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The map label for this gene is ppnK

Identifier: 78779747

GI number: 78779747

Start: 1280872

End: 1281780

Strand: Reverse

Name: ppnK

Synonym: PMT9312_1363

Alternate gene names: 78779747

Gene position: 1281780-1280872 (Counterclockwise)

Preceding gene: 78779748

Following gene: 78779745

Centisome position: 74.99

GC content: 39.05

Gene sequence:

>909_bases
TTGGTACTTAAAGCAGGACTAATAGTTAATGATGGGAAAGAACTAGCCGTTCAAACCGCAAGTTCTGTTCAGGAAAAATT
GGAAAAATCCAATTATGAGGTCATAAGGGTTAGTAGCTCTGGTGGAATGGTTGGATTTGCCAATCCTGATCAACATGTTC
GTCCATTGGGATATACCAATTGTGTTCCCGAGGGGTTTGATTCCTCAATGGAATTTGCAATTGTTCTTGGCGGAGATGGA
ACTGTGCTTTCTGCTGCAAGGCAAACGGCACCTGCAAAAATTCCAATCCTTACAATAAATACTGGTCATTTAGGATTTCT
TGCGGAAGCTTATTTATCCAACCTAAATGAAGCTATAGATAAAATTATTACTGGGAATTGGGATATTGAAGAAAGAACTT
GTTTTATCGTTAGTGTAATGAGGAATGATCAGAGGAGGTGGGAGTCTCTCTGCCTTAATGAGATGGCCCTTCATAGAGAA
CCTCTTACAAGTATGTGTCATTTTGAGATCTCTATAGGAAGACATGCCCCTGTGGATATTTCGGCTGATGGTGTAATCTT
ATCTACTCCAACTGGATCTACTGCATATTCTCTTAGTGCTGGAGGACCAGTTATTACTCCTGATTGTCCAGTTGTTCAAT
TAACTCCAATTGCGCCGCATTCATTGGCATCAAGGGCACTAGTTTTTAATGATTCAGAGCCAGTAACTGTTTTCCCTGCA
ACTCCTGAAAGATTAGTAATGGTTGTGGATGGAAATGCTGGTTGTTACGTTTGGCCTGAAGATAGAGTTTTGATAAGAAA
AAGTAAACACTCAGTTAAGTTTATTAGACTTGAAGATCATGAATTTTTTCAAGTATTAAGAAATAAACTAGGTTGGGGAT
TACCCCATGTGGCTAAACCAAACAAATAA

Upstream 100 bases:

>100_bases
AATGATCTTAGATTCTTAGAACAGTTTTAATAGAATTTAAGTTATAAATTATGATTGTCCAGCAAATTAGTTTAAAATAG
TTGTAGTTTTAGTTTTTTGA

Downstream 100 bases:

>100_bases
AAATTATCTTAATTTATTTTTTCCCTTTTAATAAAAATACAGGATTATTTGGTTCTAATCTCATTCCTTCTGCGATACTT
AAACTTTTGTAAGTCTGTAT

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase 2

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTNCVPEGFDSSMEFAIVLGGDG
TVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAIDKIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHRE
PLTSMCHFEISIGRHAPVDISADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPA
TPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKPNK

Sequences:

>Translated_302_residues
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTNCVPEGFDSSMEFAIVLGGDG
TVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAIDKIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHRE
PLTSMCHFEISIGRHAPVDISADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPA
TPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKPNK
>Mature_302_residues
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTNCVPEGFDSSMEFAIVLGGDG
TVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAIDKIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHRE
PLTSMCHFEISIGRHAPVDISADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPA
TPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKPNK

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=261, Percent_Identity=26.4367816091954, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1788968, Length=223, Percent_Identity=35.8744394618834, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320794, Length=251, Percent_Identity=31.8725099601594, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325068, Length=169, Percent_Identity=31.9526627218935, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322509, Length=250, Percent_Identity=26.8, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28573828, Length=247, Percent_Identity=27.1255060728745, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28573830, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077047, Length=250, Percent_Identity=27.6, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573832, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573826, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363321, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363323, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653424, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129957, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653422, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK2_PROM9 (Q319M2)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397859.1
- ProteinModelPortal:   Q319M2
- SMR:   Q319M2
- STRING:   Q319M2
- GeneID:   3766175
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1363
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   CVPEGFD
- ProtClustDB:   PRK02649
- BioCyc:   PMAR74546:PMT9312_1363-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 32932; Mature: 32932

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTN
CEEEECEEEECCHHHEEECHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCCCCCC
CVPEGFDSSMEFAIVLGGDGTVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAID
CCCCCCCCCCEEEEEECCCCCEEHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
KIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHREPLTSMCHFEISIGRHAPVDI
HHHCCCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEE
SADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPA
CCCCEEEECCCCCCEEEECCCCCEECCCCCEEEEECCCCHHHHCEEEEEECCCCEEEEEC
TPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKP
CCCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCC
NK
CC
>Mature Secondary Structure
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTN
CEEEECEEEECCHHHEEECHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCCCCCC
CVPEGFDSSMEFAIVLGGDGTVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAID
CCCCCCCCCCEEEEEECCCCCEEHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
KIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHREPLTSMCHFEISIGRHAPVDI
HHHCCCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEE
SADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPA
CCCCEEEECCCCCCEEEECCCCCEECCCCCEEEEECCCCHHHHCEEEEEECCCCEEEEEC
TPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKP
CCCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCC
NK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA