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The map label for this gene is phoP [H]

Identifier: 78778516

GI number: 78778516

Start: 125872

End: 126654

Strand: Direct

Name: phoP [H]

Synonym: PMT9312_0130

Alternate gene names: 78778516

Gene position: 125872-126654 (Clockwise)

Preceding gene: 78778514

Following gene: 78778520

Centisome position: 7.36

GC content: 34.99

Gene sequence:

>783_bases
ATGAAAATTTCAATCCTTTTAATTGAAGATGATCGTGATATGCGTGATTTGGTAGCTAGGCATTTAGAACATTCTGGTTT
CGATGTCCAAAAAGCGGAAGATGGCATCAAAGGGCAGGCATTAGCTCTTCAATACTCGCCAGATTTAATTCTTTTAGATT
TAATGTTACCAAGTGTTGATGGATTAACTTTATGCCAGAGACTGAGAAGAGATGAAAGAACTTCAAATATCCCAATTTTG
ATGATAACTGCCTTAGGTGGACTAAAAGATAAAGTTACTGGTTTTAATTCTGGTGCCGATGACTACATTACTAAACCATT
TGATTTAGAAGAATTACATGTACGCATAAAAGCATTATTAAGAAGAACAAATAGAGCACAGTTGAACTCTAGTAATCAGC
AAGAAATTTTAAATTATGGACCTCTCACTCTTGTGCCGGAAAGATTTGAAGCTATCTGGTTTGAATCTCCTGTTAGATTA
ACTCATCTTGAATTTGAATTAATTCATTGTCTTTTACAAAGGCATGGTCAAACTGTATCACCAGCATTGATTCTCAAAGA
AGTATGGGGATATGAACCCGACGATGATATTGAGACAATCAGAGTTCATATTAGGCATTTACGTACTAAGCTAGAACCTG
ATCCACGTAAGCCTATATACATAAAAACTGTATATGGAGCTGGATATTGTCTTGAGTTACCTATTGGCTCTCAAGTTGAA
GCTGCCAAGCAAGATTTTATTCAAGCACGAAATCCTAATCTAATGAATTCTGTAATAGATTAA

Upstream 100 bases:

>100_bases
ATCTAATTGATAAAATTGTTTACACTAATTCAACAATCTTTCTAAATTCTTGAGAGAATCTTAATACTGAAACTTATTCT
TAATTTAATACTGTATAAGT

Downstream 100 bases:

>100_bases
ATTTCATATATCTTCCATTGAAATTTTTAAAAAGGTTATTTCCCATGCCAACCTTGGTTGAATATTTGTTCTTAAATAAA
ATTTTAAATTTTCAAGCTTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKISILLIEDDRDMRDLVARHLEHSGFDVQKAEDGIKGQALALQYSPDLILLDLMLPSVDGLTLCQRLRRDERTSNIPIL
MITALGGLKDKVTGFNSGADDYITKPFDLEELHVRIKALLRRTNRAQLNSSNQQEILNYGPLTLVPERFEAIWFESPVRL
THLEFELIHCLLQRHGQTVSPALILKEVWGYEPDDDIETIRVHIRHLRTKLEPDPRKPIYIKTVYGAGYCLELPIGSQVE
AAKQDFIQARNPNLMNSVID

Sequences:

>Translated_260_residues
MKISILLIEDDRDMRDLVARHLEHSGFDVQKAEDGIKGQALALQYSPDLILLDLMLPSVDGLTLCQRLRRDERTSNIPIL
MITALGGLKDKVTGFNSGADDYITKPFDLEELHVRIKALLRRTNRAQLNSSNQQEILNYGPLTLVPERFEAIWFESPVRL
THLEFELIHCLLQRHGQTVSPALILKEVWGYEPDDDIETIRVHIRHLRTKLEPDPRKPIYIKTVYGAGYCLELPIGSQVE
AAKQDFIQARNPNLMNSVID
>Mature_260_residues
MKISILLIEDDRDMRDLVARHLEHSGFDVQKAEDGIKGQALALQYSPDLILLDLMLPSVDGLTLCQRLRRDERTSNIPIL
MITALGGLKDKVTGFNSGADDYITKPFDLEELHVRIKALLRRTNRAQLNSSNQQEILNYGPLTLVPERFEAIWFESPVRL
THLEFELIHCLLQRHGQTVSPALILKEVWGYEPDDDIETIRVHIRHLRTKLEPDPRKPIYIKTVYGAGYCLELPIGSQVE
AAKQDFIQARNPNLMNSVID

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=37.117903930131, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=35.4700854700855, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=36.0169491525424, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=35.3711790393013, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=36.0869565217391, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=36.6812227074236, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=32.1739130434783, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=36.6812227074236, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787375, Length=234, Percent_Identity=31.1965811965812, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=31.5789473684211, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=35.3448275862069, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.4410480349345, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=30.6034482758621, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=29.0598290598291, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=107, Percent_Identity=29.9065420560748, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29699; Mature: 29699

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISILLIEDDRDMRDLVARHLEHSGFDVQKAEDGIKGQALALQYSPDLILLDLMLPSVD
CEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCCEEEEEEHHCCCC
GLTLCQRLRRDERTSNIPILMITALGGLKDKVTGFNSGADDYITKPFDLEELHVRIKALL
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RRTNRAQLNSSNQQEILNYGPLTLVPERFEAIWFESPVRLTHLEFELIHCLLQRHGQTVS
HHHHHHHCCCCCHHHHHHCCCEEECHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCC
PALILKEVWGYEPDDDIETIRVHIRHLRTKLEPDPRKPIYIKTVYGAGYCLELPIGSQVE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCCHH
AAKQDFIQARNPNLMNSVID
HHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MKISILLIEDDRDMRDLVARHLEHSGFDVQKAEDGIKGQALALQYSPDLILLDLMLPSVD
CEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCCEEEEEEHHCCCC
GLTLCQRLRRDERTSNIPILMITALGGLKDKVTGFNSGADDYITKPFDLEELHVRIKALL
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RRTNRAQLNSSNQQEILNYGPLTLVPERFEAIWFESPVRLTHLEFELIHCLLQRHGQTVS
HHHHHHHCCCCCHHHHHHCCCEEECHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCC
PALILKEVWGYEPDDDIETIRVHIRHLRTKLEPDPRKPIYIKTVYGAGYCLELPIGSQVE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCCHH
AAKQDFIQARNPNLMNSVID
HHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]