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The map label for this gene is hemH

Identifier: 78778910

GI number: 78778910

Start: 490844

End: 492019

Strand: Direct

Name: hemH

Synonym: PMT9312_0525

Alternate gene names: 78778910

Gene position: 490844-492019 (Clockwise)

Preceding gene: 78778904

Following gene: 78778911

Centisome position: 28.72

GC content: 36.31

Gene sequence:

>1176_bases
ATGAATAAAATAGGCGTCTTGCTAATGAATTTAGGGGGGCCTGAACGCATTACCGATGTCGGCCCATTCTTATATAATCT
TTTTTCTGATCCAGAGATAATCAGGACTCCTTTTCCTGCTTTTCAAAAACCTTTAGCTTGGTTAATTAGTACGCTTAGAA
GTACCACTTCACAACAAGCTTATCTTTCTATAGGTGGAGGATCACCCATTAGAAGGATAACTGAACAACAAGCAAGAGAA
TTGCAATCTAAATTAAGGGAGAAAGGTTTAAATGCTACTACTTATATCGCTATGAGGTATTGGCATCCTTTTACGGAATC
AGCAATTGCTGATATGAAAGCAGATTGTGTAGATCAAATTGTTGTACTACCTTTGTATCCACATTTTTCAATAAGTACAA
GTGGTTCAAGCTTTAGGGAATTAAAAAAATTAAGAGATTCCGATAATGATTTTAAGAAAATCCCAATGCGATGTGTAAGA
AGTTGGTTCAGTCAATCAGGTTATTTAAAGTCAATGGTCGAATTAATTTCCCAACAAATTTCCTGTTGTGAATCACCTCC
AAATGCACATATATTTTTTACTGCTCATGGAGTTCCCAAGAGTTATGTAGAGGAAGCTGGAGACCCTTATAAACAACAAA
TTGAAGATTGTTCCTTATTGATAATTAATGAGCTGGAAAAATATTTAGGGCACAGTAACCCGCATACACTTTCTTACCAA
AGTAGAGTTGGTCCAGTTGAATGGTTGAAACCTTACACCGAAGAAGTGTTAGCAGATCTTGGGAAGTCTAATGTTGAAGA
TCTTATTGTGGTTCCAATAAGTTTCGTTGGAGAGCATATTGAAACATTGCAAGAAATTGACATTGAATATAAAGAAATTG
CCGAAAAAGCTGGTATTAAAAACTTTCGTAGAGTGAAGGCTCTAAATACTCATCCTACTTTTATTGAGGGTCTTAGTGAT
TTAGTAATTTCTTGCCTGGAAGAGCCTCAAGTTAATATAGAGGAGGCTTCTAAGTTACCTGAAAAAGTTAAACTTTATCC
CCAAGAGAAATGGCAATGGGGTTGGAATAATAGTTCAGAGGTGTGGAATGGGAGAGTTGCCATGATCGTTTTTCTGGTAC
TTTTTATAGAACTAATTGCAGGCTCTGGACCCTTACATAGGCTTGGGATTTTATGA

Upstream 100 bases:

>100_bases
TCATTGACATTATTAATTTCCTGAATTACGTTCATTTACTTCTATAATTGACCTTATAATGACGTTTTTAATGTTGATTT
TCAATCACCATAAATTTTAA

Downstream 100 bases:

>100_bases
AAATTAATTTATGTTTATTTGAAAAATTTTAAATTTATTGAAATTTCTTTTGAATACTTTTCTGACATTACATTTCTAAA
TGAGGCAAAAGTATTTAATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGLNATTYIAMRYWHPFTESAIADMKADCVDQIVVLPLYPHFSISTSGSSFRELKKLRDSDNDFKKIPMRCVR
SWFSQSGYLKSMVELISQQISCCESPPNAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKYLGHSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGKSNVEDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEEPQVNIEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLVLFIELIAGSGPLHRLGIL

Sequences:

>Translated_391_residues
MNKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGLNATTYIAMRYWHPFTESAIADMKADCVDQIVVLPLYPHFSISTSGSSFRELKKLRDSDNDFKKIPMRCVR
SWFSQSGYLKSMVELISQQISCCESPPNAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKYLGHSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGKSNVEDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEEPQVNIEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLVLFIELIAGSGPLHRLGIL
>Mature_391_residues
MNKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGLNATTYIAMRYWHPFTESAIADMKADCVDQIVVLPLYPHFSISTSGSSFRELKKLRDSDNDFKKIPMRCVR
SWFSQSGYLKSMVELISQQISCCESPPNAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKYLGHSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGKSNVEDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEEPQVNIEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLVLFIELIAGSGPLHRLGIL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=34.441087613293, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=34.441087613293, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=31.7073170731707, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=335, Percent_Identity=36.4179104477612, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=33.4328358208955, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45552018, Length=142, Percent_Identity=40.8450704225352, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44332; Mature: 44332

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPAFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLREKGLNATTYIAMRYWHPFTESAIADMKADCVDQI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHHHHHHHHE
VVLPLYPHFSISTSGSSFRELKKLRDSDNDFKKIPMRCVRSWFSQSGYLKSMVELISQQI
EHEECCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SCCESPPNAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKYLGHSNPHTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
SRVGPVEWLKPYTEEVLADLGKSNVEDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCHH
NFRRVKALNTHPTFIEGLSDLVISCLEEPQVNIEEASKLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLVLFIELIAGSGPLHRLGIL
HHCCHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MNKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPAFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLREKGLNATTYIAMRYWHPFTESAIADMKADCVDQI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHHHHHHHHE
VVLPLYPHFSISTSGSSFRELKKLRDSDNDFKKIPMRCVRSWFSQSGYLKSMVELISQQI
EHEECCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SCCESPPNAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKYLGHSNPHTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
SRVGPVEWLKPYTEEVLADLGKSNVEDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCHH
NFRRVKALNTHPTFIEGLSDLVISCLEEPQVNIEEASKLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLVLFIELIAGSGPLHRLGIL
HHCCHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA