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The map label for this gene is hemL

Identifier: 78778869

GI number: 78778869

Start: 452440

End: 453744

Strand: Reverse

Name: hemL

Synonym: PMT9312_0484

Alternate gene names: 78778869

Gene position: 453744-452440 (Counterclockwise)

Preceding gene: 78778870

Following gene: 78778863

Centisome position: 26.55

GC content: 40.38

Gene sequence:

>1305_bases
GTGACTGACATATTAAATTGCACCAAATCAGAAGAAATCTTTTCTGCTGCCCAAGAATTAATGCCTGGGGGAGTAAGTTC
CCCAGTAAGAGCTTTTAAATCCGTCGGAGGTCAGCCGATTGTTTTTGATAGAGTTAAAGGCCCTTTTGCTTGGGATATTG
ATGGAAATAGATATATTGACTACATAGGAAGTTGGGGGCCCGCTATATGTGGACATGCGCATCCCGAAGTTACAACTGCA
CTACAGGAAGCAATTGAGAAAGGGACCAGTTTTGGAGCTCCTTGCGTTTTAGAGAACAAACTTGCTGAGATGGTTATAGA
TGCTGTCCCATCTGTAGAAATGGTTAGATTTGTTAATAGTGGAACTGAAGCCTGCATGGCTGTTTTGAGGCTTATGAGAG
CATTCACTGGGAGAGATAAAGTTATTAAATTCGACGGTTGCTATCACGGTCATGCAGACATGTTTTTAGTGAAAGCCGGA
TCAGGTGTGGCCACTTTAGGTTTACCAGATTCCCCAGGGGTGCCACGAACAACAACTGCAAATACACTAACTGCTCCCTA
CAATGATCTTGAAGCAGTTAAAAAATTATTTTCAGAAAATCCTGATGCCATTTCGGGGGTCATTCTTGAGCCTATTGTTG
GTAATGCTGGCTTTATTACTCCTGAACCTGGATTCTTAGAAGGATTAAGGGAATTAACCACTGAGAATGGATCCTTATTA
GTTTTTGATGAAGTCATGACTGGATTCAGAATCAGTTATGGAGGCGCACAAGAAAAATTTGGTGTTACTCCTGATTTAAC
TACACTTGGAAAGGTAATTGGAGGCGGCTTACCTGTCGGAGCTTATGGAGGTAAGAAAGAAATAATGTCAATGGTAGCTC
CTTCAGGACCGGTCTACCAGGCAGGTACTTTGAGCGGAAACCCACTTGCAATGACTGCTGGTATAAAGACTCTTGAACTA
CTTAAACAAGAAGGTACCTATGAGAAACTAGATGCAATAACTTCTAGATTAATTGAAGGGATAATTCAGTCTGCCGAAAA
TAATGGTATTGCTATTTACGGTGGAAGTGTAAGTGCTATGTTTGGTTTTTTCTTATGTGATGGGCCAGTTAGGAACTTTG
ATGAAGCAAAAACAAATGATGCTAAACTTTTTGGAAAGTTACATAGAGAGATGCTTCGAAGAGGTGTTTATCTTGCACCA
AGTCCATTTGAGGCTGGCTTCACATCACTCGCTCATAACGAAGAAGAAATTGATAAAACAATCGAGGTATTTGATCAATG
CTTTAATACTATAAAAAACCAATAA

Upstream 100 bases:

>100_bases
AATATCATAATGTAGAATTTCAATCTCATTGACAAAATTTTTACTTATTTCTAACTTAGAACATGACAAGATTTTTATCA
AAGCATTATTTAGTTAAATT

Downstream 100 bases:

>100_bases
CTAGTTTGTTTTTTAAAGAAAATCAAACTAGTTAGATTTTAGGTAGGAGATAATTTAAATTAATTACCTTCTACCACCAA
CAATTACTGGTGGGGTGCCT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTDILNCTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTA
LQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLEL
LKQEGTYEKLDAITSRLIEGIIQSAENNGIAIYGGSVSAMFGFFLCDGPVRNFDEAKTNDAKLFGKLHREMLRRGVYLAP
SPFEAGFTSLAHNEEEIDKTIEVFDQCFNTIKNQ

Sequences:

>Translated_434_residues
MTDILNCTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTA
LQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLEL
LKQEGTYEKLDAITSRLIEGIIQSAENNGIAIYGGSVSAMFGFFLCDGPVRNFDEAKTNDAKLFGKLHREMLRRGVYLAP
SPFEAGFTSLAHNEEEIDKTIEVFDQCFNTIKNQ
>Mature_433_residues
TDILNCTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTAL
QEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGS
GVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLLV
FDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLELL
KQEGTYEKLDAITSRLIEGIIQSAENNGIAIYGGSVSAMFGFFLCDGPVRNFDEAKTNDAKLFGKLHREMLRRGVYLAPS
PFEAGFTSLAHNEEEIDKTIEVFDQCFNTIKNQ

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=28.992628992629, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=26.4094955489614, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI37574042, Length=308, Percent_Identity=27.9220779220779, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24119277, Length=334, Percent_Identity=26.3473053892216, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442705, Length=307, Percent_Identity=27.3615635179153, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI284507298, Length=252, Percent_Identity=31.3492063492063, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442709, Length=276, Percent_Identity=27.8985507246377, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=53.5545023696682, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=29.6385542168675, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1788044, Length=355, Percent_Identity=34.6478873239437, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789759, Length=307, Percent_Identity=32.2475570032573, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI145693181, Length=306, Percent_Identity=31.0457516339869, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787560, Length=309, Percent_Identity=29.126213592233, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786991, Length=320, Percent_Identity=25.625, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=300, Percent_Identity=29, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=330, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=147, Percent_Identity=34.6938775510204, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=26.303317535545, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=352, Percent_Identity=24.7159090909091, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161085790, Length=345, Percent_Identity=26.3768115942029, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357415, Length=300, Percent_Identity=26.3333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574759, Length=345, Percent_Identity=26.3768115942029, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356575, Length=326, Percent_Identity=28.5276073619632, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_PROM9 (Q31C50)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_396981.1
- ProteinModelPortal:   Q31C50
- SMR:   Q31C50
- STRING:   Q31C50
- GeneID:   3765283
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0484
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- ProtClustDB:   PRK00062
- BioCyc:   PMAR74546:PMT9312_0484-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46419; Mature: 46287

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILNCTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVTTALQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQ
EEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQEGTYEKLDAITSRLIEGIIQSAENNGIAIYGGSVSAM
CCCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFDEAKTNDAKLFGKLHREMLRRGVYLAPSPFEAGFTSLAHNEEEIDKT
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCHHHHHHH
IEVFDQCFNTIKNQ
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TDILNCTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVTTALQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQ
EEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQEGTYEKLDAITSRLIEGIIQSAENNGIAIYGGSVSAM
CCCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFDEAKTNDAKLFGKLHREMLRRGVYLAPSPFEAGFTSLAHNEEEIDKT
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCHHHHHHH
IEVFDQCFNTIKNQ
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA