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The map label for this gene is hisB

Identifier: 78778668

GI number: 78778668

Start: 271611

End: 272216

Strand: Reverse

Name: hisB

Synonym: PMT9312_0283

Alternate gene names: 78778668

Gene position: 272216-271611 (Counterclockwise)

Preceding gene: 78778669

Following gene: 78778667

Centisome position: 15.93

GC content: 33.99

Gene sequence:

>606_bases
ATGTCATCTCTAAGGCAATCTGAAATAAAAAGAAAAACGAATGAAACAGATATTTCTGTATTGATAAACTTAGATGGGAA
TGGGATTTCCGAGATTGAAACCGGGATACCATTCTTAGATCATATGCTTCATCAAATATCCAGTCATGGTTTATTCGATT
TAAAAATAAAAGCGATTGGAGATACCCATATTGATGATCATCATACAAATGAAGATGTAGGAATCGCGTTAGGCAAAGCA
TTTTCAAAAGCCTTGGGAGAACGAAAAGGAATAAGTAGATTTGGACATTTCTTTGCTCCATTAGATGAGGCATTAGTTCA
AGTGACTTTAGACTGTTCCGGCAGACCACATCTATCTTATGATCTTCAGTTAAAAGCTCCTAGAATTGGCAATTATGATA
CTGAACTAGTAAAAGAGTTTTTTATTGCCTTTGTAAATAACAGTGGTATTACTCTGCATATTAATCAAATAAGAGGTAGC
AATTCACATCATATAGTTGAGGCTTGCTTTAAAGCTTTTTCAAGAGCAATGAGAATGGCTACCGAAATAGATCTAAGAAG
ATCTGATTCAATTCCAAGCAGTAAAGGAATGCTAGAAAATCAATAA

Upstream 100 bases:

>100_bases
TTTTATTAAGTGATCTCTCTAGCGGCATTTCAGGCCAAACAATTTATGTTGATGCGGGTTACTGCATTAATGGAATGTAA
ACTAAATTTTTTGCATAAAA

Downstream 100 bases:

>100_bases
AATAGCAATTTTTTCGAATCAGCCACAATTCAGTTGATTTTTGGCGAAAATAAAAGGAGTAATTATTTTGTTGTGACTAA
TTTACAAGATAAAAAAATTG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSSLRQSEIKRKTNETDISVLINLDGNGISEIETGIPFLDHMLHQISSHGLFDLKIKAIGDTHIDDHHTNEDVGIALGKA
FSKALGERKGISRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGS
NSHHIVEACFKAFSRAMRMATEIDLRRSDSIPSSKGMLENQ

Sequences:

>Translated_201_residues
MSSLRQSEIKRKTNETDISVLINLDGNGISEIETGIPFLDHMLHQISSHGLFDLKIKAIGDTHIDDHHTNEDVGIALGKA
FSKALGERKGISRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGS
NSHHIVEACFKAFSRAMRMATEIDLRRSDSIPSSKGMLENQ
>Mature_200_residues
SSLRQSEIKRKTNETDISVLINLDGNGISEIETGIPFLDHMLHQISSHGLFDLKIKAIGDTHIDDHHTNEDVGIALGKAF
SKALGERKGISRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSN
SHHIVEACFKAFSRAMRMATEIDLRRSDSIPSSKGMLENQ

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=47.4226804123711, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22399; Mature: 22268

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLRQSEIKRKTNETDISVLINLDGNGISEIETGIPFLDHMLHQISSHGLFDLKIKAIG
CCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFSKALGERKGISRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEE
DLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSNSHHIVEACFKAFSRAMRMA
EEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSDSIPSSKGMLENQ
HHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSLRQSEIKRKTNETDISVLINLDGNGISEIETGIPFLDHMLHQISSHGLFDLKIKAIG
CCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFSKALGERKGISRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEE
DLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSNSHHIVEACFKAFSRAMRMA
EEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSDSIPSSKGMLENQ
HHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA