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The map label for this gene is menB [H]

Identifier: 78778993

GI number: 78778993

Start: 572390

End: 573247

Strand: Direct

Name: menB [H]

Synonym: PMT9312_0608

Alternate gene names: 78778993

Gene position: 572390-573247 (Clockwise)

Preceding gene: 78778992

Following gene: 78778994

Centisome position: 33.49

GC content: 35.78

Gene sequence:

>858_bases
ATGAAAGTCTTACCTGGGAAAACTACTTTAAATTGGTCACAATATAAATCTTATGAGGATATATTGTTTCATAAATCAGA
TGAGGGAATTGCGCGAATCGCAATTAATCGACCCGAGAAAAGAAATGCATTCAGACCTCAAACTGTAGATGAGCTTATTG
AGGCATTTAATATTGTGAGAAATGATGAAACTATTGGAGTAGTTCTTTTTACTGGTGCAGGCCCCGATAAGAAAGGTATT
TATTCTTTTTGCTCTGGAGGCGATCAGAGTGTTAGAGGTGAGAATGGATATAAAAATGATGAAGGGAAGCAAAGATTAAA
TGTACTGGAATTACAAAGATTAATTAGAAGTTTGCCCAAAGTGGTTATCGCATTAGTTCCTGGTTATGCAATTGGAGGAG
GTCAGGTTCTTCATTTGATTTGTGATCTTAGCATCGCTTCAGAAAATGCAATATTTGGTCAAACAGGTCCAAGAGTTGGT
AGCTTTGATGCCGGATTTGGTTCTAGTTATTTAGCTAGACTTGTTGGTCAAAGAAAAGCAAAGGAAATTTGGTTTTTATG
TAGAAAATATAATTCCAAGGAAGCTCTAGACATGGGCTTGATAAATGCAATTACAAAGATTGAAGAATTAGAAGCTCAGG
GTGTAATCTGGGCAAGAGAGATTTTACGAAATAGTCCAACTGCTATTCGTATTCTTAAAGCTTCATTTAATGCGGAAAAT
GATGGAATTGCTGGTATTCAAGAATTATCTGGATACACAACTCAATTATTTTATTCGACTAAAGAAGCTCAAGAAGGAAG
AGATTCCTTTCTTGAAAAACGTTCACCTGATTTTTCAGACTATAAGTGGACTCCCTAG

Upstream 100 bases:

>100_bases
TATCGATCCGGAGAATGAAATTAGTGACAAAAATGCCCTGTTAGAAAAAATAATTGGCAGTTAATTTTTTTTATTTTCTA
TTTTTGAATAATTAGGTTTC

Downstream 100 bases:

>100_bases
TTGATTTTTTCAAAAGAACTTTTTTATAACTATCAATGAGAATTCTTCTTGCCGCTGCTGAATGTGCTCCAATGATCAAA
GTTGGTGGAATGGGAGATGT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKVLPGKTTLNWSQYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELIEAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGYAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALDMGLINAITKIEELEAQGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTKEAQEGRDSFLEKRSPDFSDYKWTP

Sequences:

>Translated_285_residues
MKVLPGKTTLNWSQYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELIEAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGYAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALDMGLINAITKIEELEAQGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTKEAQEGRDSFLEKRSPDFSDYKWTP
>Mature_285_residues
MKVLPGKTTLNWSQYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELIEAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGYAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALDMGLINAITKIEELEAQGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTKEAQEGRDSFLEKRSPDFSDYKWTP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=281, Percent_Identity=29.1814946619217, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=26.8774703557312, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4502327, Length=276, Percent_Identity=28.6231884057971, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=271, Percent_Identity=59.7785977859779, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1787659, Length=254, Percent_Identity=27.9527559055118, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=26.1538461538462, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=29.5880149812734, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=28.6792452830189, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=266, Percent_Identity=29.6992481203008, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=27.1653543307087, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=29.7169811320755, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=209, Percent_Identity=29.1866028708134, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=183, Percent_Identity=30.0546448087432, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=281, Percent_Identity=23.4875444839858, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24653139, Length=281, Percent_Identity=30.2491103202847, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI20129971, Length=276, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653477, Length=276, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21357171, Length=193, Percent_Identity=33.160621761658, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24654903, Length=208, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650670, Length=252, Percent_Identity=26.5873015873016, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31750; Mature: 31750

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLPGKTTLNWSQYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELIEAFNIVR
CCCCCCCCCCCHHHHCCHHHHHEECCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHC
NDETIGVVLFTGAGPDKKGIYSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPK
CCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIALVPGYAIGGGQVLHLICDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCEECCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEALDMGLINAITKIEELEAQGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSTKEAQEGRDSFLEKRSPDFSDYKWTP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKVLPGKTTLNWSQYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELIEAFNIVR
CCCCCCCCCCCHHHHCCHHHHHEECCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHC
NDETIGVVLFTGAGPDKKGIYSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPK
CCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIALVPGYAIGGGQVLHLICDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCEECCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEALDMGLINAITKIEELEAQGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSTKEAQEGRDSFLEKRSPDFSDYKWTP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]