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The map label for this gene is pgl [H]

Identifier: 78779163

GI number: 78779163

Start: 727822

End: 728559

Strand: Direct

Name: pgl [H]

Synonym: PMT9312_0779

Alternate gene names: 78779163

Gene position: 727822-728559 (Clockwise)

Preceding gene: 78779162

Following gene: 78779164

Centisome position: 42.58

GC content: 29.13

Gene sequence:

>738_bases
ATGGATGAAATGATTGAAAAGGTTAAAAATGGTTATAACCTAAACATTTACAAAGACAAGTTAGAGCTATCAACAGCTGT
TTTTAAATTTATTGAAAGTCACATTATTCATACTTTAAAAAAGAAATGCAGATTCAAATTCTGTGTGAGTGGAGGTTCAA
CTCCTAAATCTGTTTATCAGCTTCTATCAATAAGTGATCTTAGATGGGATATGGTTGATGTCTTTTTAGGAGATGAAAGG
TGTGTTGATCCAAATTCAGAATTAAGTAACTCGTTAATGTTGAAAAAATCATTATTAACTAATTTTGGATCTAAAGCTTT
TTTTTATGAGATTTTTAATGATTTAAAGGCTGATGATGAAGCGACAAAAAATCAATTTATTTCTAAATTATTTGAAAAAT
GCGGATCAAACCCTCCAACCTTTGATTTAACATTATTAGGTCTTGGAGACGATGGTCATACAGCTTCACTATTCCCTTAT
CAAAAAAATAATAACGCAGATGATTTTGTGATTTTTAATGAAGGTAAAGGATTAAAAAGAATTTCATTAACTCCAAAGGT
TCTTTCAGCCTCTTCGAAGATAGTATTTTTGGTTAGTGGAGCTTCTAAAAGAATTGCTCTTGAGAGGTTATTAGATGAAA
AAGAGCCATCAGATAGAACACCATCAAAATTAATAAAATCTATTAATCAAATTTCAATATTTTGTGATCAGGAATCAGCA
AAAGAATTAGAAATTTAG

Upstream 100 bases:

>100_bases
GAACCAATAGACTTCCTCAGAATCTTGTTCAGGCAATGAGAGACTGTTTTGGCTCTCACACATATCAAAGAATTGATAAG
GAAGGTAGTTTTCATACTGA

Downstream 100 bases:

>100_bases
TTAAAGTCTAATAATAATTAAAAGTATTTAATGAATAAGAAAAAAATTTTATTCCAGAAAAAGGAGTTCGATGGTTGGGA
AACATTAAATGATACTGTTA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MDEMIEKVKNGYNLNIYKDKLELSTAVFKFIESHIIHTLKKKCRFKFCVSGGSTPKSVYQLLSISDLRWDMVDVFLGDER
CVDPNSELSNSLMLKKSLLTNFGSKAFFYEIFNDLKADDEATKNQFISKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNADDFVIFNEGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKEPSDRTPSKLIKSINQISIFCDQESA
KELEI

Sequences:

>Translated_245_residues
MDEMIEKVKNGYNLNIYKDKLELSTAVFKFIESHIIHTLKKKCRFKFCVSGGSTPKSVYQLLSISDLRWDMVDVFLGDER
CVDPNSELSNSLMLKKSLLTNFGSKAFFYEIFNDLKADDEATKNQFISKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNADDFVIFNEGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKEPSDRTPSKLIKSINQISIFCDQESA
KELEI
>Mature_245_residues
MDEMIEKVKNGYNLNIYKDKLELSTAVFKFIESHIIHTLKKKCRFKFCVSGGSTPKSVYQLLSISDLRWDMVDVFLGDER
CVDPNSELSNSLMLKKSLLTNFGSKAFFYEIFNDLKADDEATKNQFISKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPY
QKNNNADDFVIFNEGKGLKRISLTPKVLSASSKIVFLVSGASKRIALERLLDEKEPSDRTPSKLIKSINQISIFCDQESA
KELEI

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533058, Length=237, Percent_Identity=25.3164556962025, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115533060, Length=237, Percent_Identity=25.3164556962025, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=29.3023255813954, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319918, Length=212, Percent_Identity=28.7735849056604, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321957, Length=243, Percent_Identity=27.1604938271605, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321687, Length=219, Percent_Identity=31.0502283105023, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 27647; Mature: 27647

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEMIEKVKNGYNLNIYKDKLELSTAVFKFIESHIIHTLKKKCRFKFCVSGGSTPKSVYQ
CHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
LLSISDLRWDMVDVFLGDERCVDPNSELSNSLMLKKSLLTNFGSKAFFYEIFNDLKADDE
HHHHCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
ATKNQFISKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPYQKNNNADDFVIFNEGKGLKR
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCCCEE
ISLTPKVLSASSKIVFLVSGASKRIALERLLDEKEPSDRTPSKLIKSINQISIFCDQESA
EECCHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCC
KELEI
CCCCC
>Mature Secondary Structure
MDEMIEKVKNGYNLNIYKDKLELSTAVFKFIESHIIHTLKKKCRFKFCVSGGSTPKSVYQ
CHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
LLSISDLRWDMVDVFLGDERCVDPNSELSNSLMLKKSLLTNFGSKAFFYEIFNDLKADDE
HHHHCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
ATKNQFISKLFEKCGSNPPTFDLTLLGLGDDGHTASLFPYQKNNNADDFVIFNEGKGLKR
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCCCEE
ISLTPKVLSASSKIVFLVSGASKRIALERLLDEKEPSDRTPSKLIKSINQISIFCDQESA
EECCHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCC
KELEI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]