Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 78778836

GI number: 78778836

Start: 426322

End: 428076

Strand: Reverse

Name: groEL

Synonym: PMT9312_0451

Alternate gene names: 78778836

Gene position: 428076-426322 (Counterclockwise)

Preceding gene: 78778838

Following gene: 78778830

Centisome position: 25.05

GC content: 37.15

Gene sequence:

>1755_bases
ATGGCTAAACAGTTAAGTTTTTCTAATGAATCAAGAGATGCATTAGAAAAAGGTGTAAATTTTGTAGCTAATGCAGTAAA
GGTTACTATTGGTCCGAAGGCGAAAAACGTAGTAATAGAAAGAAAATTTGGTTCTCCAGATGTAGTAAGAGATGGATCTA
CAGTTGCTAAAGAGATTGAGATTGAAAACCCTATTTCTAATTTAGGAGCGAAGTTAATAGAGCAAGTTGCATCCAAGACA
AAAGAGAGTGCTGGTGATGGAACAACAACTGCAACCATTTTGACTCAGAAGATGGTTCAGGAAGGATTAAAAAATATTGC
TTCAGGTGCTAGTCCCATGGAGTTAAAAAAAGGTATGGAGGTAGGCTTAGCTTTTGTTTTAGAAAAATTAAGTTCTAAAA
GTATTTCATTAAGTGGTTCTGATATCCAAAAAGTTGCAACAGTTAGTGCGGGAGGTGATCAAGAAATTGGATCTATAATT
TCAAAGGCCATGGATATTGTTACTTCGGATGGTGTAATAACTGTTGAAGAATCTCAATCATTAGATACAGAATTAGATAT
AACCGAAGGAATGTCTTTTGATAGAGGATATAGTTCTCCGTATTTTGTAACAGACCAAGAAAGGCAAGTTTGTGAACTTG
AAAACCCAAAAATTTTAATAACTGACCAGAAGATTTCTACGTTAGCTAATTTAGTTCCAATATTAGAAGAAATTCAGAAA
TCAGGATCACCTTTTCTAATTCTCGCTGAAGATATAGAAGGAGAAGCATTAACAACTCTTGTCTTGAATAAGAATAGTGG
AGTTTTGAATGTAGCTTCCGTGAGAGCTCCATTATTTGGTGAGAGAAGAAAAGCTGCCCTTGAAGATATTGCAATTCTTA
CAGGGGCTAAGTTAATTAGCGAAGATAAATCAATGACACTAGATCAAGTATCAATTAATGATTTAGGTAAAGCAAAAAAA
ATAACTATCACAAAGGATAAGACTACTATCGTTGCGTTCGAAGACACTAAAGATTTAGTTAAAGCGCGAGTAGAGAAATT
AAAGAGAGAAGTCGAGATGACAGAATCAGAATATGATCAGGATAAAATTAATGAAAGGATCGCTAAACTTGCTGGAGGTG
TGGCTCTTATAAAAGTAGGAGCTGCAACAGAAACAGAGATGAAGTACAAAAAATTGAGAATAGAAGATTCCCTTAATGCT
ACAAAAGCTGCTATCGAAGAAGGTGTTGTTTCTGGAGGTGGTCAAACTTTAATTGAAATATCAGATGAACTTTTAAATTT
AAGTCAAAAATCATCCGATGATTTGAGAACAGGGATAAATATAGTAAAAGAAGCACTTTTAGAACCTACTAAACAAATAG
CAAAAAATGCTGGTTTTAATGGCGATGTAGTTGTCGCTGAAATTAAGAGGCTTAACAAAGGCTTTAATGCTAATTCAGGA
AAATATGAGAATTTAAAGGAATCAGGGATATTAGACCCAACTAAAGTAATAAGATTAGCTCTTCAAGATTCAGTATCTAT
TGCAGCTATGCTCCTGACAACAGAAGTTGCGATTGCTGACATTCCAGAACCTGAAGCTGCCGCCCCTGGAGGACCAGGTG
GAGATCCTATGGGAGGTATGGGAGGTATGGGAGGCATGGGCATGCCAGGTATGGGAGGCATGGGCATGCCAGGTATGGGA
GGCATGGGCATGCCAGGTATGGGAGGCATGGGCATGCCAGGTATGGGAGGAATGGGCATGCCAGGTATGATGTAA

Upstream 100 bases:

>100_bases
GTATGTCTCATTAAAAGAAATTCGGCTTTCCCCACTTAATTAAATATCCCTTAAAAATGATTCTATGGGAGATTAGAATA
AGAATAAAGAACGAGTAAAC

Downstream 100 bases:

>100_bases
AAAGCTAACTAGCTTTTTTATCTTTATTAATCCACTTTCTTAAATTATTAATATAAGGTAGGGGTAATTTTGGGGTTTTA
GTATATTGATTTGTTTTATT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MAKQLSFSNESRDALEKGVNFVANAVKVTIGPKAKNVVIERKFGSPDVVRDGSTVAKEIEIENPISNLGAKLIEQVASKT
KESAGDGTTTATILTQKMVQEGLKNIASGASPMELKKGMEVGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDQEIGSII
SKAMDIVTSDGVITVEESQSLDTELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLANLVPILEEIQK
SGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDQVSINDLGKAKK
ITITKDKTTIVAFEDTKDLVKARVEKLKREVEMTESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISDELLNLSQKSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIKRLNKGFNANSG
KYENLKESGILDPTKVIRLALQDSVSIAAMLLTTEVAIADIPEPEAAAPGGPGGDPMGGMGGMGGMGMPGMGGMGMPGMG
GMGMPGMGGMGMPGMGGMGMPGMM

Sequences:

>Translated_584_residues
MAKQLSFSNESRDALEKGVNFVANAVKVTIGPKAKNVVIERKFGSPDVVRDGSTVAKEIEIENPISNLGAKLIEQVASKT
KESAGDGTTTATILTQKMVQEGLKNIASGASPMELKKGMEVGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDQEIGSII
SKAMDIVTSDGVITVEESQSLDTELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLANLVPILEEIQK
SGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDQVSINDLGKAKK
ITITKDKTTIVAFEDTKDLVKARVEKLKREVEMTESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISDELLNLSQKSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIKRLNKGFNANSG
KYENLKESGILDPTKVIRLALQDSVSIAAMLLTTEVAIADIPEPEAAAPGGPGGDPMGGMGGMGGMGMPGMGGMGMPGMG
GMGMPGMGGMGMPGMGGMGMPGMM
>Mature_583_residues
AKQLSFSNESRDALEKGVNFVANAVKVTIGPKAKNVVIERKFGSPDVVRDGSTVAKEIEIENPISNLGAKLIEQVASKTK
ESAGDGTTTATILTQKMVQEGLKNIASGASPMELKKGMEVGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDQEIGSIIS
KAMDIVTSDGVITVEESQSLDTELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLANLVPILEEIQKS
GSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDQVSINDLGKAKKI
TITKDKTTIVAFEDTKDLVKARVEKLKREVEMTESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNAT
KAAIEEGVVSGGGQTLIEISDELLNLSQKSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIKRLNKGFNANSGK
YENLKESGILDPTKVIRLALQDSVSIAAMLLTTEVAIADIPEPEAAAPGGPGGDPMGGMGGMGGMGMPGMGGMGMPGMGG
MGMPGMGGMGMPGMGGMGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=42.7221172022684, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=42.7221172022684, Blast_Score=431, Evalue=1e-121,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=48.0151228733459, Blast_Score=505, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17555558, Length=532, Percent_Identity=42.6691729323308, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI193210679, Length=226, Percent_Identity=40.7079646017699, Blast_Score=169, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323288, Length=530, Percent_Identity=43.0188679245283, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=43.289224952741, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=43.289224952741, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=40.9090909090909, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=40.9090909090909, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=40.9090909090909, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=39.9239543726236, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=33.7121212121212, Blast_Score=258, Evalue=9e-69,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=33.7121212121212, Blast_Score=258, Evalue=9e-69,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PROM9 (Q31C83)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_396948.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q31C83
- SMR:   Q31C83
- STRING:   Q31C83
- GeneID:   3765248
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0451
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   GASPIEL
- ProtClustDB:   PRK12849
- BioCyc:   PMAR74546:PMT9312_0451-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 61583; Mature: 61452

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQLSFSNESRDALEKGVNFVANAVKVTIGPKAKNVVIERKFGSPDVVRDGSTVAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHEE
IENPISNLGAKLIEQVASKTKESAGDGTTTATILTQKMVQEGLKNIASGASPMELKKGME
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDQEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEECCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
LDTELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLANLVPILEEIQK
CCCCEEHHCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
SGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EDKSMTLDQVSINDLGKAKKITITKDKTTIVAFEDTKDLVKARVEKLKREVEMTESEYDQ
CCCCCEEEEECHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEEEEH
SDELLNLSQKSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIKRLNKGFNANSG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
KYENLKESGILDPTKVIRLALQDSVSIAAMLLTTEVAIADIPEPEAAAPGGPGGDPMGGM
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
GGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQLSFSNESRDALEKGVNFVANAVKVTIGPKAKNVVIERKFGSPDVVRDGSTVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHEE
IENPISNLGAKLIEQVASKTKESAGDGTTTATILTQKMVQEGLKNIASGASPMELKKGME
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDQEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEECCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
LDTELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLANLVPILEEIQK
CCCCEEHHCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
SGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EDKSMTLDQVSINDLGKAKKITITKDKTTIVAFEDTKDLVKARVEKLKREVEMTESEYDQ
CCCCCEEEEECHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEEEEH
SDELLNLSQKSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIKRLNKGFNANSG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
KYENLKESGILDPTKVIRLALQDSVSIAAMLLTTEVAIADIPEPEAAAPGGPGGDPMGGM
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
GGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA