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The map label for this gene is pntAA [H]

Identifier: 78779627

GI number: 78779627

Start: 1159446

End: 1160621

Strand: Reverse

Name: pntAA [H]

Synonym: PMT9312_1244

Alternate gene names: 78779627

Gene position: 1160621-1159446 (Counterclockwise)

Preceding gene: 78779631

Following gene: 78779626

Centisome position: 67.9

GC content: 36.39

Gene sequence:

>1176_bases
TTGACTTTCTTCAATTTATATTTAGTATGTAAAAAAATAAATAAATTGACAAAGATACTTATTCCTTCCGAAACTAGCTC
TGGTGAAAGGAGAGTTTCAGCTACTCCAGAAGCCGTAAAGAAATTAAAAAGCCATGGATGTGATGTATATATTGAAAGTT
CAGCAGGAAAATTATCAGGATTTAGTGACTTATCATATGAAGAGTCGGGCGGCACAATAATCAGTAACTTAGATCAAAAC
ATTTGGGGTGAAGCGGACATGATATTTTGTGTTCAAACTCCATCAGAGGATAATTTAATTAAATTAAAAAATGGTGCTGT
TCTGCTTGGCCTTCTTAACCCATACGGTAACAAAGATCTTCTTAAGATAATAAATAGTAATAAGATTTCAGCTTTATCAC
TAGAGTTGCTTCCCAGAATTAGTAGGGCTCAATCTTCTGATGTTCTTTCTTCACAGGCTAATATTGCAGGATACAAAGCA
GTCCTTTTAGCAGCAAGTGAGTTAGATAGATATTTCCCCATGCTGATGACTGCAGCAGGCACTGTTCAACCTGCCAAAGT
TGTGGTTCTAGGTGGTGGCGTTGCAGGATTGCAGGCAGTTGCTACAGCAAAAAGACTTGGTGCAATAGTTTTTGTATCCG
ATATAAGGCCTGCTGTTAAAGAACAAGTTGAGTCCCTAGGCGCAAGATTTATAGAACTTCCTGAAGTTGACGAAAAACCA
GGAGAGGCAGGAGGCTACGCAAAAGCTGTAACTCCTGAATTTCTTTCAAAACAGAAGGCTACTTTAACTAAATATTTATC
TGAAGCAGATGTTGCCATCTGTACTGCACAAGTTTTGGGTAAAAAGGCACCTGTTTTAATAGACTCTCCAATGCTTGAAA
AAATGAGACCTGGGGCTGTAGTGATAGATTTGGCAGTTTCTCAAGGAGGTAATTGCGAAGGAACAAAATCAAATGAAACT
ATTATCAAAGATGGTGTAAAGCTTATAGGTGCTGGTGAATTACCTTCATCAGTTCCTTACGATGCGAGTTCACTTTATGC
TAAAAATTTAACATCTTTAATTACACCATTCATAAAAGATGGTGTAATTAAATTAGATAAAGAGGATGAACTTATTTCTG
GATGTTTATTAAGTGATGAAGGAGTTGTCCTTCAAAATAAAGTTTTTGAAAATTGA

Upstream 100 bases:

>100_bases
TCGATTGCTTTTATACTCATTGGATTATTAGTACCTATATATATTTGATAGCTATTTTTTATAGAAAAGAAAATATATTT
TTAACAAAAATCCAAGACTT

Downstream 100 bases:

>100_bases
GGTATTAGAATTATGTCTTTTATAAGTCTTCTTTGGGTCCTTTTACTTGGTAGTTTGTTAGGCCTGGAGTTAATTGGAAA
AGTTCCTCCAACGCTTCATA

Product: putative nicotinamide nucleotide transhydrogenase, subunit alpha 1 (A1)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTFFNLYLVCKKINKLTKILIPSETSSGERRVSATPEAVKKLKSHGCDVYIESSAGKLSGFSDLSYEESGGTIISNLDQN
IWGEADMIFCVQTPSEDNLIKLKNGAVLLGLLNPYGNKDLLKIINSNKISALSLELLPRISRAQSSDVLSSQANIAGYKA
VLLAASELDRYFPMLMTAAGTVQPAKVVVLGGGVAGLQAVATAKRLGAIVFVSDIRPAVKEQVESLGARFIELPEVDEKP
GEAGGYAKAVTPEFLSKQKATLTKYLSEADVAICTAQVLGKKAPVLIDSPMLEKMRPGAVVIDLAVSQGGNCEGTKSNET
IIKDGVKLIGAGELPSSVPYDASSLYAKNLTSLITPFIKDGVIKLDKEDELISGCLLSDEGVVLQNKVFEN

Sequences:

>Translated_391_residues
MTFFNLYLVCKKINKLTKILIPSETSSGERRVSATPEAVKKLKSHGCDVYIESSAGKLSGFSDLSYEESGGTIISNLDQN
IWGEADMIFCVQTPSEDNLIKLKNGAVLLGLLNPYGNKDLLKIINSNKISALSLELLPRISRAQSSDVLSSQANIAGYKA
VLLAASELDRYFPMLMTAAGTVQPAKVVVLGGGVAGLQAVATAKRLGAIVFVSDIRPAVKEQVESLGARFIELPEVDEKP
GEAGGYAKAVTPEFLSKQKATLTKYLSEADVAICTAQVLGKKAPVLIDSPMLEKMRPGAVVIDLAVSQGGNCEGTKSNET
IIKDGVKLIGAGELPSSVPYDASSLYAKNLTSLITPFIKDGVIKLDKEDELISGCLLSDEGVVLQNKVFEN
>Mature_390_residues
TFFNLYLVCKKINKLTKILIPSETSSGERRVSATPEAVKKLKSHGCDVYIESSAGKLSGFSDLSYEESGGTIISNLDQNI
WGEADMIFCVQTPSEDNLIKLKNGAVLLGLLNPYGNKDLLKIINSNKISALSLELLPRISRAQSSDVLSSQANIAGYKAV
LLAASELDRYFPMLMTAAGTVQPAKVVVLGGGVAGLQAVATAKRLGAIVFVSDIRPAVKEQVESLGARFIELPEVDEKPG
EAGGYAKAVTPEFLSKQKATLTKYLSEADVAICTAQVLGKKAPVLIDSPMLEKMRPGAVVIDLAVSQGGNCEGTKSNETI
IKDGVKLIGAGELPSSVPYDASSLYAKNLTSLITPFIKDGVIKLDKEDELISGCLLSDEGVVLQNKVFEN

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=340, Percent_Identity=40, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI122939153, Length=340, Percent_Identity=40, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI1787887, Length=367, Percent_Identity=40.5994550408719, Blast_Score=268, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=364, Percent_Identity=41.4835164835165, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 41630; Mature: 41498

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFNLYLVCKKINKLTKILIPSETSSGERRVSATPEAVKKLKSHGCDVYIESSAGKLSG
CCHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCC
FSDLSYEESGGTIISNLDQNIWGEADMIFCVQTPSEDNLIKLKNGAVLLGLLNPYGNKDL
CCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEEEECCCCCCHHH
LKIINSNKISALSLELLPRISRAQSSDVLSSQANIAGYKAVLLAASELDRYFPMLMTAAG
HHHHCCCCCEEEHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TVQPAKVVVLGGGVAGLQAVATAKRLGAIVFVSDIRPAVKEQVESLGARFIELPEVDEKP
CCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEHHCCHHHHHHHHHHCCCEEECCCCCCCC
GEAGGYAKAVTPEFLSKQKATLTKYLSEADVAICTAQVLGKKAPVLIDSPMLEKMRPGAV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEECCHHHHHCCCCEE
VIDLAVSQGGNCEGTKSNETIIKDGVKLIGAGELPSSVPYDASSLYAKNLTSLITPFIKD
EEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GVIKLDKEDELISGCLLSDEGVVLQNKVFEN
CEEEECCCHHHHHCEEECCCCEEECCCCCCC
>Mature Secondary Structure 
TFFNLYLVCKKINKLTKILIPSETSSGERRVSATPEAVKKLKSHGCDVYIESSAGKLSG
CHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCC
FSDLSYEESGGTIISNLDQNIWGEADMIFCVQTPSEDNLIKLKNGAVLLGLLNPYGNKDL
CCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEEEECCCCCCHHH
LKIINSNKISALSLELLPRISRAQSSDVLSSQANIAGYKAVLLAASELDRYFPMLMTAAG
HHHHCCCCCEEEHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TVQPAKVVVLGGGVAGLQAVATAKRLGAIVFVSDIRPAVKEQVESLGARFIELPEVDEKP
CCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEHHCCHHHHHHHHHHCCCEEECCCCCCCC
GEAGGYAKAVTPEFLSKQKATLTKYLSEADVAICTAQVLGKKAPVLIDSPMLEKMRPGAV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEECCHHHHHCCCCEE
VIDLAVSQGGNCEGTKSNETIIKDGVKLIGAGELPSSVPYDASSLYAKNLTSLITPFIKD
EEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GVIKLDKEDELISGCLLSDEGVVLQNKVFEN
CEEEECCCHHHHHCEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]