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The map label for this gene is gnd [H]

Identifier: 78779162

GI number: 78779162

Start: 726416

End: 727834

Strand: Direct

Name: gnd [H]

Synonym: PMT9312_0778

Alternate gene names: 78779162

Gene position: 726416-727834 (Clockwise)

Preceding gene: 78779161

Following gene: 78779163

Centisome position: 42.5

GC content: 35.52

Gene sequence:

>1419_bases
ATGTCCAAGGCGCATTTTGGTTTAGTAGGTCTTGGTGTTATGGGCGAAAATTTAGTTCTTAACGCAGAAAGAAATGGATT
TTCAAGTGTAGTTTTTAATAGAACTTATTCAAAAACTGAAGAATTTTTACAAGGTCGAGGCCTTGGGAAGAATATAGAGG
GAGCTGAAACTCTTCAAGAATTTGTCAATAAGCTAGAGAGACCCAGAAGAATTTTAATGATGGTAAAAGCTGGACCAGCA
ACAGATGCGGTTATAGAAAACATTTCTGGATATCTCGAGGAAGGAGATTTATTGATAGATGGCGGTAATTCTCAATTTAA
AGATACAGAAAGAAGGGTGAATACTCTTGAAAGTAAAAGTTTTGGATACATTGGAATGGGAGTTTCAGGTGGTGCAAAAG
GAGCTCTTGAAGGGCCAAGTATGATGCCTGGCGGTACTAAAGCTTCATATGATGCAATAGAAAGCTTATTAACAAAAATG
GCTGCCAAAGTTGAAGACGGGCCATGTGTTGCATATGTTGGACCAGGAGGCTCAGGTCATTTTGTAAAAACTGTTCATAA
CGGAATTGAATATGGAATTGAACAAATACTTGCAGAAGCTTATGACCTTATGAAGAGAGTCAAAGGTATGAACGGTCAGC
AAATGTCAGAGGTATTTGGTATTTGGAATAATACTGATGAATTAGCTTCTTATCTTGTTGAGATTACGGAGATTTGTCTA
AATACAAAAGATGAGATAACTGGTGATGATGTCGTGGAGAAAATATTAGATAAAGCTGGCCAGAAAGGTACTGGTTTATG
GACTGTTGTAAGTGCTTTAGAACTGGGGGTGTCAGTCCCAACTATTTATGCTTCTTTAAATGCAAGAGTAATGAGTTCTT
TAAAAGAGCAACGTAGTGAGATTGAAAAAACTATTCCATCTAAAGAGATAGAGGATTTCGATTTAGGAAATATATCTGAT
GGAATGAAACCTTTATTTGATGCTGTAGTCCTTGCCACAATAGCTAGCTATGCTCAAGGTATGGACATTTTAAGAGAAGC
ATCTACAGTATATAACTATGGTTTGAATATGCCGTCAATTGCTCAAATATGGAAGGGTGGTTGCATAATTAGATCAAAAT
TATTAAGTAAAATTCAAGATGCTTATAACAAAGATCCTAATTTAAAAAATTTAATTTTTGATGATTGGTTCAATAATGAA
ATTGCGACAAGATTAGATAACTTAGCTAAAGTCGTTTCTTTATCCACAAAAGCTGGTATACCAGTCCCATGTCTATCCAG
TACTTTAGATTATTTGAATAGTTATAGAACCAATAGACTTCCTCAGAATCTTGTTCAGGCAATGAGAGACTGTTTTGGCT
CTCACACATATCAAAGAATTGATAAGGAAGGTAGTTTTCATACTGAATGGATGAAATGA

Upstream 100 bases:

>100_bases
ATTTAATTCGTTTCGATCATTTTTCGCTGACATAAGTATTTTTTTTGAGCAATTTTGTTGAGTTGCGGGCAAACTATATT
TATTGAGTTTTTTATTTTTT

Downstream 100 bases:

>100_bases
TTGAAAAGGTTAAAAATGGTTATAACCTAAACATTTACAAAGACAAGTTAGAGCTATCAACAGCTGTTTTTAAATTTATT
GAAAGTCACATTATTCATAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKAHFGLVGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIENISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASTVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYQRIDKEGSFHTEWMK

Sequences:

>Translated_472_residues
MSKAHFGLVGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIENISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASTVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYQRIDKEGSFHTEWMK
>Mature_471_residues
SKAHFGLVGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQEFVNKLERPRRILMMVKAGPAT
DAVIENISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMA
AKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICLN
TKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSEIEKTIPSKEIEDFDLGNISDG
MKPLFDAVVLATIASYAQGMDILREASTVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEI
ATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYQRIDKEGSFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=46.1864406779661, Blast_Score=415, Evalue=1e-116,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=47.8813559322034, Blast_Score=440, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=44.0677966101695, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321695, Length=474, Percent_Identity=44.3037974683544, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=45.4945054945055, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=43.7367303609342, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51735; Mature: 51603

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHFGLVGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQE
CCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIENISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKEIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASTVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYQRIDKEGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKAHFGLVGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKNIEGAETLQE
CCCCCCEEECCCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIENISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKEIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASTVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPNLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYQRIDKEGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]