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The map label for this gene is era

Identifier: 78358630

GI number: 78358630

Start: 3548044

End: 3548970

Strand: Reverse

Name: era

Synonym: Dde_3591

Alternate gene names: 78358630

Gene position: 3548970-3548044 (Counterclockwise)

Preceding gene: 78358633

Following gene: 78358629

Centisome position: 95.14

GC content: 58.04

Gene sequence:

>927_bases
ATGACGCATTCTTCAGAACACCGTTGCGGCTGGGTAGCGCTGATGGGCCCGCCCAACGCGGGCAAATCCACAATGATGAA
CAGCCTGCTGGGGCAGAAGGTAGCCATTGTGACGCCCAAACCGCAGACCACCCGTAACCAGATTGTGGGCATTCTTACAC
AGCCCGACGCTCAGGTGGTTTTCATGGATACGCCGGGTATCCACCAGCTGCGCGGCAAGATGAACCGGCTGCTGCTGCAG
GCCGCATGGCAGAGCATGGACGGCGCCGATGTGATTATGGTGGTGCTGGACAGCAATCTGTACGTCCGCAAGCCGGATTT
TCTGGATAACGACATTGAGCCGCTTATCGAGGTCATCCGGCACGAAAAACGTCCGGTGGTTGTGGCGCTGAACAAGGTCG
ACATGTTTGCCGACAAGTCGCGCATGCTGCCGCTGCTGGAAAAGCTGGCCGAAATGTGGCCCGCTGCCGAGATTTTTCCC
GTTTCAGCATTGAATGACGACGGCCTGCGCCAGATGCTTGCCTTTATCAAGGGGCACCTGCCCGTGGCCGACCCCGTGTT
TCCCGACGATCAGGTTTCCACTGCGCCGCTGCGGTTCATGGCTGCGGAAATCATCCGCGAGAAGCTGTTTCTGGAACTGC
GTCAGGAGCTGCCCTACAACAGCGCCGTAAGCGTGGAAAAGTGGGAAGATCTGGAAGAGGAAGGCCGTGTGGTCATTCAC
GCCGTGATTCACGTTGCCCGCAAGAACCACAAAGGCATGGTCATCGGCAGGCAGGGGCAGACGCTGAAAAAAATAGGCAC
CGATGCGCGTAAGGAAATCGAGGCGCTGGTTGACCGCAAGGTGTTTCTTGACCTGTGGGTGCGCGTCACCGACGACTGGA
TGGACAACGAACAGTTTATGGTTGAAATCGGCATGGGGGCCCGCTAG

Upstream 100 bases:

>100_bases
TGTCCGGTAACATACCGTGGCGCGCTGCTTGACTTTGCGGTAAGGGGATGAAAGAAGGTTCGGTTTATTTACGACCACTA
CATCAGGAGATGATTTTTAT

Downstream 100 bases:

>100_bases
CCCCGCCGGTTACGGCCTGCTGCCGGTATTGTCTGCGCCGCGATGCCCTGCCTGACGGCGGGGCATTGCTGTTTGGGGCG
GTGGCGGCTGTCAAAAAAAC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTHSSEHRCGWVALMGPPNAGKSTMMNSLLGQKVAIVTPKPQTTRNQIVGILTQPDAQVVFMDTPGIHQLRGKMNRLLLQ
AAWQSMDGADVIMVVLDSNLYVRKPDFLDNDIEPLIEVIRHEKRPVVVALNKVDMFADKSRMLPLLEKLAEMWPAAEIFP
VSALNDDGLRQMLAFIKGHLPVADPVFPDDQVSTAPLRFMAAEIIREKLFLELRQELPYNSAVSVEKWEDLEEEGRVVIH
AVIHVARKNHKGMVIGRQGQTLKKIGTDARKEIEALVDRKVFLDLWVRVTDDWMDNEQFMVEIGMGAR

Sequences:

>Translated_308_residues
MTHSSEHRCGWVALMGPPNAGKSTMMNSLLGQKVAIVTPKPQTTRNQIVGILTQPDAQVVFMDTPGIHQLRGKMNRLLLQ
AAWQSMDGADVIMVVLDSNLYVRKPDFLDNDIEPLIEVIRHEKRPVVVALNKVDMFADKSRMLPLLEKLAEMWPAAEIFP
VSALNDDGLRQMLAFIKGHLPVADPVFPDDQVSTAPLRFMAAEIIREKLFLELRQELPYNSAVSVEKWEDLEEEGRVVIH
AVIHVARKNHKGMVIGRQGQTLKKIGTDARKEIEALVDRKVFLDLWVRVTDDWMDNEQFMVEIGMGAR
>Mature_307_residues
THSSEHRCGWVALMGPPNAGKSTMMNSLLGQKVAIVTPKPQTTRNQIVGILTQPDAQVVFMDTPGIHQLRGKMNRLLLQA
AWQSMDGADVIMVVLDSNLYVRKPDFLDNDIEPLIEVIRHEKRPVVVALNKVDMFADKSRMLPLLEKLAEMWPAAEIFPV
SALNDDGLRQMLAFIKGHLPVADPVFPDDQVSTAPLRFMAAEIIREKLFLELRQELPYNSAVSVEKWEDLEEEGRVVIHA
VIHVARKNHKGMVIGRQGQTLKKIGTDARKEIEALVDRKVFLDLWVRVTDDWMDNEQFMVEIGMGAR

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=307, Percent_Identity=29.3159609120521, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1788919, Length=297, Percent_Identity=38.7205387205387, Blast_Score=213, Evalue=9e-57,
Organism=Escherichia coli, GI87082120, Length=172, Percent_Identity=26.7441860465116, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17507259, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646434, Length=260, Percent_Identity=28.0769230769231, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34817; Mature: 34686

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSSEHRCGWVALMGPPNAGKSTMMNSLLGQKVAIVTPKPQTTRNQIVGILTQPDAQVV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEE
FMDTPGIHQLRGKMNRLLLQAAWQSMDGADVIMVVLDSNLYVRKPDFLDNDIEPLIEVIR
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHH
HEKRPVVVALNKVDMFADKSRMLPLLEKLAEMWPAAEIFPVSALNDDGLRQMLAFIKGHL
CCCCCEEEEEECHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC
PVADPVFPDDQVSTAPLRFMAAEIIREKLFLELRQELPYNSAVSVEKWEDLEEEGRVVIH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHCCCEEHH
AVIHVARKNHKGMVIGRQGQTLKKIGTDARKEIEALVDRKVFLDLWVRVTDDWMDNEQFM
HHHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VEIGMGAR
EEECCCCC
>Mature Secondary Structure 
THSSEHRCGWVALMGPPNAGKSTMMNSLLGQKVAIVTPKPQTTRNQIVGILTQPDAQVV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEE
FMDTPGIHQLRGKMNRLLLQAAWQSMDGADVIMVVLDSNLYVRKPDFLDNDIEPLIEVIR
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHH
HEKRPVVVALNKVDMFADKSRMLPLLEKLAEMWPAAEIFPVSALNDDGLRQMLAFIKGHL
CCCCCEEEEEECHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC
PVADPVFPDDQVSTAPLRFMAAEIIREKLFLELRQELPYNSAVSVEKWEDLEEEGRVVIH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHCCCEEHH
AVIHVARKNHKGMVIGRQGQTLKKIGTDARKEIEALVDRKVFLDLWVRVTDDWMDNEQFM
HHHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VEIGMGAR
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA