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The map label for this gene is gltA [H]

Identifier: 78778549

GI number: 78778549

Start: 156879

End: 158024

Strand: Reverse

Name: gltA [H]

Synonym: PMT9312_0163

Alternate gene names: 78778549

Gene position: 158024-156879 (Counterclockwise)

Preceding gene: 78778550

Following gene: 78778548

Centisome position: 9.25

GC content: 36.91

Gene sequence:

>1146_bases
TTGGATAGCAACAAACTAATTTTAAAACCCGGATTAGAGGGTGTCCCAGTTACTAATTCATCTATCTGTGATATTGACGG
CAACAAAGGTAAATTATTATATAGAGGCTACTCCATTGAGGAATTATCAAAAAAAAGCAGTTTTTTAGAAACTGCTTATC
TATTGATTTGGGGTGATTTACCTACAGCTATTCAACTAAGAGATTTTGAACAAGAAGTTCAAATGCATCGAAGGTTAAGT
TTTAGAGTCAGAGATATGATGAAATGTTTTCCTGCAACAGGTCATCCTATGGACGCGCTTCAGTCTAGTGCAGCTTCTTT
GGGTCTTTTCTATTCACGCAGAGCAATAGATGATCCTAATTACATCTACAACGCAGTGATAAGACTAATAGCAAAAATAC
CAACTATGATTGCTGCCTTTCAACTTATTAGAAAAGGACAAGACCCTATTCAACCTCGAGATGATTTAACTTACTCATCA
AATTTTCTTTACATGCTTACTGAAAAAGAACAAGATCCTATAGCTGCAAAAGTTTTTGATAGGTGTTTAATTCTACATGC
CGAACATAGTTTAAACGCAAGTACATTTAGCGCTAGAGTTACCGCAAGCACTCTTACAGACCCATATGCAGTCATTGCCT
CTGCAGTAGGAACCCTTGCTGGCCCGCTTCATGGAGGAGCAAATGAAGATGTGATTGCAATGTTAGAAGAAATCAAAACT
CCAAAAAATGCCGCCTCCTTTTTGGATAACGCGATAAAAAATAAAAGTAAGATAATGGGCTTCGGTCATAGAGAATACAA
AGTCAAAGATCCAAGAGCAATTATTCTTCAAAAACTTGCAGAAGAGCTTTTTATTAGATTTGGGGCAGATGAAATGTATG
AAGTTGCTAAATCACTAGAGGCAGAAGCAATACCAAGACTTGGACCAAAAGGTATATTCCCTAATGTAGATTTTTATTCC
GGTCTTGTTTATAGGAAACTTGGTATTCCTCGTGATTTATTTACTCCAATTTTTGCCATATCAAGGGTTGCTGGTTGGTT
AGCTCATTGGAGAGAGCAACTTGGAGCTAATAGAATCTTTAGACCATCGCAAATCTATACTGGTTCAGCTCCAAGGGAAT
GGATAAGCTTAGAAAATAGAGATTAA

Upstream 100 bases:

>100_bases
AAAAAATCAAAATAAATTTTTTTGAGGTTAATAACTTGTGGTTAATTAAAAATTATTTGACTATCTTTAATCTATAAGTA
TTTGATATTGAATTAGGAAA

Downstream 100 bases:

>100_bases
TATTTGCAGCTTTTCATAAAAAACACACATATTGTTGGTGACGAGTTAATGTATTAAGTAAATAACATTAAAATTTTGGA
ATACGGATTAGATCTTGAAT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSKKSSFLETAYLLIWGDLPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PKNAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPREWISLENRD

Sequences:

>Translated_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSKKSSFLETAYLLIWGDLPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PKNAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPREWISLENRD
>Mature_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSKKSSFLETAYLLIWGDLPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PKNAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPREWISLENRD

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=380, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI1786939, Length=383, Percent_Identity=38.9033942558747, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1786527, Length=385, Percent_Identity=34.025974025974, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17555174, Length=376, Percent_Identity=27.9255319148936, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=374, Percent_Identity=25.9358288770053, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=374, Percent_Identity=25.668449197861, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=370, Percent_Identity=22.972972972973, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356863, Length=389, Percent_Identity=26.2210796915167, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24640126, Length=395, Percent_Identity=27.0886075949367, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640124, Length=395, Percent_Identity=27.0886075949367, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42753; Mature: 42753

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSKKSSFLETAYLLIWGDL
CCCCCEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHEEEEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PKNAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CHHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPREWISLENRD
CCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSKKSSFLETAYLLIWGDL
CCCCCEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHEEEEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PKNAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CHHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPREWISLENRD
CCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]