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The map label for this gene is pyrC [H]

Identifier: 78778954

GI number: 78778954

Start: 531569

End: 532618

Strand: Direct

Name: pyrC [H]

Synonym: PMT9312_0569

Alternate gene names: 78778954

Gene position: 531569-532618 (Clockwise)

Preceding gene: 78778952

Following gene: 78778955

Centisome position: 31.1

GC content: 31.14

Gene sequence:

>1050_bases
TTGAAGACATTAACCATAATAAAACCTGATGATTGGCATTTACATTTAAGAGAAGGTCTTGTATTAAAAAATATCATTCA
TTTTACTTCAGAATTTTTTGGAAGAGCTATCGTTATGCCAAATACTAAAATTCCCATAACAACTATTGATGGCGCTATTT
CTTACAAAAAATCTATTGTTGAAGCGTTACCAGAAAGTTCTAAGTTTGAACCATTAATGACAATGTATCTTACAGATGAG
ACTGATAAAGGAGAACTAATAAATGGTTTCAAAAATAATGTTTTTTTCGCAGCAAAATTATATCCTGCTAATGCCACAAC
AAATTCCATTCATGGAGTTAAGAAAATAAAAAATCTATATAAGATCTTTGAATCAATGCAAGATTCTGGAATGCCTCTTC
TAATTCATGGGGAAGTGACTGATTCTGAAGTGGATGTATTTGATAGAGAAGAAGTTTTTATAGATAGAGAACTTTCCCAA
ATAACTAAAAGATTTCCAAAATTAAAAATCGTTTTAGAACATATAACCACCTCTTATGCAGTGGATTTTGTTCAAGAAAA
TAATATTGGAGCTACTATCACTCCCCATCATTTGCACATAAATAGAAATGCAATGTTTTTTGGAGGCTTAAATAGTGATT
TTTACTGCTTACCTGTGGCTAAGAGGGAAAAAAATAGACTGGCTTTGAGGAAAGCTGCAACAAGTGGGAAAGAATGTTTT
TTCTTGGGAACTGACTCTGCTCCACACCTAAGAAAGTGGAAGGCTTTTTGTGGTTGTGCAGGTATTTTTAATTCGCCAGT
AGCAATAGAAAGCTATTTAACTGTATTTGAAGAGGAAAATGCTCTAGATAATTTTGAGAAGTTTGCAAGTTTGAATGGCT
CTGATTTTTATAATTTGCACCCAAATAAAGAAAAATTAAAATTAGTGTCTAAACCTAATAAAATTAAAGAATATATTGAT
GTTGTTGAAGAAAAAAATATTGTCGGACAAATAAAACCATTTCATGCAGGTGAAACTTTACAATGGCATGTAGAAGGGAT
TGTAAATTAA

Upstream 100 bases:

>100_bases
ATAATTAAAATTTTAATAATTGATTAATAACTATCCTCGAATATCTATAATTTATTGTCAATTTTAATTTGCTGTTAAAA
TTGATTAAATAGTAAAAATT

Downstream 100 bases:

>100_bases
CAAATTAAAGTTAATCTGATCATTCATTAAAAGTGTAAATTTCCCAATTTTTATTGGTTAAATGGGTTGCTTTCGGCTAC
GATAAATAAGCGCAAATTCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEFFGRAIVMPNTKIPITTIDGAISYKKSIVEALPESSKFEPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSIHGVKKIKNLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDRELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKREKNRLALRKAATSGKECF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEENALDNFEKFASLNGSDFYNLHPNKEKLKLVSKPNKIKEYID
VVEEKNIVGQIKPFHAGETLQWHVEGIVN

Sequences:

>Translated_349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEFFGRAIVMPNTKIPITTIDGAISYKKSIVEALPESSKFEPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSIHGVKKIKNLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDRELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKREKNRLALRKAATSGKECF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEENALDNFEKFASLNGSDFYNLHPNKEKLKLVSKPNKIKEYID
VVEEKNIVGQIKPFHAGETLQWHVEGIVN
>Mature_349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEFFGRAIVMPNTKIPITTIDGAISYKKSIVEALPESSKFEPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSIHGVKKIKNLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDRELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKREKNRLALRKAATSGKECF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEENALDNFEKFASLNGSDFYNLHPNKEKLKLVSKPNKIKEYID
VVEEKNIVGQIKPFHAGETLQWHVEGIVN

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=50.1440922190202, Blast_Score=360, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=34.2618384401114, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39646; Mature: 39646

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEFFGRAIVMPNTKIPITTIDGAISYKKSIV
CCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHH
EALPESSKFEPLMTMYLTDETDKGELINGFKNNVFFAAKLYPANATTNSIHGVKKIKNLY
HHCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
KIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDRELSQITKRFPKLKIVLEHITTSYA
HHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHEHHHHHHHHHHCCHHHHHHHHHHHHHH
VDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKREKNRLALRKAATSGKECF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEENALDNFEKFASLNGSDFYNLH
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEC
PNKEKLKLVSKPNKIKEYIDVVEEKNIVGQIKPFHAGETLQWHVEGIVN
CCHHHHEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEFFGRAIVMPNTKIPITTIDGAISYKKSIV
CCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHH
EALPESSKFEPLMTMYLTDETDKGELINGFKNNVFFAAKLYPANATTNSIHGVKKIKNLY
HHCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
KIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDRELSQITKRFPKLKIVLEHITTSYA
HHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHEHHHHHHHHHHCCHHHHHHHHHHHHHH
VDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKREKNRLALRKAATSGKECF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEENALDNFEKFASLNGSDFYNLH
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEC
PNKEKLKLVSKPNKIKEYIDVVEEKNIVGQIKPFHAGETLQWHVEGIVN
CCHHHHEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA