGCTGTCAAGAGGAATAGAAGAATACTTCCCGATTAAAGGAATAGATCAAAC
TTTTTCGGAGATAATTGATGATGCGAAAAAAAACAATAAAAAATTAAGGGTTAAACTCGGAATCGACCCAACTGGAACAG
ATATTCACCTCGGGCACAGCATATTGTTTAAGAAACTTAGGGCATTCCAAGATAATGGACATATTGCAGTTTTAATTATT
GGTGATTTTACTGCTCAAATAGGCGACCCAACTGGGAAAAATAAAACAAGAGTGCAGTTATCTGAAAAACAAGTTAAAGA
TAATGCAAAAACATACTTAACCCAACTAGGAATGGGAAAGCCAGCTAATGAATCTATTTTAGATTTTGATTCAAAAGATA
AAATAGAAATTAGATATAACAGTGAATGGTTAAAAGGATTAAATCTTAATTCGATAATTGAATTAATGGGTAGTGCAACA
GTTAGTCAAATGCTAGCTAAGGAGGAATTTAATAAAAGGTATAATTCACAAGTTCCAATTGCTTTGCATGAATTCTTATA
TCCACTATTACAAGGTTATGATTCTGTAGTAGTTCAATCGGATATTGAGCTTGGAGGTACAGATCAGAAATTTAATATTG
CAATAGGTAGAGATCTGCAAAGGCATTTTAAACAAGAACCTCAATTTGGTGTTCTGCTGCCAATTTTGACAGGTTTAGAT
GGAATTAAGAAGATGAGTAAATCAGAATTTAACACCGTTGGCTTGACTGAAGACTCTCTTTCAATGTATTCAAAATTAGA
AAAAGTACCAGATAATATAATACCTACCTATTTTGAATTACTTACTGAATTAGATTTAAGTGTTCTTAATGATGCAAATC
CTCGTGAATTGCAGAGAAGAATGGCTTTAGAGGTTACTACTTTATTTCACGGTGCCGAAGAAGCATCAAAAGCGCAATCT
AATTGCGAAAAATTATTCCTTGGACATAAAGAGAAAGTTGGAGAAATTCCAGAGATTTCATTAAAAGATATTGTTTTTCC
GGTTAAATTTTTTTACTTGCTAAGTTCTTTAAAATTATTCAAATCTAGCAGTGAGTCCAAAAGATCTATAAAAGGCGGCG
GAGTAAAGATTGATAGCCAGAAAGTAATAAATCCCGATATAGTTTTTGACTCAAAAAAAGATTTAGAAGGTAAAATTTTA
CAAATTGGAAAAAAAATCATTAAGAGGTTTGAAAACTAA

Upstream 100 bases:

>100_bases
GGGATTACTCCTGATCAAATGTTCGATCAGATGAATAAAACTTTAATAAGAATGAAGGATGAACTTGATAAAACTTCTTA
AATCTAACGGTTAAAGCTTC

Downstream 100 bases:

>100_bases
AAATAAATGAAAAATAGATTTAATTCAGAAGATAAAATAATATTGGCAATTGATGGACTAGATCTAAATCAAGCAAAATT
ACTTCTAGAAAAATGTCCTA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSDKLILPSWLSRGIEEYFPIKGIDQTFSEIIDDAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDKIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYNSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLTEDSLSMYSKLEKVPDNIIPTYFELLTELDLSVLNDANPRELQRRMALEVTTLFHGAEEASKAQS
NCEKLFLGHKEKVGEIPEISLKDIVFPVKFFYLLSSLKLFKSSSESKRSIKGGGVKIDSQKVINPDIVFDSKKDLEGKIL
QIGKKIIKRFEN

Sequences:

>Translated_412_residues
MSDKLILPSWLSRGIEEYFPIKGIDQTFSEIIDDAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDKIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYNSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLTEDSLSMYSKLEKVPDNIIPTYFELLTELDLSVLNDANPRELQRRMALEVTTLFHGAEEASKAQS
NCEKLFLGHKEKVGEIPEISLKDIVFPVKFFYLLSSLKLFKSSSESKRSIKGGGVKIDSQKVINPDIVFDSKKDLEGKIL
QIGKKIIKRFEN
>Mature_411_residues
SDKLILPSWLSRGIEEYFPIKGIDQTFSEIIDDAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLIIG
DFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDKIEIRYNSEWLKGLNLNSIIELMGSATV
SQMLAKEEFNKRYNSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLDG
IKKMSKSEFNTVGLTEDSLSMYSKLEKVPDNIIPTYFELLTELDLSVLNDANPRELQRRMALEVTTLFHGAEEASKAQSN
CEKLFLGHKEKVGEIPEISLKDIVFPVKFFYLLSSLKLFKSSSESKRSIKGGGVKIDSQKVINPDIVFDSKKDLEGKILQ
IGKKIIKRFEN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=434, Percent_Identity=26.9585253456221, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1787925, Length=388, Percent_Identity=29.3814432989691, Blast_Score=128, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25145802, Length=308, Percent_Identity=25.974025974026, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=379, Percent_Identity=25.3298153034301, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130383, Length=372, Percent_Identity=26.0752688172043, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_PROM9 (Q319F8)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397923.1
- ProteinModelPortal:   Q319F8
- SMR:   Q319F8
- STRING:   Q319F8
- GeneID:   3766243
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1427
- eggNOG:   COG0162
- HOGENOM:   HBG288125
- OMA:   FKEGIPI
- ProtClustDB:   PRK05912
- BioCyc:   PMAR74546:PMT9312_1427-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02007
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 46427; Mature: 46296

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKLILPSWLSRGIEEYFPIKGIDQTFSEIIDDAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCCEECHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDKIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYNSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLTEDSLSMYSKLEKVPDNIIPTYFELLTELDLSVLNDANPRELQRR
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGAEEASKAQSNCEKLFLGHKEKVGEIPEISLKDIVFPVKFFYLLSSLKLF
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSQKVINPDIVFDSKKDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKLILPSWLSRGIEEYFPIKGIDQTFSEIIDDAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCEECHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDKIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYNSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLTEDSLSMYSKLEKVPDNIIPTYFELLTELDLSVLNDANPRELQRR
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGAEEASKAQSNCEKLFLGHKEKVGEIPEISLKDIVFPVKFFYLLSSLKLF
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSQKVINPDIVFDSKKDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA