Click here to switch to the map view.

The map label for this gene is mutSB [H]

Identifier: 78778605

GI number: 78778605

Start: 211163

End: 213574

Strand: Direct

Name: mutSB [H]

Synonym: PMT9312_0219

Alternate gene names: 78778605

Gene position: 211163-213574 (Clockwise)

Preceding gene: 78778604

Following gene: 78778606

Centisome position: 12.35

GC content: 31.14

Gene sequence:

>2412_bases
ATGCAAGAGAAAAGTTTTTCTAAAAAATCATATTCAGAGAACACCTTAGAAGATGAATCTATAAGCCTTTTAGAGTGGGA
TTCAATAAAAACGCATTTATCCTCATTTGCCTCTACAGAAATGGGTAAACGAGCAATTTTAAGTTTTAAAATTCCTTCAG
AATACGAAGTTGCTAAAAGACTTTTGAATGAAACAGTTGAAATAACTGAGCTAGAAAATAATTTAGAAAAATCAATTAGT
TTTTCTGGTGTTTGTGACATTAGTAGAAATATTGAGATTTGCTCAAAAGGAGGTGTAATTTTATCTTCTGAATTGTTAGA
AATTGCAATAACAATTTCTGCGGCAAGAAATTTAAAAAAAATCTTATTAGATTTTGAAAAAAGGCCTTTTATTTCATCAT
TTACAAAAAATTTAATTGACCATCATAATATCGAAACGATTTTAAAAAATGGTATCGAATCTAATGGAAGGATTTCAGAT
GATGCTAGTAGTAAATTATCTATTCTCAGAAAAGAATTATTATCTAAGAAACTGGAAAGAAAAATATTAGTTGATAAATT
TATTCAAAAGAATCTAGCTTATTTGCAAGATACTATTATTGGAGATAGATATGGTAGACCTGTTTTAGCAGTAAAGGTTA
ATTATATTGATAAATTCAAGGGCATAATTCATGACTCTTCATCTTCAGGAAATACGGTATATTTTGAACCTGATAGCGTA
GTCACTAAAGGTAATAAGATCGCGTCTTTAGAGGCAAGGATCGCAGCAGAAGAATTTAAATTACTTCAGAAATGGTCTCA
AGTTATTAGTGATAATTCAGAAAATCTCATTGCAATGGCATCTATTTTATTAAGATTAGAAAATGCTTTAACCCGTTCAA
GATATTCGAAATGGATTGGAGGCAAAACTCCTATTTTTGAGGAAAATCCCATTATTTCCTTAATTGGTTTTTCTCATCCG
TTATTGATTTGGGAAAATAAGAAAAAAGGTTCCCCTCCCCCAGTGGCTGTTGATTTTCAAATAAATAGAAATATTAAGGT
TGTGGCTATTACAGGTCCAAATACTGGGGGGAAAACGGCAGCTTTAAAAGGTTTGGGTTTGTCGTTATTAATGGCTAGAG
CAGGATTATTGATACCTTCAACTAATAATCCAATTATCCCGTTTTGTCCAAATATATATGTTGATATAGGAGATAATCAA
TCATTAGAAGAAAATTTATCTACCTTCAGTGGGCATATATCCCGCATAAAAGAGATTTTAGAATCACTTGATAATAGGAG
AGGATTATCAGTTGTTTTGTTAGATGAAATTGGATCTGGTACAGATCCTCTTGAAGGTAGCGCTCTTGCGATGGCTTTGT
TAAAAGAATTTGCAAATAAATCTGATATCACTTTAGCAACTACACATTATGGAGATATTAAGGCATTAAAATATAATGAC
TCCAGATTCGAAAACGTTTCAGTTGCTTTTGATGAAGATTCTTTGAAGCCAAAATATATACTTAACTGGGGCATTCCTGG
GAGAAGTAATGCTTTGTCAATCTCGAAGAGAATTGGTCTCAATGAAAGCATACTAAATGAAGCTGCAAATTATCTAAAGC
CAAAAGAAGTTGATAATATTAACAGTATTATTAAAGGACTTGAGGAAGAGAGGATCAAGCAACAAAATTCTGCAGAAGCC
GCTGCAGAACTTATTGCTAGGACTGAAATATTACATGATGAACTGAAGAGAAATTATGAATATCAAAAAATAAATGCTGA
AAAAATTCAGGAAATTGAAAGGTATAAATTATCAAAAAAAATTATATCTGCTAAAAAAGAGGTAATAGATTTGATTAGAA
AATTAAGAGATCAAAATGTTAACGGAGAGGACACGAGAATTATTGGAAAAAGATTAAAAGAAATTGAGACAGAACATTTA
ACCCAAAAAAAAGTTGATAAGTCAATATCATGGAATCCCAAGGTAGGAGATTTTGTGAAAATTAAAAGTCTAAATAGTAC
TGGACAAATTGTAGATTTAGATAAAAAAGGTGGTTTTTACGAAGTTAAATGTGGTTCATTCAGGAGCATATTATCTGTAA
ATGACTTTGAAGGTATTAATGGGGAAAAGCCTAATTTCAAAAGATCAAAAATTGAGATCAAGTCTTCAAGAGAAGATTTT
TCTTTTTCTAAAGTTAGAACGAGTAAAAATACAATTGACGTAAGAGGACTAAGAGTTCACGAAGCCGAAATAATTATTGA
GGAGAAAATTAGAAAATTTCATGGACCGCTATGGATTGTTCATGGAATTGGAACAGGCAAATTAAAACAAGGTTTAAGAA
AATGGTTATCAGGTTTAAATTATGTTGATAAGATTGAAGATGCTGCACTCAACGAGGGTGGACCTGGTTGCAGTATTGCG
TGGATAAAATAA

Upstream 100 bases:

>100_bases
CAGCATCTTTTTATATGAAAGATACTGAAGGGAACTGGCTCGAGATGCTTTATGTTCCTCCTGAAGGGATTCAATCGAAT
GTTTGATTCTTTTTTTTTGT

Downstream 100 bases:

>100_bases
AATTTAAAATATTTAAAAACCATTGTTTAACTACATTAAGTGCAATTTATTGATCAAGCAAACATTATTCTTAAAGCTGG
AAAAGGTGGGAATGGAATAG

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 803; Mature: 803

Protein sequence:

>803_residues
MQEKSFSKKSYSENTLEDESISLLEWDSIKTHLSSFASTEMGKRAILSFKIPSEYEVAKRLLNETVEITELENNLEKSIS
FSGVCDISRNIEICSKGGVILSSELLEIAITISAARNLKKILLDFEKRPFISSFTKNLIDHHNIETILKNGIESNGRISD
DASSKLSILRKELLSKKLERKILVDKFIQKNLAYLQDTIIGDRYGRPVLAVKVNYIDKFKGIIHDSSSSGNTVYFEPDSV
VTKGNKIASLEARIAAEEFKLLQKWSQVISDNSENLIAMASILLRLENALTRSRYSKWIGGKTPIFEENPIISLIGFSHP
LLIWENKKKGSPPPVAVDFQINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKEILESLDNRRGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEDSLKPKYILNWGIPGRSNALSISKRIGLNESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEYQKINAEKIQEIERYKLSKKIISAKKEVIDLIRKLRDQNVNGEDTRIIGKRLKEIETEHL
TQKKVDKSISWNPKVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSILSVNDFEGINGEKPNFKRSKIEIKSSREDF
SFSKVRTSKNTIDVRGLRVHEAEIIIEEKIRKFHGPLWIVHGIGTGKLKQGLRKWLSGLNYVDKIEDAALNEGGPGCSIA
WIK

Sequences:

>Translated_803_residues
MQEKSFSKKSYSENTLEDESISLLEWDSIKTHLSSFASTEMGKRAILSFKIPSEYEVAKRLLNETVEITELENNLEKSIS
FSGVCDISRNIEICSKGGVILSSELLEIAITISAARNLKKILLDFEKRPFISSFTKNLIDHHNIETILKNGIESNGRISD
DASSKLSILRKELLSKKLERKILVDKFIQKNLAYLQDTIIGDRYGRPVLAVKVNYIDKFKGIIHDSSSSGNTVYFEPDSV
VTKGNKIASLEARIAAEEFKLLQKWSQVISDNSENLIAMASILLRLENALTRSRYSKWIGGKTPIFEENPIISLIGFSHP
LLIWENKKKGSPPPVAVDFQINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKEILESLDNRRGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEDSLKPKYILNWGIPGRSNALSISKRIGLNESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEYQKINAEKIQEIERYKLSKKIISAKKEVIDLIRKLRDQNVNGEDTRIIGKRLKEIETEHL
TQKKVDKSISWNPKVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSILSVNDFEGINGEKPNFKRSKIEIKSSREDF
SFSKVRTSKNTIDVRGLRVHEAEIIIEEKIRKFHGPLWIVHGIGTGKLKQGLRKWLSGLNYVDKIEDAALNEGGPGCSIA
WIK
>Mature_803_residues
MQEKSFSKKSYSENTLEDESISLLEWDSIKTHLSSFASTEMGKRAILSFKIPSEYEVAKRLLNETVEITELENNLEKSIS
FSGVCDISRNIEICSKGGVILSSELLEIAITISAARNLKKILLDFEKRPFISSFTKNLIDHHNIETILKNGIESNGRISD
DASSKLSILRKELLSKKLERKILVDKFIQKNLAYLQDTIIGDRYGRPVLAVKVNYIDKFKGIIHDSSSSGNTVYFEPDSV
VTKGNKIASLEARIAAEEFKLLQKWSQVISDNSENLIAMASILLRLENALTRSRYSKWIGGKTPIFEENPIISLIGFSHP
LLIWENKKKGSPPPVAVDFQINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKEILESLDNRRGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEDSLKPKYILNWGIPGRSNALSISKRIGLNESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEYQKINAEKIQEIERYKLSKKIISAKKEVIDLIRKLRDQNVNGEDTRIIGKRLKEIETEHL
TQKKVDKSISWNPKVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSILSVNDFEGINGEKPNFKRSKIEIKSSREDF
SFSKVRTSKNTIDVRGLRVHEAEIIIEEKIRKFHGPLWIVHGIGTGKLKQGLRKWLSGLNYVDKIEDAALNEGGPGCSIA
WIK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=213, Percent_Identity=30.5164319248826, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI4504191, Length=215, Percent_Identity=30.6976744186047, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI36949366, Length=210, Percent_Identity=29.0476190476191, Blast_Score=74, Evalue=8e-13,
Organism=Escherichia coli, GI1789089, Length=299, Percent_Identity=26.4214046822742, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=249, Percent_Identity=27.710843373494, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=217, Percent_Identity=24.4239631336406, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=193, Percent_Identity=32.1243523316062, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=269, Percent_Identity=26.7657992565056, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584320, Length=369, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664545, Length=189, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89961; Mature: 89961

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKSFSKKSYSENTLEDESISLLEWDSIKTHLSSFASTEMGKRAILSFKIPSEYEVAKR
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHH
LLNETVEITELENNLEKSISFSGVCDISRNIEICSKGGVILSSELLEIAITISAARNLKK
HHHCCEEHHHHHHHHHHHCCCCCEEECCCCCEEECCCCEEECCCHHHHEEHHHHHHHHHH
ILLDFEKRPFISSFTKNLIDHHNIETILKNGIESNGRISDDASSKLSILRKELLSKKLER
HHHHCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KILVDKFIQKNLAYLQDTIIGDRYGRPVLAVKVNYIDKFKGIIHDSSSSGNTVYFEPDSV
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHEECCCCCCCEEEECCCCE
VTKGNKIASLEARIAAEEFKLLQKWSQVISDNSENLIAMASILLRLENALTRSRYSKWIG
EECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GKTPIFEENPIISLIGFSHPLLIWENKKKGSPPPVAVDFQINRNIKVVAITGPNTGGKTA
CCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
ALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQSLEENLSTFSGHISRIKEIL
HHHHHHHHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ESLDNRRGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
HHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
SRFENVSVAFDEDSLKPKYILNWGIPGRSNALSISKRIGLNESILNEAANYLKPKEVDNI
CCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCHHHH
NSIIKGLEEERIKQQNSAEAAAELIARTEILHDELKRNYEYQKINAEKIQEIERYKLSKK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
IISAKKEVIDLIRKLRDQNVNGEDTRIIGKRLKEIETEHLTQKKVDKSISWNPKVGDFVK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
IKSLNSTGQIVDLDKKGGFYEVKCGSFRSILSVNDFEGINGEKPNFKRSKIEIKSSREDF
EEECCCCCCEEEEECCCCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
SFSKVRTSKNTIDVRGLRVHEAEIIIEEKIRKFHGPLWIVHGIGTGKLKQGLRKWLSGLN
CHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
YVDKIEDAALNEGGPGCSIAWIK
HHHHHHHHHCCCCCCCCEEEEEC
>Mature Secondary Structure
MQEKSFSKKSYSENTLEDESISLLEWDSIKTHLSSFASTEMGKRAILSFKIPSEYEVAKR
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHH
LLNETVEITELENNLEKSISFSGVCDISRNIEICSKGGVILSSELLEIAITISAARNLKK
HHHCCEEHHHHHHHHHHHCCCCCEEECCCCCEEECCCCEEECCCHHHHEEHHHHHHHHHH
ILLDFEKRPFISSFTKNLIDHHNIETILKNGIESNGRISDDASSKLSILRKELLSKKLER
HHHHCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KILVDKFIQKNLAYLQDTIIGDRYGRPVLAVKVNYIDKFKGIIHDSSSSGNTVYFEPDSV
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHEECCCCCCCEEEECCCCE
VTKGNKIASLEARIAAEEFKLLQKWSQVISDNSENLIAMASILLRLENALTRSRYSKWIG
EECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GKTPIFEENPIISLIGFSHPLLIWENKKKGSPPPVAVDFQINRNIKVVAITGPNTGGKTA
CCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
ALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQSLEENLSTFSGHISRIKEIL
HHHHHHHHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ESLDNRRGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
HHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
SRFENVSVAFDEDSLKPKYILNWGIPGRSNALSISKRIGLNESILNEAANYLKPKEVDNI
CCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCHHHH
NSIIKGLEEERIKQQNSAEAAAELIARTEILHDELKRNYEYQKINAEKIQEIERYKLSKK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
IISAKKEVIDLIRKLRDQNVNGEDTRIIGKRLKEIETEHLTQKKVDKSISWNPKVGDFVK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
IKSLNSTGQIVDLDKKGGFYEVKCGSFRSILSVNDFEGINGEKPNFKRSKIEIKSSREDF
EEECCCCCCEEEEECCCCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
SFSKVRTSKNTIDVRGLRVHEAEIIIEEKIRKFHGPLWIVHGIGTGKLKQGLRKWLSGLN
CHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
YVDKIEDAALNEGGPGCSIAWIK
HHHHHHHHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]