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The map label for this gene is thrS

Identifier: 78778982

GI number: 78778982

Start: 560970

End: 562886

Strand: Reverse

Name: thrS

Synonym: PMT9312_0597

Alternate gene names: 78778982

Gene position: 562886-560970 (Counterclockwise)

Preceding gene: 78778983

Following gene: 78778981

Centisome position: 32.93

GC content: 32.13

Gene sequence:

>1917_bases
ATGCCAATAATTACCTTGCCTGATGGTTCAAAAAAGGTTTTCGAAAAATCTGTAACTATTCTAGAAATTGCCCAGAGTAT
AGGTGCTGGATTAGCTAAAGCAACAATTGCTGGGAAAGTAAATGATGTCCTTATAGATGCAACGCTCCCTATAAAAAATG
ATTCCAAAGTTGTAATCATTACATCAAAAGATAAAGAAGGAATTGAAATAATAAGACATTCCTTTGCTCACCTTATTGGT
CATGCAGTTAAACAAATTTACTCTGATATTAAAATGGCAATTGGGCCTGTAATTGAGGATGGTTTTTATTACGATATTTT
TTCTGAACAAAGATTTACTCCTGAAGATTTAATAAAAATCGAAAATAGAATAAATAAATTAATAAAAACGAACTATGACG
TTGAAATTTTACAAGTTTCTAAAGAAGAGGCAATTAAAACTTTTAAGGAAAGAGATGAGACTTTTAAATTACGAATAATT
GAAGAAATTCCTGAAGAAGGTCTCATCAATTTATACAAGCACGAAGAATATATCGACATGTGTAGAGGGCCTCACGTACC
CAACACAAGACATTTGAGACACTTTAAGTTACTTAAATTATCAGGCTCATACTGGAGAGGTAATAGTGAGAATGAAGCAT
TACAGAGAATATATGGAACTGCATGGGCTAAAGAAAAAGAACTCAAAGATTATTTAACAAGAATTGAAGAGGCGGAAAAA
AGAGATCATAGAAAACTTGGAAAAAAACATTCACTTTTTCATATTCAAGAAGAATCTCCAGGAATGATTTTTTGGCATCC
AAATGGATGGACAATCTACCAAGTGCTTGAAAAATACATAAGAGAAATACTTAAAAAAAATGATTATTTAGAAATCAAAA
CACCACAAGCTGTTGATAAATCTCTCTGGGAAAAATCCGGTCATTGGGAAAAATTTAGAGACGATATGTTTACTACTGCG
TCAGAAAATCGAACATATGCAATAAAACCAATGAATTGTCCATGCCATATTCAATTATTTAATCAAGGTTTAAAAAGTTA
TAAGGATTTACCTATTCGTCTTGCTGAATTTGGTTCTTGTCACAGAAATGAGCCCTCTGGTGCACTGCACGGCTTAATGA
GAGTAAGAAACTTTACTCAAGATGATGCGCACATATTTTGCAAAGAAGAGCAGATTCAAGAAGAGGTGTCCACATTTATA
GATCTTGTTTTCGAGGTTTATAAAACTTTTGGTTTTGATGAAATAATTATCAAATTATCAACCCGTCCTGAAAAAAGGGT
AGGTAGTGAAGAGATTTGGGATAAATCAGAAGAGGCCCTTACCAAAGCTCTCGATAATAAGAATCTAAAATGGGAACTCC
AACCTGGAGAAGGTGCTTTTTATGGTCCAAAAATAGAATTCTCGTTAAAAGATTGTCTTAATAGAGTCTGGCAGTGCGGA
ACCATTCAGGTTGATTTTTCAATGCCTATTAGATTGGAAGCAACTTATGTAGATATTGATAATGAAAAAAGAAATCCAGT
TATGCTTCATAGGGCAATTTTAGGATCCTTTGAAAGATTTATCGGAATCTTAATTGAACAATATGAGGCGAAATTTCCGA
TTTGGCTTGCTCCTTATCAAATAATTTTGTTGAGTATTACCGATAGAAATAATGAAAAGTGTTTAAAATTTAATGAATTA
ATAAATAATAATGGTTACCGATCAAAAGTTGATATTAGGAATGAAAAGATAGGATACAAAATAAGGGAGGCAACTATAAG
TAGAATTCCCTTAATTGCAGTAATAGGTGATAAAGAAGAGGAAATTGATTCAGTAGCTCTAAGAGCTTTGGATGGAACAA
ATTTAGGAATTTTCAATTTACCTAATCTCTATAAATTAATGGATGAATTAATAGATAAAAAAGGTCGAACGGAATAA

Upstream 100 bases:

>100_bases
CATCCTTGATGAAGGGAAGGAAAAAGCTGAAGATTTAGCAAATCAGACTTTAAAAAGAGTTAAATCAAAATTGGGATTCT
TTGAAATGGAGAAATAAATT

Downstream 100 bases:

>100_bases
TTTCAAATTTATGAATTTTCTGGCTTGTGATTTAGGAGGTACCAAGGTTCTTTTGGGAATATTTAAAAAAGATATAAATG
ATGATTCACCTAAGTTAATA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLIDATLPIKNDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEQRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENEALQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQLFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCKEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPIRLEATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNNEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATISRIPLIAVIGDKEEEIDSVALRALDGTNLGIFNLPNLYKLMDELIDKKGRTE

Sequences:

>Translated_638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLIDATLPIKNDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEQRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENEALQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQLFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCKEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPIRLEATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNNEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATISRIPLIAVIGDKEEEIDSVALRALDGTNLGIFNLPNLYKLMDELIDKKGRTE
>Mature_637_residues
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLIDATLPIKNDSKVVIITSKDKEGIEIIRHSFAHLIGH
AVKQIYSDIKMAIGPVIEDGFYYDIFSEQRFTPEDLIKIENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIE
EIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENEALQRIYGTAWAKEKELKDYLTRIEEAEKR
DHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTAS
ENRTYAIKPMNCPCHIQLFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCKEEQIQEEVSTFID
LVFEVYKTFGFDEIIIKLSTRPEKRVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCGT
IQVDFSMPIRLEATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNNEKCLKFNELI
NNNGYRSKVDIRNEKIGYKIREATISRIPLIAVIGDKEEEIDSVALRALDGTNLGIFNLPNLYKLMDELIDKKGRTE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=612, Percent_Identity=40.6862745098039, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI38570111, Length=597, Percent_Identity=41.2060301507538, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI20070344, Length=652, Percent_Identity=35.1226993865031, Blast_Score=408, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=621, Percent_Identity=58.6151368760064, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=24.8447204968944, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71984184, Length=648, Percent_Identity=40.1234567901235, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71984192, Length=629, Percent_Identity=40.8585055643879, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=36.7834394904459, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=37.5314861460957, Blast_Score=293, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24583842, Length=639, Percent_Identity=38.4976525821596, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI28574141, Length=639, Percent_Identity=38.4976525821596, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583839, Length=639, Percent_Identity=38.4976525821596, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74094; Mature: 73963

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLIDATLPIKNDSKVVII
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEQRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
ENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENEALQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQLFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCKEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCCCCCCHHHHCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLEATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNNEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATISRIPLIAVIGDKEE
EEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHCCEEEEECCCHH
EIDSVALRALDGTNLGIFNLPNLYKLMDELIDKKGRTE
HHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLIDATLPIKNDSKVVII
CEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEQRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
ENRINKLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENEALQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQLFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCKEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEEIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCCCCCCHHHHCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLEATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNNEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATISRIPLIAVIGDKEE
EEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHCCEEEEECCCHH
EIDSVALRALDGTNLGIFNLPNLYKLMDELIDKKGRTE
HHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA