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The map label for this gene is lig [H]

Identifier: 78779117

GI number: 78779117

Start: 685111

End: 686751

Strand: Reverse

Name: lig [H]

Synonym: PMT9312_0733

Alternate gene names: 78779117

Gene position: 686751-685111 (Counterclockwise)

Preceding gene: 78779118

Following gene: 78779116

Centisome position: 40.18

GC content: 27.61

Gene sequence:

>1641_bases
ATGAGCTTAAAAAATTTTTCAGAATTATTTCTAGATTTAGATTCAAGTAACAGCACAAATAATAAAATTGAAGTTTTAAA
GAATTATTTTTTATCTAATGATCCAATAGATAATTCATGGGCAATAAATTTACTGACTGGAAAAAGTAATAAGAGATTTA
TTAGCGGAAGATATTTAAAAAATCTTTTTTCTCAAATATATGAATATCCTGAATGGTTAATTGATACATGCTATTTAAAA
GTTGGTGATTCTGCTGAGGTAATAACGTTATTACTTAAAAATAAAAGTACTTCCAAAAAAAAGAAATTATCAAATATAAG
TCTCAATGAATTACTAAGCAAAACCATACCTGATTTATCAAAACTTAATGAGGAGGAGAAAAATTTTAAAATTAAAAATA
TGTGGGAAACATTACCTGAAGATAACCATCTAATTTTCAATAAGATTCTTACAGGAACTTTTAGAGTAGGGGTCTCTATC
GGATTAATCACAAAATCAATATCAAAACTAATTAATATTGATGAAGAGATTATTTCCCATAGGTTGATGGGGAATTTTGA
GCCTTCAATTGATTCATATGAATTTTTAATTAACAAGAATATCAATCTTCAAGAGTTAAATTCCAAACCATTTCCATTTC
TTCTAGCGAATACTATTGAAGATAAAATCTTCAAACATTCAATAAATGATTTTCAATTTGAATGGAAATACGACGGTATA
AGGATGCAATTAATTAAAAGATCAGGAAATGTTTCGTTATGGACAAGAGGGCAAGAATTAGTCAATGAATCATTCCCAGA
ATTAGTAGAGAAAATGTCGCATATAAAAGATGATTTTGTTCTTGATGGTGAATTATTAGTTTGGAATTTTAAAGAACAAA
TTGCGTTTGATTTTTCTTTTCTTCAAAAAAGAATAAATAGAAAATCTCCTACTAGATCAATCCAATTAAAATATCCAATT
ATTTTTATTGCTTATGATCTTTTAGAGATTAATGGAAGAGATATAAGAGAAATTAAATTAGAGAATAGAAGAATTGAGTT
AGAAAAATATTTTTCAAAATGGCAAAATAAAACTGAGAATGATATCTCTGATATTTTCAAAATATGTGATTTAATCTTTC
CTAAAGATTGGCCTGATGCTTTAACTTATAGAGAGAAATCTCGAGAAAATAATACTGAAGGATTAATAATTAAGAAAAAG
ACTTCTATATACTCCCCTGGTCGAAAAAAAGGCATTTGGTGGAAATATAAAGTTGATCCTATGCAACTGGATGCTGTTCT
AATTTACGCAAAGGGCGGTAGCGGTAGAAGAGCTGGTCTTTATACAGATTACAGTTTTGCATTATGGAAAGACCAAGAAT
TAATTAAATTTGCAAGTGCATATTCTGGTTTAACAAATATTGAGATCAAAGAGCTAGATAAATGGATAAGGAACAATACA
ATAGAAAAATTTGGTCCTGTTCGATCGTTAAAACCAGAAATGGTATTTGAAATATCTTTTGAGAAAATACAAATTTCAAA
ACGTCATAAGTCAGGCATAGCAGTAAGATTTCCAAGAATAACGAAATGGAGAAAAGATAAAAAAATTAATGATGCAGATA
GTCTAGAGAATGCTTATGCACTGATGAAAAAAATATCATGA

Upstream 100 bases:

>100_bases
AAGCAAAAAATGTATTTTTTCATCATGGAGATAGTGAAGCTTTAAGTAAATTTTTAGTTGAGAAGGAATCAATAAATGTT
CTTTTCTTCGGTAAATAAAT

Downstream 100 bases:

>100_bases
ATAATATTAAACAAAATAGTAGGCAAAGTAATTCTATTTCTAAAATTAAACAGTTTTTCTTCTCAAATGGATGGGAGCCA
TTAACCTACCAAGAAGAATC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MSLKNFSELFLDLDSSNSTNNKIEVLKNYFLSNDPIDNSWAINLLTGKSNKRFISGRYLKNLFSQIYEYPEWLIDTCYLK
VGDSAEVITLLLKNKSTSKKKKLSNISLNELLSKTIPDLSKLNEEEKNFKIKNMWETLPEDNHLIFNKILTGTFRVGVSI
GLITKSISKLINIDEEIISHRLMGNFEPSIDSYEFLINKNINLQELNSKPFPFLLANTIEDKIFKHSINDFQFEWKYDGI
RMQLIKRSGNVSLWTRGQELVNESFPELVEKMSHIKDDFVLDGELLVWNFKEQIAFDFSFLQKRINRKSPTRSIQLKYPI
IFIAYDLLEINGRDIREIKLENRRIELEKYFSKWQNKTENDISDIFKICDLIFPKDWPDALTYREKSRENNTEGLIIKKK
TSIYSPGRKKGIWWKYKVDPMQLDAVLIYAKGGSGRRAGLYTDYSFALWKDQELIKFASAYSGLTNIEIKELDKWIRNNT
IEKFGPVRSLKPEMVFEISFEKIQISKRHKSGIAVRFPRITKWRKDKKINDADSLENAYALMKKIS

Sequences:

>Translated_546_residues
MSLKNFSELFLDLDSSNSTNNKIEVLKNYFLSNDPIDNSWAINLLTGKSNKRFISGRYLKNLFSQIYEYPEWLIDTCYLK
VGDSAEVITLLLKNKSTSKKKKLSNISLNELLSKTIPDLSKLNEEEKNFKIKNMWETLPEDNHLIFNKILTGTFRVGVSI
GLITKSISKLINIDEEIISHRLMGNFEPSIDSYEFLINKNINLQELNSKPFPFLLANTIEDKIFKHSINDFQFEWKYDGI
RMQLIKRSGNVSLWTRGQELVNESFPELVEKMSHIKDDFVLDGELLVWNFKEQIAFDFSFLQKRINRKSPTRSIQLKYPI
IFIAYDLLEINGRDIREIKLENRRIELEKYFSKWQNKTENDISDIFKICDLIFPKDWPDALTYREKSRENNTEGLIIKKK
TSIYSPGRKKGIWWKYKVDPMQLDAVLIYAKGGSGRRAGLYTDYSFALWKDQELIKFASAYSGLTNIEIKELDKWIRNNT
IEKFGPVRSLKPEMVFEISFEKIQISKRHKSGIAVRFPRITKWRKDKKINDADSLENAYALMKKIS
>Mature_545_residues
SLKNFSELFLDLDSSNSTNNKIEVLKNYFLSNDPIDNSWAINLLTGKSNKRFISGRYLKNLFSQIYEYPEWLIDTCYLKV
GDSAEVITLLLKNKSTSKKKKLSNISLNELLSKTIPDLSKLNEEEKNFKIKNMWETLPEDNHLIFNKILTGTFRVGVSIG
LITKSISKLINIDEEIISHRLMGNFEPSIDSYEFLINKNINLQELNSKPFPFLLANTIEDKIFKHSINDFQFEWKYDGIR
MQLIKRSGNVSLWTRGQELVNESFPELVEKMSHIKDDFVLDGELLVWNFKEQIAFDFSFLQKRINRKSPTRSIQLKYPII
FIAYDLLEINGRDIREIKLENRRIELEKYFSKWQNKTENDISDIFKICDLIFPKDWPDALTYREKSRENNTEGLIIKKKT
SIYSPGRKKGIWWKYKVDPMQLDAVLIYAKGGSGRRAGLYTDYSFALWKDQELIKFASAYSGLTNIEIKELDKWIRNNTI
EKFGPVRSLKPEMVFEISFEKIQISKRHKSGIAVRFPRITKWRKDKKINDADSLENAYALMKKIS

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=353, Percent_Identity=25.4957507082153, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985269, Length=370, Percent_Identity=27.8378378378378, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320038, Length=340, Percent_Identity=22.3529411764706, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24762424, Length=493, Percent_Identity=22.5152129817444, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI85815841, Length=364, Percent_Identity=25.2747252747253, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 64039; Mature: 63907

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKNFSELFLDLDSSNSTNNKIEVLKNYFLSNDPIDNSWAINLLTGKSNKRFISGRYLK
CCCCCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECHHHHH
NLFSQIYEYPEWLIDTCYLKVGDSAEVITLLLKNKSTSKKKKLSNISLNELLSKTIPDLS
HHHHHHHHCHHHHHHHHHEEECCCHHEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCHH
KLNEEEKNFKIKNMWETLPEDNHLIFNKILTGTFRVGVSIGLITKSISKLINIDEEIISH
HCCCHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHEEHHHHHHHHHHHHCCCHHHHHH
RLMGNFEPSIDSYEFLINKNINLQELNSKPFPFLLANTIEDKIFKHSINDFQFEWKYDGI
HHCCCCCCCCCCEEEEEECCCCCEECCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCE
RMQLIKRSGNVSLWTRGQELVNESFPELVEKMSHIKDDFVLDGELLVWNFKEQIAFDFSF
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECHHHHHHHHHH
LQKRINRKSPTRSIQLKYPIIFIAYDLLEINGRDIREIKLENRRIELEKYFSKWQNKTEN
HHHHHCCCCCCCEEEEECCEEEEEEEHHHCCCCCEEEEEECCCEEHHHHHHHHHCCCCCC
DISDIFKICDLIFPKDWPDALTYREKSRENNTEGLIIKKKTSIYSPGRKKGIWWKYKVDP
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCC
MQLDAVLIYAKGGSGRRAGLYTDYSFALWKDQELIKFASAYSGLTNIEIKELDKWIRNNT
EEEEEEEEEEECCCCCCCCEEECCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
IEKFGPVRSLKPEMVFEISFEKIQISKRHKSGIAVRFPRITKWRKDKKINDADSLENAYA
HHHHCCCCCCCCCEEEEEEHHHEEEEHHCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHH
LMKKIS
HHHHCC
>Mature Secondary Structure 
SLKNFSELFLDLDSSNSTNNKIEVLKNYFLSNDPIDNSWAINLLTGKSNKRFISGRYLK
CCCCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECHHHHH
NLFSQIYEYPEWLIDTCYLKVGDSAEVITLLLKNKSTSKKKKLSNISLNELLSKTIPDLS
HHHHHHHHCHHHHHHHHHEEECCCHHEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCHH
KLNEEEKNFKIKNMWETLPEDNHLIFNKILTGTFRVGVSIGLITKSISKLINIDEEIISH
HCCCHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHEEHHHHHHHHHHHHCCCHHHHHH
RLMGNFEPSIDSYEFLINKNINLQELNSKPFPFLLANTIEDKIFKHSINDFQFEWKYDGI
HHCCCCCCCCCCEEEEEECCCCCEECCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCE
RMQLIKRSGNVSLWTRGQELVNESFPELVEKMSHIKDDFVLDGELLVWNFKEQIAFDFSF
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECHHHHHHHHHH
LQKRINRKSPTRSIQLKYPIIFIAYDLLEINGRDIREIKLENRRIELEKYFSKWQNKTEN
HHHHHCCCCCCCEEEEECCEEEEEEEHHHCCCCCEEEEEECCCEEHHHHHHHHHCCCCCC
DISDIFKICDLIFPKDWPDALTYREKSRENNTEGLIIKKKTSIYSPGRKKGIWWKYKVDP
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCC
MQLDAVLIYAKGGSGRRAGLYTDYSFALWKDQELIKFASAYSGLTNIEIKELDKWIRNNT
EEEEEEEEEEECCCCCCCCEEECCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
IEKFGPVRSLKPEMVFEISFEKIQISKRHKSGIAVRFPRITKWRKDKKINDADSLENAYA
HHHHCCCCCCCCCEEEEEEHHHEEEEHHCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHH
LMKKIS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA