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The map label for this gene is metC [H]

Identifier: 78778789

GI number: 78778789

Start: 384610

End: 385773

Strand: Reverse

Name: metC [H]

Synonym: PMT9312_0404

Alternate gene names: 78778789

Gene position: 385773-384610 (Counterclockwise)

Preceding gene: 78778790

Following gene: 78778788

Centisome position: 22.57

GC content: 33.93

Gene sequence:

>1164_bases
ATGGGAAATAAGACAAATAATATCAAAAAGCCAGGTGTTAAGACCTTATCTATTCACCATGGGGAAACATTTGCAGAAGA
CACGGGATGCATTATGCCTCCTATTTTTTCTACATCTACTTTCAAGCATGGCAATAAAGAAAGTTTCGACTACACCAGAT
CAGGAAATCCCAACTTTAAAATTCTAGAAAACATACTTAAATCAATAGAAGATTCTAAATACTGTACAGTTTTTGGATCT
GGAATTAGCGCGGTAACTGCAATTACATCAACACTAAAATCAGGCGATAAGATACTCTGCGAATCAAATCTTTATGGTTG
TACAGTGAGGATGTTCGAAAAAATTTTCAAGAAATTTGGGGTAGAAGTTTTATACACAGATTTTACAAATAAAAATAATA
TTAAAAAGATTTCAAACTTCGCGCCAACTTTGATATGGCTAGAAAGTCCAACTAATCCACTTTTAAAGGTGCTTGATATT
AAGGCGATTTGTGATGAAGCGAATAAATTGCAAATACCCGTAGTTGTGGACAACACCTTTTCTACAGCCCTTATTCAAAA
ACCTTTGGAACTTGGCGCAACACTATCGCTTGTAAGCACAACAAAATTCATTAATGGACATAGTGATGCACTTGGTGGAG
CAGTACTTACAAATAATGAGATATGGAATAGTAAGATGCTTTTCTCTCAAAAAGCCCTGGGGCTTCAACCATCTCCTTTT
GATAGTTGGCTCATTACTAGAGGAGTAAAAACCCTTCCTTTAAGAATCGAACAACAAACTCGAAGTGCAGAATTAATTTC
TGAAGAATTAGAGAATCATAAAATAATTAGTAAAGTAATTTATCCTTTTAATCAAAAACACCCGCAATTTAATTTAGCAA
AATCTCAAATGATATCTGGAGGTTCGATGATCACCCTAAAATTAAATTTAAATAAAGAGGATACTTTTAAATTATGCAAG
TCTCTCAAATATTTCTCGCTAGCTGAAAGCCTTGGAGGAGTTGAAAGTTTAATTTGTCACCCGGCAACAATGACTCATGC
TTCTGTGGATGATAAAACGAAAAATCTACTAGGGATAGATGATGCCCTTGTCAGATTATCAATTGGATGTGAAGATGCAA
ACGATTTAATCTCGGATATTTTATTTGCTTTAAATAAATTTTGA

Upstream 100 bases:

>100_bases
GAATATTATTCAAGAAAAGTTTAATACAACTTTTCTTTGGATTATTAAATCTCTCGTTTAAAAAATGAGAGATTTAACTT
AATTCTTATTTTTAAAAATA

Downstream 100 bases:

>100_bases
AAATTGAGAGATTTACTTAAAAACCCTATATGGAAAAATTTAGAGTTAGGATATTCTATTCCTGATAGTATTCATGCCGT
TTCTGTAGCATTACCAACTT

Product: putative cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MGNKTNNIKKPGVKTLSIHHGETFAEDTGCIMPPIFSTSTFKHGNKESFDYTRSGNPNFKILENILKSIEDSKYCTVFGS
GISAVTAITSTLKSGDKILCESNLYGCTVRMFEKIFKKFGVEVLYTDFTNKNNIKKISNFAPTLIWLESPTNPLLKVLDI
KAICDEANKLQIPVVVDNTFSTALIQKPLELGATLSLVSTTKFINGHSDALGGAVLTNNEIWNSKMLFSQKALGLQPSPF
DSWLITRGVKTLPLRIEQQTRSAELISEELENHKIISKVIYPFNQKHPQFNLAKSQMISGGSMITLKLNLNKEDTFKLCK
SLKYFSLAESLGGVESLICHPATMTHASVDDKTKNLLGIDDALVRLSIGCEDANDLISDILFALNKF

Sequences:

>Translated_387_residues
MGNKTNNIKKPGVKTLSIHHGETFAEDTGCIMPPIFSTSTFKHGNKESFDYTRSGNPNFKILENILKSIEDSKYCTVFGS
GISAVTAITSTLKSGDKILCESNLYGCTVRMFEKIFKKFGVEVLYTDFTNKNNIKKISNFAPTLIWLESPTNPLLKVLDI
KAICDEANKLQIPVVVDNTFSTALIQKPLELGATLSLVSTTKFINGHSDALGGAVLTNNEIWNSKMLFSQKALGLQPSPF
DSWLITRGVKTLPLRIEQQTRSAELISEELENHKIISKVIYPFNQKHPQFNLAKSQMISGGSMITLKLNLNKEDTFKLCK
SLKYFSLAESLGGVESLICHPATMTHASVDDKTKNLLGIDDALVRLSIGCEDANDLISDILFALNKF
>Mature_386_residues
GNKTNNIKKPGVKTLSIHHGETFAEDTGCIMPPIFSTSTFKHGNKESFDYTRSGNPNFKILENILKSIEDSKYCTVFGSG
ISAVTAITSTLKSGDKILCESNLYGCTVRMFEKIFKKFGVEVLYTDFTNKNNIKKISNFAPTLIWLESPTNPLLKVLDIK
AICDEANKLQIPVVVDNTFSTALIQKPLELGATLSLVSTTKFINGHSDALGGAVLTNNEIWNSKMLFSQKALGLQPSPFD
SWLITRGVKTLPLRIEQQTRSAELISEELENHKIISKVIYPFNQKHPQFNLAKSQMISGGSMITLKLNLNKEDTFKLCKS
LKYFSLAESLGGVESLICHPATMTHASVDDKTKNLLGIDDALVRLSIGCEDANDLISDILFALNKF

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=360, Percent_Identity=40, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI299473759, Length=360, Percent_Identity=36.1111111111111, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI25453487, Length=359, Percent_Identity=35.6545961002786, Blast_Score=221, Evalue=7e-58,
Organism=Escherichia coli, GI1790375, Length=370, Percent_Identity=34.5945945945946, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789383, Length=348, Percent_Identity=28.1609195402299, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17538055, Length=368, Percent_Identity=41.0326086956522, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17560056, Length=368, Percent_Identity=41.0326086956522, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71980708, Length=378, Percent_Identity=32.8042328042328, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=38.4415584415584, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321254, Length=387, Percent_Identity=31.266149870801, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=29.156010230179, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323333, Length=425, Percent_Identity=29.6470588235294, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321170, Length=318, Percent_Identity=29.2452830188679, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19922554, Length=384, Percent_Identity=39.3229166666667, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42783; Mature: 42652

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNKTNNIKKPGVKTLSIHHGETFAEDTGCIMPPIFSTSTFKHGNKESFDYTRSGNPNFK
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ILENILKSIEDSKYCTVFGSGISAVTAITSTLKSGDKILCESNLYGCTVRMFEKIFKKFG
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCC
VEVLYTDFTNKNNIKKISNFAPTLIWLESPTNPLLKVLDIKAICDEANKLQIPVVVDNTF
CEEEEECCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCH
STALIQKPLELGATLSLVSTTKFINGHSDALGGAVLTNNEIWNSKMLFSQKALGLQPSPF
HHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCC
DSWLITRGVKTLPLRIEQQTRSAELISEELENHKIISKVIYPFNQKHPQFNLAKSQMISG
CHHHHHCCCEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
GSMITLKLNLNKEDTFKLCKSLKYFSLAESLGGVESLICHPATMTHASVDDKTKNLLGID
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCHHHHHCCCC
DALVRLSIGCEDANDLISDILFALNKF
CEEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNKTNNIKKPGVKTLSIHHGETFAEDTGCIMPPIFSTSTFKHGNKESFDYTRSGNPNFK
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ILENILKSIEDSKYCTVFGSGISAVTAITSTLKSGDKILCESNLYGCTVRMFEKIFKKFG
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCC
VEVLYTDFTNKNNIKKISNFAPTLIWLESPTNPLLKVLDIKAICDEANKLQIPVVVDNTF
CEEEEECCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCH
STALIQKPLELGATLSLVSTTKFINGHSDALGGAVLTNNEIWNSKMLFSQKALGLQPSPF
HHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCC
DSWLITRGVKTLPLRIEQQTRSAELISEELENHKIISKVIYPFNQKHPQFNLAKSQMISG
CHHHHHCCCEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
GSMITLKLNLNKEDTFKLCKSLKYFSLAESLGGVESLICHPATMTHASVDDKTKNLLGID
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCHHHHHCCCC
DALVRLSIGCEDANDLISDILFALNKF
CEEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]