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The map label for this gene is gor [H]

Identifier: 78778952

GI number: 78778952

Start: 528989

End: 530368

Strand: Direct

Name: gor [H]

Synonym: PMT9312_0567

Alternate gene names: 78778952

Gene position: 528989-530368 (Clockwise)

Preceding gene: 78778950

Following gene: 78778954

Centisome position: 30.95

GC content: 31.16

Gene sequence:

>1380_bases
TTGATTAAAAAAATCTTGGAATTTCAATTTGATTTGATTGTTGTTGGCGCTGGATCTGGAGGACTGGCGGCGGCTAAACG
TGCTGCTAGTTATGGCGCAAAAGTTGCAATCATAGAAGTAAATAAAATAGGAGGAACTTGTGTAATAAGGGGATGTGTTC
CTAAGAAATTGATGGTTTATGCAGCTAAAAGTAAAAAAAATATGGATTCTTCTGAAGGATATGGATTAAAAAGTGAAGGT
ATTAGTTTTGAATCAGATATTTTATTGAAGAATGTTAGAGAGGAGGTTTCCAGATTAAGTGATTTACATAGAAATTCTTT
AAATAAACTAGATGTAACTGTTTTTGAGGGCTTAGGAAGATTCACTGCTCAAAATGAATTAGAAATAATTTGTCCAAAAA
CAAAGAAAATTATAAATAAAATTAGCTCAAAAAAAATTCTTATTTCAGTTGGAGGTAAACCAAAGAAATTGAATATCCCA
GGAATGGATTTGGCATGGACTAGTGACGATATTTTTGAGTTAGAAAATTTTCCTAAATCAATTTTAATAGTGGGTGGAGG
ATATATTGCCTGCGAATTTGCTTCTATTTTCAGGAATTTAGGTACTGAAGTAACTCAATTAATAAGAGGTCAACGTTTAC
TTAATGGTTTTGATGAAGATCTGTCTTCATGCTTAGAAGAATCACCTACTTTTACTGGAATAAATATCATCTTCAATACT
CAATTAAAGTCTATCAGGAGAGTAAATGGGAATCTGGAATCTACTTTGGATTCCGGTGAGAAAATTTTAACTAATAATAT
CCTTATTGCTACAGGTAGAGAACCAAATCTTATCCCTTTAAATTTAGATTTTTTAAATCTAAAGATGGATGGCCAATATT
TAGATGTTAATGAACTTAATCAAACAAGCAACGCTAATATTTTTGCAGTTGGCGATATCATAAACAGACCAAATTTAACT
CCAGTAGCAATTGAACAAGGTAGAGTCTTTTCGGATAATTTCTTTAATGACCAAAAAAGAAAAGTAAATTATGAAAATAT
CCCGAAGGCAGTTTTCACTATACCAGAAATTTCAACAGTTGGTTTAAGCGAGAAAAGAGCGAAAGAGGTTTACTCTGAGA
AAAATATAAAAATTTTCAAATGTAAATTTACGCCTATGTCTAATACTTTTAAAGAGAAAAAAACAAAATGTATGTTGAAG
ATTGTAGTTAATTCAATAACTGATAAAGTACTGGGATGCCATATGTTTGGAGAAACATCATCTGAGATTATTCAAATGGT
ATCAATTGCATTAAACGCAGGTATAACAAAAAAAGACTTTGATACTACTATGGCTTTGCACCCAACTATCTCAGAAGAAT
TTGTGACAATGTATGGCTAA

Upstream 100 bases:

>100_bases
TGACTCTATCAAGATCTTCAACTTTATATTTATTTAAATCTTCCCATGTCAAAATATCATTCATTCTTTGAATTAAGGCT
ATAAACTAACTTTATAATAA

Downstream 100 bases:

>100_bases
AATTATGATTCAGAAAATTTTAAATTTTCTTGAGCAAATAGAATTACTACAAGTAATGAAAAGTAAAAAATTAAACCTAT
CCTTAATTCAGAAAGATAAT

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MIKKILEFQFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKSEG
ISFESDILLKNVREEVSRLSDLHRNSLNKLDVTVFEGLGRFTAQNELEIICPKTKKIINKISSKKILISVGGKPKKLNIP
GMDLAWTSDDIFELENFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQRLLNGFDEDLSSCLEESPTFTGINIIFNT
QLKSIRRVNGNLESTLDSGEKILTNNILIATGREPNLIPLNLDFLNLKMDGQYLDVNELNQTSNANIFAVGDIINRPNLT
PVAIEQGRVFSDNFFNDQKRKVNYENIPKAVFTIPEISTVGLSEKRAKEVYSEKNIKIFKCKFTPMSNTFKEKKTKCMLK
IVVNSITDKVLGCHMFGETSSEIIQMVSIALNAGITKKDFDTTMALHPTISEEFVTMYG

Sequences:

>Translated_459_residues
MIKKILEFQFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKSEG
ISFESDILLKNVREEVSRLSDLHRNSLNKLDVTVFEGLGRFTAQNELEIICPKTKKIINKISSKKILISVGGKPKKLNIP
GMDLAWTSDDIFELENFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQRLLNGFDEDLSSCLEESPTFTGINIIFNT
QLKSIRRVNGNLESTLDSGEKILTNNILIATGREPNLIPLNLDFLNLKMDGQYLDVNELNQTSNANIFAVGDIINRPNLT
PVAIEQGRVFSDNFFNDQKRKVNYENIPKAVFTIPEISTVGLSEKRAKEVYSEKNIKIFKCKFTPMSNTFKEKKTKCMLK
IVVNSITDKVLGCHMFGETSSEIIQMVSIALNAGITKKDFDTTMALHPTISEEFVTMYG
>Mature_459_residues
MIKKILEFQFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKSEG
ISFESDILLKNVREEVSRLSDLHRNSLNKLDVTVFEGLGRFTAQNELEIICPKTKKIINKISSKKILISVGGKPKKLNIP
GMDLAWTSDDIFELENFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQRLLNGFDEDLSSCLEESPTFTGINIIFNT
QLKSIRRVNGNLESTLDSGEKILTNNILIATGREPNLIPLNLDFLNLKMDGQYLDVNELNQTSNANIFAVGDIINRPNLT
PVAIEQGRVFSDNFFNDQKRKVNYENIPKAVFTIPEISTVGLSEKRAKEVYSEKNIKIFKCKFTPMSNTFKEKKTKCMLK
IVVNSITDKVLGCHMFGETSSEIIQMVSIALNAGITKKDFDTTMALHPTISEEFVTMYG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=36.7965367965368, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=31.2910284463895, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=31.2910284463895, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=31.2910284463895, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=31.2910284463895, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=31.2910284463895, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI291045266, Length=482, Percent_Identity=30.4979253112033, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=30.1310043668122, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=27.2727272727273, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI291045268, Length=482, Percent_Identity=27.5933609958506, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=35.1724137931034, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=28.0087527352298, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=27.5862068965517, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=25.382932166302, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=35.531914893617, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=36.5800865800866, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=36.5800865800866, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=32.4380165289256, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=26.8980477223427, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=36.3247863247863, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=25.8547008547009, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=24.0343347639485, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=33.7552742616034, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=32.484076433121, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=32.484076433121, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=32.4267782426778, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=27.9569892473118, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50799; Mature: 50799

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKILEFQFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVIRGCVPKKLMVY
CCHHHHCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEEE
AAKSKKNMDSSEGYGLKSEGISFESDILLKNVREEVSRLSDLHRNSLNKLDVTVFEGLGR
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
FTAQNELEIICPKTKKIINKISSKKILISVGGKPKKLNIPGMDLAWTSDDIFELENFPKS
CCCCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCEECCCCCEEEECCCCHHHHHCCCCE
ILIVGGGYIACEFASIFRNLGTEVTQLIRGQRLLNGFDEDLSSCLEESPTFTGINIIFNT
EEEEECCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
QLKSIRRVNGNLESTLDSGEKILTNNILIATGREPNLIPLNLDFLNLKMDGQYLDVNELN
HHHHHHHHCCCHHHHHCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCC
QTSNANIFAVGDIINRPNLTPVAIEQGRVFSDNFFNDQKRKVNYENIPKAVFTIPEISTV
CCCCCCEEEEECCCCCCCCCEEEEECCCEECCCCCCCHHHCCCHHHCCCEEEECCCCEEC
GLSEKRAKEVYSEKNIKIFKCKFTPMSNTFKEKKTKCMLKIVVNSITDKVLGCHMFGETS
CCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCH
SEIIQMVSIALNAGITKKDFDTTMALHPTISEEFVTMYG
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHEECC
>Mature Secondary Structure
MIKKILEFQFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVIRGCVPKKLMVY
CCHHHHCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEEE
AAKSKKNMDSSEGYGLKSEGISFESDILLKNVREEVSRLSDLHRNSLNKLDVTVFEGLGR
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
FTAQNELEIICPKTKKIINKISSKKILISVGGKPKKLNIPGMDLAWTSDDIFELENFPKS
CCCCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCEECCCCCEEEECCCCHHHHHCCCCE
ILIVGGGYIACEFASIFRNLGTEVTQLIRGQRLLNGFDEDLSSCLEESPTFTGINIIFNT
EEEEECCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
QLKSIRRVNGNLESTLDSGEKILTNNILIATGREPNLIPLNLDFLNLKMDGQYLDVNELN
HHHHHHHHCCCHHHHHCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCC
QTSNANIFAVGDIINRPNLTPVAIEQGRVFSDNFFNDQKRKVNYENIPKAVFTIPEISTV
CCCCCCEEEEECCCCCCCCCEEEEECCCEECCCCCCCHHHCCCHHHCCCEEEECCCCEEC
GLSEKRAKEVYSEKNIKIFKCKFTPMSNTFKEKKTKCMLKIVVNSITDKVLGCHMFGETS
CCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCH
SEIIQMVSIALNAGITKKDFDTTMALHPTISEEFVTMYG
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]